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View article: Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens
Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens Open
Cardiac fibrosis is mediated by the persistent activity of myofibroblasts, which differentiates from resident cardiac fibroblasts in response to tissue damage and stress signals. The signaling pathways and transcription factors regulating …
View article: Identification of Epigenetic Regulators of Fibrotic Transformation in Cardiac Fibroblasts Through Bulk and Single-Cell CRISPR Screens
Identification of Epigenetic Regulators of Fibrotic Transformation in Cardiac Fibroblasts Through Bulk and Single-Cell CRISPR Screens Open
Cardiac fibrosis is mediated by the persistent activity of myofibroblasts, which differentiate from resident cardiac fibroblasts in response to tissue damage and stress signals. The signaling pathways and transcription factors regulating f…
View article: Estrategias financieras y aspectos fiscales del sector empresarial en Colombia
Estrategias financieras y aspectos fiscales del sector empresarial en Colombia Open
En el contexto de las reformas fiscales, las pequeñas y medianas empresas (pymes) enfrentan desafíos y oportunidades únicas, especialmente con la introducción de regímenes simplificados de tributación. En este sentido, el libro hace un aná…
View article: Dual Targeting of Pim and <scp>PI3</scp> Kinases in Mature T‐Cell Lymphoma
Dual Targeting of Pim and <span>PI3</span> Kinases in Mature T‐Cell Lymphoma Open
Provirus Integration site for Moloney leukemia virus (Pim) family members are well‐known oncogenes, with an expression that is restricted to few cell types including hematopoietic cells in adult organisms, making it a promising target for …
View article: Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens
Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens Open
Cardiac fibrosis is mediated by the persistent activity of myofibroblasts, which differentiate from resident cardiac fibroblasts in response to tissue damage and stress signals. The signaling pathways and transcription factors regulating f…
View article: 359 Preclinical models for T-Plex, a customized multiplexed TCR-T cell therapy addressing intra-tumor antigen and HLA heterogeneity
359 Preclinical models for T-Plex, a customized multiplexed TCR-T cell therapy addressing intra-tumor antigen and HLA heterogeneity Open
View article: SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis
SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis Open
View article: SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis
SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis Open
SUMMARY SETD8 is a methyltransferase that is overexpressed in several cancers, which monomethylates H4K20 as well as other non-histone targets such as PCNA or p53. We here report novel SETD8 inhibitors, which were discovered while trying t…
View article: Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits
Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits Open
View article: BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS
BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS Open
A high percentage of patients with brain metastases frequently develop neurocognitive symptoms, however understanding how brain metastasis co-opt the function of neuronal circuits beyond a mass effect remains unknown. We report a comprehen…
View article: A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis Open
We report a medium-throughput drug-screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metastas…
View article: Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors
Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors Open
The PI3K/AKT/mTOR and PIM kinase pathways contribute to the development of several hallmarks of cancer. Cotargeting of these pathways has exhibited promising synergistic therapeutic effects in liquid and solid tumor types. To identify mole…
View article: Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors
Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors Open
View article: Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases Open
View article: 42. IDENTIFICATION OF BRAIN METASTASIS VULNERABILITIES USING METPLATFORM
42. IDENTIFICATION OF BRAIN METASTASIS VULNERABILITIES USING METPLATFORM Open
The diagnosis of brain metastasis involves high morbidity and mortality and remains an unmet clinical need in spite of being the most common tumor in the brain. Exclusion of these cancer patients from clinical trials is a major cause of th…
View article: Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells
Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells Open
Despite significant efforts to improve pancreatic ductal adenocarcinoma (PDAC) clinical outcomes, overall survival remains dismal. The poor response to current therapies is partly due to the existence of pancreatic cancer stem cells (PaCSC…
View article: Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors
Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors Open
View article: Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer
Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer Open
The proviral integration of Moloney virus (PIM) family of protein kinases are overexpressed in many haematological and solid tumours. PIM kinase expression is elevated in PI3K inhibitor-treated breast cancer samples, suggesting a major res…
View article: Anti‐tumor effects of <scp>PIM</scp> / <scp>PI</scp> 3K/ <scp>mTOR</scp> triple kinase inhibitor <scp>IBL</scp> ‐302 in neuroblastoma
Anti‐tumor effects of <span>PIM</span> / <span>PI</span> 3K/ <span>mTOR</span> triple kinase inhibitor <span>IBL</span> ‐302 in neuroblastoma Open
Corrigendum9 January 2020Open Access Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma Sofie Mohlin Sofie Mohlin orcid.org/0000-0002-2458-3963 Search for more papers by this author Karin Hansson Karin Han…
View article: The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status Open
Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To proactively identify resistan…
View article: Anti‐tumor effects of <scp>PIM</scp> / <scp>PI</scp> 3K/ <scp>mTOR</scp> triple kinase inhibitor <scp>IBL</scp> ‐302 in neuroblastoma
Anti‐tumor effects of <span>PIM</span> / <span>PI</span> 3K/ <span>mTOR</span> triple kinase inhibitor <span>IBL</span> ‐302 in neuroblastoma Open
The PI3K pathway is a major driver of cancer progression. However, clinical resistance to PI3K inhibition is common. IBL-302 is a novel highly specific triple PIM, PI3K, and mTOR inhibitor. Screening IBL-302 in over 700 cell lines represen…
View article: Multiple cancer pathways regulate telomere protection
Multiple cancer pathways regulate telomere protection Open
Telomeres are considered as universal anti-cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cance…
View article: Acknowledgments
Acknowledgments Open
View article: Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors
Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors Open
View article: An attempt to select non-genetic variation in resistance to starvation and reduced chill coma recovery time in <i>Drosophila melanogaster</i>
An attempt to select non-genetic variation in resistance to starvation and reduced chill coma recovery time in <i>Drosophila melanogaster</i> Open
Phenotypic variance is attributed to genetic and non-genetic factors, and only the former are supposed to be inherited and thus suitable for the action of selection. Although increasing amounts of data suggest that non-genetic variability …
View article: Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts Open
View article: Identification of novel PI3K inhibitors through a scaffold hopping strategy
Identification of novel PI3K inhibitors through a scaffold hopping strategy Open
View article: Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy
Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy Open
View article: PI3Kα inhibition reduces obesity in mice
PI3Kα inhibition reduces obesity in mice Open
Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. The best known health beneficial effects of reduced PI3K are related to metabolism and include increased energy expenditu…
View article: Expresión recombinante del antígeno tE2 del virus de la diarrea viral bovina (BVDV) en plantas de Nicotiana tabacum y estudio de su bioseguridad en ratones
Expresión recombinante del antígeno tE2 del virus de la diarrea viral bovina (BVDV) en plantas de Nicotiana tabacum y estudio de su bioseguridad en ratones Open
Fil: Laguia Becher, Melina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Parque Centenario. Instituto de Ciencia y Tecnologia Dr. Cesar Milstein. Fundacion Pablo Cassara. Instituto de C…