Shenyi Jiang
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View article: [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis].
[Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis]. Open
In rats with LPS-induced sepsis, activation of CB2 can inhibit the p38 MAPK signaling pathway, reduce the release of inflammatory factors in the lung tissues, promote tight junction protein expressions, and thus offer protection against ac…
View article: Cortical Hyperexcitability in the Driver’s Seat in ALS
Cortical Hyperexcitability in the Driver’s Seat in ALS Open
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by the degeneration of cortical and spinal motor neurons. With no effective treatment available to date, patients face progressive paralysis and eventually succumb to the…
View article: Correction to: GPC3 affects the prognosis of lung adenocarcinoma and lung squamous cell carcinoma
Correction to: GPC3 affects the prognosis of lung adenocarcinoma and lung squamous cell carcinoma Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Expression of cleaved caspase-3 predicts good chemotherapy response but poor survival for patients with advanced primary triple-negative breast cancer.
Expression of cleaved caspase-3 predicts good chemotherapy response but poor survival for patients with advanced primary triple-negative breast cancer. Open
Our CC3-positive group exhibited a better chemotherapy response, but a worse prognosis. The Ki-67 high-risk and E-cad negative groups exhibited both a worse chemotherapy response and worse prognosis.
View article: The association between the <i>TP53</i> Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies
The association between the <i>TP53</i> Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies Open
Several previous studies evaluated the association between the Arg72Pro (rs1042522) polymorphism in the TP53 tumor suppressor gene and colorectal cancer (CRC). However, the results are conflicting. This meta-analysis aimed to shed new ligh…
View article: Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis
Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis Open
Nemo-like kinase (NLK), an evolutionarily conserved serine/threonine kinase, has been recognized as a critical regulator of various cancers. In this study, we investigated the role of NLK in human small-cell lung cancer (SCLC), which is th…
View article: IL-35 Inhibits Angiogenesis through VEGF/Ang2/Tie2 Pathway in Rheumatoid Arthritis
IL-35 Inhibits Angiogenesis through VEGF/Ang2/Tie2 Pathway in Rheumatoid Arthritis Open
Background/Aims: The pro-angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietins (Angs) play a prominent role in synovial angiogenesis, an early and critical event in the pathogenesis of rheumatoid arthritis (RA). In…
View article: Inhibition of MDM2 Re-Sensitizes Rapamycin Resistant Renal Cancer Cells via the Activation of p53
Inhibition of MDM2 Re-Sensitizes Rapamycin Resistant Renal Cancer Cells via the Activation of p53 Open
Background/Aims: Rapamycin is a potential anti-cancer agent, which modulates the activity of mTOR, a key regulator of cell growth and proliferation. However, several types of cancer cells are resistant to the anti-proliferative effects of …
View article: Transarterial chemoembolization versus hepatic resection in hepatocellular carcinoma treatment: a&nbsp;meta-analysis
Transarterial chemoembolization versus hepatic resection in hepatocellular carcinoma treatment: a meta-analysis Open
This meta-analysis suggests that the TACE and HR likely have similar effects in the treatment of HCC patients in terms of OS and recurrence rate. However, this conclusion should be interpreted cautiously due to the presence of further subg…
View article: F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression
F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression Open
Kruppel-like factor 4 (KLF4), a member of the KLF family of transcription factors, has been considered as a crucial tumor suppressor in hepatocellular carcinoma (HCC). Using affinity purifications and mass spectrometry, we identified FBXO2…
View article: Bufalin Induces Mitochondria-Dependent Apoptosis in Pancreatic and Oral Cancer Cells by Downregulating hTERT Expression via Activation of the JNK/p38 Pathway
Bufalin Induces Mitochondria-Dependent Apoptosis in Pancreatic and Oral Cancer Cells by Downregulating hTERT Expression via Activation of the JNK/p38 Pathway Open
Bufalin, a digoxin-like active component of the traditional Chinese medicine Chan Su, exhibits potent antitumor activities in many human cancers. Bufalin induces mitochondria-dependent apoptosis in cancer cells, but the detailed molecular …