Sheree Johnstone
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View article: Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies
Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies Open
Biologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient ad…
View article: Structure-guided discovery of dual recognition chemibodies
Structure-guided discovery of dual recognition chemibodies Open
Small molecules and antibodies each have advantages and limitations as therapeutics. Here, we present for the first time to our knowledge, the structure-guided design of as small molecule-antibody hybrids that offer dual recognition of a …
View article: Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions Open
View article: Structure-guided Discovery of Dual-recognition Chemibodies
Structure-guided Discovery of Dual-recognition Chemibodies Open
View article: Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4
Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4 Open