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High-Affinity Probes for Androgen Receptor Imaging: From Cells and <i>In Silico</i> Modeling to Whole-Body Fluorescent Applications Open

Saheed Ayodeji, Yaroslav Balytskyi, Destina Unaegbu, Allison Ingman, Christopher V. Kelly , et al. · 2025

Castrate-resistant prostate cancer (CRPC) is driven by androgen receptor (AR) signaling. Imaging tools to monitor AR signaling dynamics are a high-priority goal. Here, we introduce ARi-FL, a series of visible- and near-infrared fluorescent…

High-affinity probes for androgen receptor imaging: from cells to whole-body fluorescent applications Open

Saheed Ayodeji, Sheryl Roberts, Allison Ingman, Sheryl Roberts · 2025

The hallmark of castrate-resistant prostate cancer (CRPC) is its continued dependence on androgen receptor (AR) signaling for survival. CRPC is challenging to diagnose, as it often manifests with few to no symptoms. Imaging agents that all…

High-affinity probes for androgen receptor imaging: from cells to whole-body fluorescent applications Open

Saheed Ayodeji, Sheryl Roberts, Destina Unaegbu, Allison Ingman · 2025

The hallmark of castrate-resistant prostate cancer (CRPC) is its continued dependence on androgen receptor (AR) signaling for survival. CRPC is challenging to diagnose, as it often manifests with few to no symptoms. Imaging agents that all…

Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent Open

Dauren Adilbay, Junior Gonzales, Marianna Zazhytska, Paula Demétrio De Souza França, Sheryl Roberts , et al. · 2024

Despite the recent advances in understanding the mechanisms of olfaction, no tools are currently available to noninvasively identify loss of smell. Because of the substantial increase in patients presenting with coronavirus disease 2019-re…

Ambient Light Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via the pH Low-Insertion Peptide Conjugated to Indocyanine Green Open

Benedict Mc Larney, Mijin Kim, Sheryl Roberts, Magdalena Skubal, Hsiao‐Ting Hsu , et al. · 2023

Shortwave infrared (900-1,700 nm) fluorescence imaging (SWIRFI) has shown significant advantages over visible (400-650 nm) and near-infrared (700-900 nm) fluorescence imaging (reduced autofluorescence, improved contrast, tissue resolution,…

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Purpose:We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility of PET imaging with ¹⁸F-PARPi in patients with head and neck cancer.Patients and Methods:Eleven patients with ne…

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Purpose:We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility of PET imaging with ¹⁸F-PARPi in patients with head and neck cancer.Patients and Methods:Eleven patients with ne…

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with <sup>18</sup>F-PARPi in Patients with Head and Neck Cancer Open

Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts , et al. · 2023

Supplementary Data from Safety and Feasibility of PARP1/2 Imaging with ¹⁸F-PARPi in Patients with Head and Neck Cancer

Preclinical shortwave infrared tumor screening and resection via pHLIP ICG under ambient lighting conditions Open

Benedict Mc Larney, Mijin Kim, Sheryl Roberts, Magdalena Skubal, Hsiao‐Ting Hsu , et al. · 2022

There is a critical need to improve optical imaging that will lead to its widespread acceptance for routine clinical procedures. Shortwave infrared (SWIR, 900–1700nm) imaging has demonstrated clear advantages over visible and near-infrared…

Polyethylene Glycol 3350 (PEG 3350) as a Practical Vehicle for Rapid Reconstitution of PARPi-FL Formulations for Clinical Use Open

Paula Demétrio De Souza França, Tara Viray, Sheryl Roberts, Alexa Michel, Márcio Abrahão , et al. · 2022

Combined PARP1-Targeted Nuclear Contrast and Reflectance Contrast Enhance Confocal Microscopic Detection of Basal Cell Carcinoma Open

Aditi Sahu, José F. Cordero, Xiancheng Wu, Susanne Kossatz, Ucalene Harris , et al. · 2021

Reflectance confocal microscopy (RCM) with endogenous backscattered contrast can noninvasively image basal cell carcinomas (BCCs) in skin. However, BCCs present with high nuclear density, and the relatively weak backscattering from nuclei …

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