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View article: Weight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry
Weight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry Open
Introduction Optimal venous thromboembolism (VTE) enoxaparin prophylaxis dosing remains elusive. Weight-based (WB) dosing safely increases anti-factor Xa levels without the need for routine monitoring but it is unclear if it leads to lower…
View article: Serial “death diamond” TEGs are a bedside indicator of futile resuscitation during massive transfusion
Serial “death diamond” TEGs are a bedside indicator of futile resuscitation during massive transfusion Open
Serial DDs could serve as rapid check points to gauge the likelihood of success of continued resuscitation. Loudon et al.’s work combined with the use of serial DDs may serve as building blocks toward a trial using VETs to predict continue…
View article: Challenging Traditional Paradigms in Posttraumatic Pulmonary Thromboembolism
Challenging Traditional Paradigms in Posttraumatic Pulmonary Thromboembolism Open
To our knowledge, this CLOTT study is the largest prospective investigation in the world that focuses on posttraumatic PT. The study suggests that most pulmonary clots are not embolic but rather result from inflammation, endothelial injury…
View article: Viscoelastic Testing and Coagulopathy of Traumatic Brain Injury
Viscoelastic Testing and Coagulopathy of Traumatic Brain Injury Open
A unique coagulopathy often manifests following traumatic brain injury, leading the clinician down a difficult decision path on appropriate prophylaxis and therapy. Conventional coagulation assays—such as prothrombin time, partial thrombop…