Explanipedia

Bisretinoids as a Source of Early Photoreceptor Pathology in Stargardt Disease Open

Nathan L. Mata, Shi-Jun Weng, Michel Michaelides, Peter Charbel Issa, Mathieu Quinodoz , et al. · 2025

Background: Stargardt disease (STGD1) due to bi-allelic mutations in the ABCA4 gene is the most frequent single-gene retinal disease with a genetic prevalence of about 1 in 7,000. Pathology in STGD1 is due to dysfunction of a retina-specif…

Multi-omics analysis reveals a novel <i>NFE2L3</i> variant impairing choroidal vasculature development in high myopia and myopic maculopathy Open

Jiangnan He, Luyao Ye, Hannan Xu, Huanjie Yang, Juan Shen , et al. · 2024

Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes Open

Yuqi Shao, Yongchen Wang, Lu Wang, Hang-Ze Ruan, Yunfeng Liu , et al. · 2024

JOURNAL/nrgr/04.03/01300535-202602000-00048/figure1/v/2025-05-17T081902Z/r/image-tiff Diabetic retinopathy is a prominent cause of blindness in adults, with early retinal ganglion cell loss contributing to visual dysfunction or blindness. …

A non-image-forming visual circuit mediates the innate fear of heights in male mice Open

Wei Shang, Shuangyi Xie, Wenbo Feng, Zhuangzhuang Li, Jingyan Jia , et al. · 2024

The neural basis of fear of heights remains largely unknown. In this study, we investigated the fear response to heights in male mice and observed characteristic aversive behaviors resembling human height vertigo. We identified visual inpu…

Exendin-4 promotes retinal ganglion cell survival and function by inhibiting calcium channels in experimental diabetes Open

Yongchen Wang, Lu Wang, Yuqi Shao, Shi-Jun Weng, Xiong‐Li Yang , et al. · 2023

Progressive damage of retinal ganglion cells (RGCs) is observed in early diabetic retinopathy. Intracellular Ca²⁺ overload mediated by Ca²⁺ influx through voltage-gated Ca²⁺ channels (VGCCs) is involved in …

A non-image-forming visual circuit mediates the innate fear of heights Open

Wei Shang, Shuangyi Xie, Wenbo Feng, Zhuangzhuang Li, Jingyan Jia , et al. · 2023

The neural basis of fear of heights remains largely unknown. In this study, we investigated the fear response to heights in mice and observed characteristic aversive behaviors resembling human height vertigo. We identified visual input as …

Potential Choroidal Mechanisms Underlying Atropine's Antimyopic and Rebound Effects: A Mediation Analysis in a Randomized Clinical Trial Open

Hannan Xu, Luyao Ye, Yajun Peng, Tao Yu, Shanshan Li , et al. · 2023

One percent atropine induced choroidal thickening by increasing both LA and SA, while 0.01% atropine had little choroidal response. The choroidal changes following 1% atropine treatment diminished after switching to 0.01% atropine. TCA, bu…

Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit Open

Ge Wang, Yunfeng Liu, Zhe Yang, Chen-Xi Yu, Qiuping Tong , et al. · 2023

Light modulates mood through various retina-brain pathways. We showed that mice treated with short-term acute bright light exposure displayed anxiety-related phenotypes in a prolonged manner even after the termination of the exposure. Such…

Cross-modal modulation gates nociceptive inputs in Drosophila Open

Geng Pan, Ruonan Li, Guozhong Xu, Shi-Jun Weng, Xiong‐Li Yang , et al. · 2023

Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling Open

Songhui Hu, Yurong Wang, Xu Han, Min Dai, Yongxing Zhang , et al. · 2022

Background Oxytocin, secreted by oxytocin neurons in the hypothalamus, is an endogenous neuropeptide involved in modulating multiple sensory information processing pathways, and its roles in the brain have been associated with prosocial, m…

The role of ipRGCs in ocular growth and myopia development Open

Ailin Liu, Yunfeng Liu, Ge Wang, Yuqi Shao, Chen-Xi Yu , et al. · 2022

The increasing global prevalence of myopia calls for elaboration of the pathogenesis of this disease. Here, we show that selective ablation and activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in developing mice i…

Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia Open

Kang-Wei Qian, Yunyun Li, Xiaohua Wu, Xue Gong, Ailin Liu , et al. · 2022

Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells Open

Tao Zhang, Hang-Ze Ruan, Yongchen Wang, Yuqi Shao, Wei Zhou , et al. · 2022

Glucagon-like peptide-1 (GLP-1) is expressed in retinal neurons, but its role in the retina is largely unknown. Here, we demonstrated that GLP-1 or the GLP-1 receptor (GLP-1R; a G protein-coupled receptor) agonist exendin-4 suppressed γ-am…

Vision restoration in photoreceptor-degenerated mice and macaque monkeys using nanowires Open

Ruyi Yang, Peng Zhao, Liyang Wang, Chenli Feng, Peng Chen , et al. · 2022

Photoreceptor degeneration diseases, such as retinitis pigmentosa and age-related macular degeneration, are major causes of blindness. Photovoltaic devices or materials activates retinal cells in response to light, hence are promising reti…

Vision restoration in photoreceptor-degenerated mice and macaque monkeys using nanowires Open

Jiayi Zhang, Ruyi Yang, Peng Zhao, Chenli Feng, Liyang Wang , et al. · 2021

Photoreceptor degeneration diseases, such as retinitis pigmentosa and age-related macular degeneration, are major causes of blindness. Here we evaluate the performance of Au nanoparticle-coated titania (TiO2-x) nanowire (NW) arrays as arti…

Near-infrared manipulation of multiple neuronal populations via trichromatic upconversion Open

Xuan Liu, Heming Chen, Yi‐Ting Wang, Yueguang Si, Hongxin Zhang , et al. · 2021

Orexin-A differentially modulates inhibitory and excitatory synaptic transmission in rat inner retina Open

Hang-Ze Ruan, Liqing Wang, Fei Yuan, Shi-Jun Weng, Yong‐Mei Zhong · 2021

In this work, modulation by orexin-A of the release of glutamate and GABA from bipolar and amacrine cells respectively was studied by examining the effects of the neuropeptide on miniature excitatory postsynaptic currents (mEPSCs) and mini…

Cell-Subtype-Specific Remodeling of Intrinsically Photosensitive Retinal Ganglion Cells in Streptozotocin-Induced Diabetic Mice Open

Ada Admin, Wei‐Yi Chen, Xu Han, Ling-Jie Cui, Chenxi Yu , et al. · 2021

Recent evidence suggests that melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), a neuronal class regulating non-image forming (NIF) vision and generally thought to be injury-resistant, are dysfunctional in…

Cell-Subtype-Specific Remodeling of Intrinsically Photosensitive Retinal Ganglion Cells in Streptozotocin-Induced Diabetic Mice Open

Wei‐Yi Chen, Xu Han, Ling-Jie Cui, Chenxi Yu, Wenlong Sheng , et al. · 2021

Recent evidence suggests that melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), a neuronal class regulating non-image forming (NIF) vision and generally thought to be injury-resistant, are dysfunctional in…

Cell-Subtype-Specific Remodeling of Intrinsically Photosensitive Retinal Ganglion Cells in Streptozotocin-Induced Diabetic Mice Open

Wei‐Yi Chen, Xu Han, Ling-Jie Cui, Chenxi Yu, Wenlong Sheng , et al. · 2021

Recent evidence suggests that melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), a neuronal class regulating non-image forming (NIF) vision and generally thought to be injury-resistant, are dysfunctional in…

Cell-Subtype-Specific Remodeling of Intrinsically Photosensitive Retinal Ganglion Cells in Streptozotocin-Induced Diabetic Mice Open

Weiyi Chen, Xu Han, Ling-Jie Cui, Chen-Xi Yu, Wenlong Sheng , et al. · 2021

Recent evidence suggests that melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), a neuronal class regulating non-image forming (NIF) vision and generally thought to be injury resistant, are dysfunctional in…

Orexin-A Intensifies Mouse Pupillary Light Response by Modulating Intrinsically Photosensitive Retinal Ganglion Cells Open

Wei Zhou, Liqin Wang, Yuqi Shao, Xu Han, Chen-Xi Yu , et al. · 2021

We show for the first time that the neuropeptide orexin modulates pupillary light response, a non-image-forming visual function, in mice of either sex. Intravitreal injection of the orexin receptor (OXR) antagonist TCS1102 and orexin-A red…

Immunohistological Localization of Mel1a Melatonin Receptor in Pigeon Retina Open

Wenlong Sheng, Shi-Jun Weng, Fĕi Li, Yun Zhang, Qiuxia He , et al. · 2021

The finding that multiple types of retinal cells express the Mel1a receptor provides a new neurobiological basis for the participation of melatonin in the regulation of retinal functions through activating the Mel1a receptor.

Visual Cortex Encodes Timing Information in Humans and Mice Open

Qingpeng Yu, Zedong Bi, Zixuan Wei, Biao Yan, Heming Chen , et al. · 2021

Supplementary Material for: Stronger Association of Albuminuria with the Risk of Vascular Complications than Estimated Glomerular Filtration Rate in Type 2 Diabetes Open

Xiumei Hong, Lan Huang, Yingying Zhang, Xinghua Shen, Shi-Jun Weng , et al. · 2021

Introduction: Albuminuria is a risk factor for macro- and microvascular complications of type 2 diabetes (T2D).With an increasing trend of normoalbuminuria, however, of the 2 predictors – estimated glomerular filtration rate …

Aerobic exercise delays retinal ganglion cell death after optic nerve injury Open

Yuanyuan He, Lu Wang, Tao Zhang, Shi-Jun Weng, Jian Lü , et al. · 2020

Aerobic exercise has been shown to play a crucial role in preventing neurological diseases and improving cognitive function. In the present study, we investigated the effect of treadmill training on retinal ganglion cells (RGCs) following …

nGnG Amacrine Cells and Brn3b-negative M1 ipRGCs are Specifically Labeled in the ChAT-ChR2-EYFP Mouse Open

Ling-Jie Cui, Wen‐Hao Chen, Ailin Liu, Xu Han, Shi-Xiang Jiang , et al. · 2020

The ChAT-ChR2-EYFP retina exhibits ectopic, but functional, transgene expression in nGnG ACs and SCN-innervating M1 ipRGCs, thus providing an ideal tool to achieve efficient labeling and optogenetic manipulation of these cells.

Morphological alterations of intrinsically photosensitive retinal ganglion cells after ablation of mouse photoreceptors with selective photocoagulation Open

Xiao-Sha Wu, Yongchen Wang, Tingting Liu, Lu Wang, Xinghuai Sun , et al. · 2019

In this work, we investigated changes in the morphology of intrinsically photosensitive retinal ganglion cells (ipRGCs), M1 subtype, and pupillary light reflex following local and selective ablation of photoreceptors in mice. Laser photoco…

Orexin-A potentiates intrinsic light responses of intrinsically photosensitive retinal ganglion cells in mouse retina Open

Yong‐Mei Zhong, Shi-Jun Weng, Wei Zhou, Xiong‐Li Yang · 2019

A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles Open

Hao Zheng, Zhitao Zhang, Su Jiang, Biao Yan, Xiang Shi , et al. · 2019

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