Explanipedia

DeepFundus: A flow-cytometry-like image quality classifier for boosting the whole life cycle of medical artificial intelligence Open

Lixue Liu, Xiaohang Wu, Duoru Lin, Lanqin Zhao, Mingyuan Li , et al. · 2023

Medical artificial intelligence (AI) has been moving from the research phase to clinical implementation. However, most AI-based models are mainly built using high-quality images preprocessed in the laboratory, which is not representative o…

Altered expression profile of long non-coding RNAs during heart aging in mice Open

Xiuxiu Wang, Bingjie Hua, Meixi Yu, Shenzhen Liu, Wenya Ma , et al. · 2022

Objective Long noncoding RNAs (lncRNAs) play an important role in regulating the occurrence and development of cardiovascular diseases. However, the role of lncRNAs in heart aging remains poorly understood. The objective of this study was …

Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR Open

Mingyu He, Gege Yan, Yang Wang, Rui Gong, Lei Hong , et al. · 2021

Osteosarcoma (OS) is the most common primary malignant bone tumour in adolescence. Lately, light‐emitting diodes (LED)‐based therapy has emerged as a new promising approach for several diseases. However, it remains unknown in human OS. Her…

ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1 Open

Zhenbo Han, Xiuxiu Wang, Zihang Xu, Yang Cao, Rui Gong , et al. · 2021

N⁶-methyladenosine (m⁶A) RNA modification, a dynamic and reversible process, is essential for tissue development and pathogenesis. However, the potential involvement of m⁶A in the regulation of cardiomyocyt…

Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway Open

Wenya Ma, Ruijie Song, Binbin Xu, Yan Xu, Xiuxiu Wang , et al. · 2020

Iron overload inhibits self‐renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species Open

Zhenbo Han, Zihang Xu, Lei Chen, Danyu Ye, Yu Yang , et al. · 2020

Iron overload affects the cell cycle of various cell types, but the effect of iron overload on human pluripotent stem cells has not yet been reported. Here, we show that the proliferation capacities of human embryonic stem cells (hESCs) an…

Targeting LncDACH1 promotes cardiac repair and regeneration after myocardium infarction Open

Benzhi Cai, Wenya Ma, Xiuxiu Wang, Natalia Sukhareva, Bingjie Hua , et al. · 2020

m6A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells Open

Gege Yan, Ye Yuan, Mingyu He, Rui Gong, Lei Hong , et al. · 2019

Methyltransferase-like 3 (METTL3) is the main enzyme for N⁶-methyladenosine (m⁶A)-based methylation of RNAs and it has been implicated in many biological and pathophysiological processes. In this study, we aimed to ex…

miR-149-3p Regulates the Switch between Adipogenic and Osteogenic Differentiation of BMSCs by Targeting FTO Open

Yuan Li, Fan Yang, Manqi Gao, Rui Gong, Mengyu Jin , et al. · 2019

Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell differentiation program is crucial to the bone microenvironment …

MiR-149-3p Regulates the Switch Between Adipogenic and Osteogenic Differentiation of BMSCs by Targeting FTO Open

Yuan Li, Rui Gong, Manqi Gao, Mengyu Jin, Tianyi Liu , et al. · 2019

Synergistic anti-tumor effects of arsenic trioxide and blue LED irradiation on human osteosarcoma Open

Chao Feng, Rui Gong, Qiuyan Zheng, Gege Yan, Mingyu He , et al. · 2019

Arsenic trioxide (ATO) has been well recognized as an anti-tumor agent for various human cancers. Recently, the blue light emitting diodes (LEDs)-based therapy has also been demonstrated to be potential therapeutic strategies for several c…

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