Sunil Thomas
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View article: Charting the Proteins of Oropouche Virus
Charting the Proteins of Oropouche Virus Open
Oropouche virus (OROV) is an emerging arbovirus responsible for Oropouche fever, also known as sloth fever, a febrile illness that can lead to recurrent outbreaks in affected regions. Endemic to parts of South and Central America, OROV is …
View article: The structure of the proteins of Camp Hill virus
The structure of the proteins of Camp Hill virus Open
Camp Hill virus (CHV), a newly identified henipavirus, was recently discovered in northern short-tailed shrews in Camp Hill, Alabama. This marks a significant event as it is the first henipavirus ever reported in North America. The signifi…
View article: Molecular Mechanisms Driving Peinosis of the Colon in Obesity
Molecular Mechanisms Driving Peinosis of the Colon in Obesity Open
Obesity, driven largely by the overconsumption of foods high in fats and sugars, is now more prevalent than at any other time in human history and is a major risk factor for numerous chronic diseases that impair quality of life and shorten…
View article: The Structure of the Proteins of Camp Hill Virus
The Structure of the Proteins of Camp Hill Virus Open
Camp Hill virus (CHV), a newly identified henipavirus, was recently discovered in northern short-tailed shrews in Camp Hill, Alabama. This marks a significant event as it is the first henipavirus ever reported in North America. The signifi…
View article: Goal-specific hippocampal inhibition gates learning
Goal-specific hippocampal inhibition gates learning Open
Goal-directed navigation in a new environment requires quickly identifying and exploiting important locations. Identifying new goal locations depends on neural computations that rapidly represent locations and connect location information …
View article: Dandelion (Taraxacum officinale) has successfully adapted to grow in suburban environments
Dandelion (Taraxacum officinale) has successfully adapted to grow in suburban environments Open
View article: Utilizing the biosimulator to analyze the environmental microbiome within the intensive care units of a hospital
Utilizing the biosimulator to analyze the environmental microbiome within the intensive care units of a hospital Open
Hospital-acquired infections (HAIs), also known as nosocomial infections, are illnesses contracted during treatment at a healthcare facility and can result in severe or life-threatening complications. HAIs are caused by microorganisms that…
View article: Plotting the major proteins of borealpox virus
Plotting the major proteins of borealpox virus Open
In an era marked by rapid environmental transformations, the viability of numerous species hinges crucially on their ability to navigate and adjust to shifting climatic conditions through migration. Yet, amidst this natural quest for survi…
View article: Charting the Proteins of Oropouche Virus
Charting the Proteins of Oropouche Virus Open
The Oropouche virus (OROV) is responsible for the disease Oropouche fever, also known as sloth fever. This virus is currently endemic to the Americas and is transmitted primarily through midges and mosquitoes. Recently, an increase in case…
View article: Utilizing the biosimulator to analyze the environmental microbiome within the intensive care units of a hospital
Utilizing the biosimulator to analyze the environmental microbiome within the intensive care units of a hospital Open
In our previous study, we demonstrated the ability of an engraved Petri dish, referred to as a "biosimulator," to induce adhesion of non-adherent cells and the microbiome. This paper delves into the utilization of this innovative biosimula…
View article: Dandelion (Taraxacum officinale) has successfully adapted to Grow in Suburban Environments
Dandelion (Taraxacum officinale) has successfully adapted to Grow in Suburban Environments Open
Dandelion ( Taraxacum officinale (L.) Weber ex F.H. Wigg) is a perennial herbaceous plant that, although not native to its current habitats, has become invasive, posing economic challenges by outcompeting indigenous flora and agricultural …
View article: Dandelion (Taraxacum officinale) has Successfully Adapted to Grow in Suburban Environments
Dandelion (Taraxacum officinale) has Successfully Adapted to Grow in Suburban Environments Open
Dandelion ( Taraxacum officinale (L.) Weber ex F.H. Wigg) is a perennial herbaceous plant that, although not native to its current habitats, has become invasive, posing economic challenges by outcompeting indigenous flora and agricultural …
View article: Plotting the Major Proteins of Borealpox Virus
Plotting the Major Proteins of Borealpox Virus Open
In an era marked by rapid environmental transformations, the viability of numerous species hinges crucially on their ability to navigate and adjust to shifting climatic conditions through migration. Yet, amidst this natural quest for survi…
View article: Plotting the Major Proteins of Alaskapox Virus
Plotting the Major Proteins of Alaskapox Virus Open
In an era marked by rapid environmental transformations, the viability of numerous species hinges crucially on their ability to navigate and adjust to shifting climatic conditions through migration. Yet, amidst this natural quest for survi…
View article: Dandelion Has Successfully Adapted to Grow in Suburban Environments
Dandelion Has Successfully Adapted to Grow in Suburban Environments Open
Dandelion ( Taraxacum officinale G.H. Weber ex Wiggers) is a perennial herbaceous plant, generally considered as a weed, often seen blooming in the temperate areas during early spring. The wind dispersed seeds of dandelion has been known t…
View article: Diet effects on colonic health influence the efficacy of Bin1 mAb immunotherapy for ulcerative colitis
Diet effects on colonic health influence the efficacy of Bin1 mAb immunotherapy for ulcerative colitis Open
View article: Gut-brain connections in neurodegenerative disease: immunotherapeutic targeting of Bin1 in inflammatory bowel disease and Alzheimer’s disease
Gut-brain connections in neurodegenerative disease: immunotherapeutic targeting of Bin1 in inflammatory bowel disease and Alzheimer’s disease Open
Longer lifespan produces risks of age-associated neurodegenerative disorders such as Alzheimer’s disease (AD), which is characterized by declines in memory and cognitive function. The pathogenic causes of AD are thought to reflect a progre…
View article: Dandelion Has Successfully Adapted to Grow in Suburban Environments
Dandelion Has Successfully Adapted to Grow in Suburban Environments Open
Dandelion ( Taraxacum officinale G.H. Weber ex Wiggers) is a perennial herbaceous plant, generally considered as a weed, often seen blooming in the temperate areas during early spring. Dandelions growing in nature reserves or wastelands ar…
View article: Dandelion Has Successfully Adapted to Grow in Different Environments
Dandelion Has Successfully Adapted to Grow in Different Environments Open
Dandelion ( Taraxacum officinale G.H. Weber ex Wiggers) is a perennial herbaceous plant, generally considered as a weed, often seen blooming in the temperate areas during early spring. Dandelions growing in nature reserves or wastelands ar…
View article: Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross-presentation
Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross-presentation Open
To leverage complementary mechanisms for cancer cell removal, we developed a novel cell engineering and therapeutic strategy co-opting phagocytic clearance and antigen presentation activity into T cells. We engineered a chimeric engulfment…
View article: Diet effects on colonic health influence the efficacy of Bin1 mAb immunotherapy for ulcerative colitis
Diet effects on colonic health influence the efficacy of Bin1 mAb immunotherapy for ulcerative colitis Open
Ulcerative colitis (UC) is an idiopathic disease of the large intestine linked to high fat-high protein diets, a dysbiotic microbiome, and a metabolome linked to diet and/or aberrant circadian rhythms associated with poor sleeping patterns…
View article: Supplementary Tables S1-S2 from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization
Supplementary Tables S1-S2 from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization Open
Supplementary Tables S1-S2
View article: Data from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization
Data from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization Open
In addition to immunosuppression, it is generally accepted that myeloid-derived suppressor cells (MDSC) also support tumor angiogenesis. The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) has been implicated in promoting…
View article: Supplementary Figures S1-S12 from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization
Supplementary Figures S1-S12 from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization Open
Supplementary Figures S1-S12
View article: Data from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization
Data from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization Open
In addition to immunosuppression, it is generally accepted that myeloid-derived suppressor cells (MDSC) also support tumor angiogenesis. The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) has been implicated in promoting…
View article: Supplementary Figures S1-S12 from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization
Supplementary Figures S1-S12 from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization Open
Supplementary Figures S1-S12
View article: Supplementary Tables S1-S2 from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization
Supplementary Tables S1-S2 from IDO1 Signaling through GCN2 in a Subpopulation of Gr-1<sup>+</sup> Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization Open
Supplementary Tables S1-S2
View article: Mapping the Accessory Proteins (Orfs) of Severe Acute Respiratory Syndrome Coronavirus 2
Mapping the Accessory Proteins (Orfs) of Severe Acute Respiratory Syndrome Coronavirus 2 Open
Background: The coronavirus disease 2019 (COVID-19) pandemic, first observed in December 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has influenced every individual on the planet. The virus has influenced o…
View article: Mapping the Accessory Proteins (Orfs) of Severe Acute Respiratory Syndrome Coronavirus 2
Mapping the Accessory Proteins (Orfs) of Severe Acute Respiratory Syndrome Coronavirus 2 Open
The COVID-19 pandemic first observed in December 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has influenced every individual on the planet. The virus has influenced our lifestyle, education, economy and the …
View article: Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment
Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment Open
Ulcerative colitis (UC) is a common chronic disease of the large intestine. Current anti-inflammatory drugs prescribed to treat this disease have limited utility due to significant side-effects. Thus, immunotherapies for UC treatment are s…