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View article: Effect of Supine versus Right Lateral Position on Intra-Abdominal Pressure Measurements and Respiratory Dynamics for Critically Ill Patients
Effect of Supine versus Right Lateral Position on Intra-Abdominal Pressure Measurements and Respiratory Dynamics for Critically Ill Patients Open
View article: Sofosbuvir’s hepatoprotective efficacy in rats is enhanced by encapsulating in taurocholate-stabilized galactose-anchored bilosomes
Sofosbuvir’s hepatoprotective efficacy in rats is enhanced by encapsulating in taurocholate-stabilized galactose-anchored bilosomes Open
Background In conjunction with other antiviral medicines, sofosbuvir (SOF) is an essential therapy for chronic hepatitis C. There is some debate over its influence on hepatic fibrosis. The use of nanotechnology in treatment has gained popu…
View article: The use of PRAME immunohistochemistry in diagnosing the spectrum of primary undifferentiated and dedifferentiated melanomas: a case series
The use of PRAME immunohistochemistry in diagnosing the spectrum of primary undifferentiated and dedifferentiated melanomas: a case series Open
View article: Case report: a rare presentation of basal cell adenocarcinoma-like low grade spiradenocylindroma
Case report: a rare presentation of basal cell adenocarcinoma-like low grade spiradenocylindroma Open
View article: Use and outcomes of antihypertensive medication treatment in the US hypertensive population: A gender comparison
Use and outcomes of antihypertensive medication treatment in the US hypertensive population: A gender comparison Open
Background: Although effective antihypertensive medications have existed for decades, only about half of the hypertensive individuals are considered to have controlled blood pressure. Limited research studies have investigated gender dispa…
View article: More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients
More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients Open
In parallel with the decline of renal excretory function, drug dosing of many drugs becomes more challenging. Finding the right dose is even more difficult if kidney replacement therapy is instituted. This is further aggravated by the fact…
View article: Speech-Language Pathology Management for Adults with COVID-19 in the Acute Hospital Setting: What Do We Know?
Speech-Language Pathology Management for Adults with COVID-19 in the Acute Hospital Setting: What Do We Know? Open
The purpose of this study was to collate and summarize the content covered in published literature describing speech-language pathology management of adult patients with COVID-19 in the acute hospital setting as of February 2022. This revi…
View article: Virtual Behavioral Health Treatment Satisfaction and Outcomes Across Time
Virtual Behavioral Health Treatment Satisfaction and Outcomes Across Time Open
If trends found in this study continue, telehealth may emerge as a preferred option long term This is important considering the increase in mental health needs associated with the COVID-19 pandemic and the eventuality that in-person restri…
View article: Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model
Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model Open
View article: IgG4-related liver disease, presenting as a liver tumour (a case report and review of literature)
IgG4-related liver disease, presenting as a liver tumour (a case report and review of literature) Open
View article: Donor Heart Preservation by Hypothermic Ex Vivo Perfusion - Improved Recipient Survival and Successful Prolongation of Ischemic Time
Donor Heart Preservation by Hypothermic Ex Vivo Perfusion - Improved Recipient Survival and Successful Prolongation of Ischemic Time Open
View article: Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system
Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system Open
View article: Metabolic and Mitochondrial Alterations Following Brain Death and Heart Transplantation
Metabolic and Mitochondrial Alterations Following Brain Death and Heart Transplantation Open
View article: 120 Hypothermic Ex Vivo Perfusion of Brain Dead Donor Hearts Improves Survival, Systemic Inflammation and Cardiac Function Following Heart Transplantation
120 Hypothermic Ex Vivo Perfusion of Brain Dead Donor Hearts Improves Survival, Systemic Inflammation and Cardiac Function Following Heart Transplantation Open
View article: 121 Hypothermic Ex Vivo Perfusion Preserves Post-Transplant Donor Cardiac Function
121 Hypothermic Ex Vivo Perfusion Preserves Post-Transplant Donor Cardiac Function Open
View article: Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model
Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model Open
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Nebulized antibiotics may be used to treat ventilator-associated pneumonia. In previous pharmacokinetic studies, lung interstitial…
View article: The effects of normovolemic anemia and blood transfusion on cerebral microcirculation after severe head injury
The effects of normovolemic anemia and blood transfusion on cerebral microcirculation after severe head injury Open
After severe head injury, the exposure to normovolemic anemia to a restrictive transfusion threshold, leads to a consistent reduction on cerebral microcirculation below ischemic thresholds, independent of cerebral perfusion pressure. Among…
View article: In Vitro Hemocompatibility Evaluation of Ventricular Assist Devices in Pediatric Flow Conditions: A Benchmark Study
In Vitro Hemocompatibility Evaluation of Ventricular Assist Devices in Pediatric Flow Conditions: A Benchmark Study Open
Development of pediatric ventricular assist devices (VADs) has significantly lagged behind that of adult devices. This frustrating reality is reflected by the fact that the Berlin Heart EXCOR VAD is currently the only approved pediatric‐sp…
View article: A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models
A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models Open
View article: Unintended Consequences: Fluid Resuscitation Worsens Shock in an Ovine Model of Endotoxemia
Unintended Consequences: Fluid Resuscitation Worsens Shock in an Ovine Model of Endotoxemia Open
Fluid resuscitation resulted in a paradoxical increase in vasopressor requirement. Additionally, it did not result in improvements in any of the measured microcirculatory- or organ-specific markers measured. The increase in vasopressor req…
View article: Cerebral Microcirculation and Histological Mapping After Severe Head Injury: A Contusion and Acceleration Experimental Model
Cerebral Microcirculation and Histological Mapping After Severe Head Injury: A Contusion and Acceleration Experimental Model Open
Microcirculation at the ipsilateral and contralateral site of a contusion and the ipsilateral thalamus and medulla showed a consistent decline over time. Our data suggest that after severe head injury, microcirculation in predefined areas …
View article: Packed red cell age associated with adverse cardiovascular changes in an ovine model of septic shock resuscitation
Packed red cell age associated with adverse cardiovascular changes in an ovine model of septic shock resuscitation Open
Introduction: Packed red blood cell (PRBC) transfusion in septic shock is generally reserved as a last resort hemodynamic resuscitative measure or for haemoglobin less than 7.0 g/dL. Ex-vivo preservation and storage predispose PRBCs to bio…
View article: An Ovine Model of Hyperdynamic Endotoxemia and Vital Organ Metabolism
An Ovine Model of Hyperdynamic Endotoxemia and Vital Organ Metabolism Open
Background: Animal models of endotoxemia are frequently used to understand the pathophysiology of sepsis and test new therapies. However, important differences exist between commonly used experimental models of endotoxemia and clinical sep…
View article: Expression of ERG Protein and TMRPSS2-ERG Fusion in Prostatic Carcinoma in Egyptian Patients
Expression of ERG Protein and TMRPSS2-ERG Fusion in Prostatic Carcinoma in Egyptian Patients Open
AIM: Prostate cancer (PCa) is the second most common cancers in men worldwide. Its incidence can be influenced by several risk factors including genetic susceptibility. Therefore the search for the expression of a certain gene (ERG) and it…
View article: A Histologic Approach to Qualify Lung Tissue Damage in a Sheep Model of Transfusion-Related Lung Injury: Role of Red Blood Cell Storage Duration and Heat Treatment
A Histologic Approach to Qualify Lung Tissue Damage in a Sheep Model of Transfusion-Related Lung Injury: Role of Red Blood Cell Storage Duration and Heat Treatment Open
View article: Activation of the protein C pathway and endothelial glycocalyx shedding is associated with coagulopathy in an ovine model of trauma and hemorrhage
Activation of the protein C pathway and endothelial glycocalyx shedding is associated with coagulopathy in an ovine model of trauma and hemorrhage Open
Animals in the severe trauma group developed coagulation changes consistent with current definitions of ATC. The degree of coagulopathy was correlated with the degree of shock, quantified by arterial lactate. Activation of the protein C pa…
View article: Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit
Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit Open
View article: Cerebral Microcirculation during Experimental Normovolaemic Anemia
Cerebral Microcirculation during Experimental Normovolaemic Anemia Open
Anemia is accepted among critically ill patients as an alternative to elective blood transfusion. This practice has been extrapolated to head injury patients with only one study comparing the effects of mild anemia on neurological outcome.…
View article: In Vivo Evaluation of Active and Passive Physiological Control Systems for Rotary Left and Right Ventricular Assist Devices
In Vivo Evaluation of Active and Passive Physiological Control Systems for Rotary Left and Right Ventricular Assist Devices Open
Preventing ventricular suction and venous congestion through balancing flow rates and circulatory volumes with dual rotary ventricular assist devices ( VADs ) configured for biventricular support is clinically challenging due to their low …
View article: Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models
Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models Open