Shibasish Chowdhury
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View article: Lipid Armor Loaded with Doxylamine and Gemfibrozil for Glioblastoma Therapy: Particle Engineering and Multidimensional Two-Dimensional/Three-Dimensional Antitumor Efficacy
Lipid Armor Loaded with Doxylamine and Gemfibrozil for Glioblastoma Therapy: Particle Engineering and Multidimensional Two-Dimensional/Three-Dimensional Antitumor Efficacy Open
View article: Cisplatin-induced oxidative stress regulates YAP to modulate epigenome promoting survival of osteosarcoma cells
Cisplatin-induced oxidative stress regulates YAP to modulate epigenome promoting survival of osteosarcoma cells Open
The widely used chemotherapeutic drug cisplatin (CDDP) is an integral part of the pre-operative chemotherapy protocol for high-grade osteosarcoma (OS). However, despite an aggressive treatment regimen, drug refractoriness is a major hindra…
View article: Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy
Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy Open
View article: S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis
S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis Open
Nitric oxide (NO), a versatile bio-active molecule modulates cellular functions through diverse mechanisms including S-nitrosylation of proteins. Herein, we report S-nitrosylation of selected cysteine residues of EZH2 in endothelial cells,…
View article: Inhibition of autophagy in platelets as a therapeutic strategy preventing hypoxia induced thrombosis
Inhibition of autophagy in platelets as a therapeutic strategy preventing hypoxia induced thrombosis Open
Hypoxia triggers activation of platelets, leading to thrombosis. If not addressed clinically, it can cause severe complications and fatal consequences. The current treatment regime for thrombosis is often palliative and include long-term a…
View article: LncRNA HULC augments high glucose‐associated pancreatic cancer progression and drug resistance by enhancing YAP activity and autophagy
LncRNA HULC augments high glucose‐associated pancreatic cancer progression and drug resistance by enhancing YAP activity and autophagy Open
Background Information: One of the confounding factors in pancreatic cancer (PC) pathogenesis is hyperglycemia. The molecular mechanism by which high glucose (HG) influences PC severity is poorly understood. Our investigation delved into t…
View article: Chloroquine attenuates hypoxia-mediated autophagy to curb thrombosis- an<i>ex vivo</i>and<i>in vivo</i>study
Chloroquine attenuates hypoxia-mediated autophagy to curb thrombosis- an<i>ex vivo</i>and<i>in vivo</i>study Open
Background Hypoxia can trigger the activation of blood platelets, leading to thrombosis. If not addressed clinically, it can cause severe complications and fatal consequences as well. The current treatment regime for thrombosis is often pa…
View article: S-nitrosylation of EZH2 at C329 and C700 interplay with PRC2 complex assembly, methyltransferase activity, and EZH2 stability to regulate endothelial functions
S-nitrosylation of EZH2 at C329 and C700 interplay with PRC2 complex assembly, methyltransferase activity, and EZH2 stability to regulate endothelial functions Open
Nitric oxide (NO), a versatile bio-active molecule modulates cellular function through diverse mechanisms including S-nitrosylation of proteins. However, the role of this post-translational modification in regulating epigenetic pathways wa…
View article: Nature-inspired Enzyme engineering and sustainable catalysis: biochemical clues from the world of plants and extremophiles
Nature-inspired Enzyme engineering and sustainable catalysis: biochemical clues from the world of plants and extremophiles Open
The use of enzymes to accelerate chemical reactions for the synthesis of industrially important products is rapidly gaining popularity. Biocatalysis is an environment-friendly approach as it not only uses non-toxic, biodegradable, and rene…
View article: Regulation of shelterin proteins TERF2IP and TRF2 by H3K4me3-p65 axis drives hyperglycemia dependent endothelial senescence
Regulation of shelterin proteins TERF2IP and TRF2 by H3K4me3-p65 axis drives hyperglycemia dependent endothelial senescence Open
Background Endothelial senescence has been linked to several cardiovascular diseases. Dysregulation of proteins of the shelterin complex including TRF2 and TERF2IP causes senescence as it hampers DNA repair and cell proliferation. However,…
View article: Transforming growth factor- β mediated regulation of epigenome is required for epithelial to mesenchymal transition associated features in liver cancer cells
Transforming growth factor- β mediated regulation of epigenome is required for epithelial to mesenchymal transition associated features in liver cancer cells Open
Hepatocellular carcinoma (HCC) frequently unfolds under an inflammatory condition, which is a hub for a plethora of cytokines. A better understanding of the cytokine functions and their contributions to disease development is key to design…
View article: Interleukin-6 Induced Proliferation Is Attenuated by Transforming Growth Factor-β-Induced Signaling in Human Hepatocellular Carcinoma Cells
Interleukin-6 Induced Proliferation Is Attenuated by Transforming Growth Factor-β-Induced Signaling in Human Hepatocellular Carcinoma Cells Open
Hepatocellular carcinoma (HCC) is often associated with an inflammatory setting. A plethora of cytokines are secreted in this milieu, actively contributing to the progression of the disease; however, the extent of cytokine interaction and …
View article: Silver nanoparticle-induced alteration of mitochondrial and ER homeostasis affects human breast cancer cell fate
Silver nanoparticle-induced alteration of mitochondrial and ER homeostasis affects human breast cancer cell fate Open
View article: A genome-wide expression profile of noncoding RNAs in human osteosarcoma cells as they acquire resistance to cisplatin
A genome-wide expression profile of noncoding RNAs in human osteosarcoma cells as they acquire resistance to cisplatin Open
Background Recurrence after cisplatin therapy is one of the major hindrances in the management of cancer. This necessitates a deeper understanding of the molecular signatures marking the acquisition of resistance. We therefore modeled the …
View article: Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells
Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells Open
View article: Common and Unique microRNAs in Multiple Carcinomas Regulate Similar Network of Pathways to Mediate Cancer Progression
Common and Unique microRNAs in Multiple Carcinomas Regulate Similar Network of Pathways to Mediate Cancer Progression Open
View article: Transcriptomic analysis associated with reversal of cisplatin sensitivity in drug resistant osteosarcoma cells after a drug holiday
Transcriptomic analysis associated with reversal of cisplatin sensitivity in drug resistant osteosarcoma cells after a drug holiday Open
View article: Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease
Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease Open
View article: Analysis of seven putative Na+/H+ antiporters of Arthrospira platensis NIES-39 using transcription profiling and in silico studies: an indication towards alkaline pH acclimation
Analysis of seven putative Na+/H+ antiporters of Arthrospira platensis NIES-39 using transcription profiling and in silico studies: an indication towards alkaline pH acclimation Open
View article: Evolution of endonuclease IV protein family: an in silico analysis
Evolution of endonuclease IV protein family: an in silico analysis Open
View article: Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells
Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells Open
Mutations in p53, especially gain of function (GOF) mutations, are highly frequent in lung cancers and are known to facilitate tumor aggressiveness. Yet, the links between mutant GOF-p53 and lung cancers are not well established. In the pr…
View article: Integrative analysis reveals common microRNAs regulating similar network of pathways dysregulated across multiple carcinomas
Integrative analysis reveals common microRNAs regulating similar network of pathways dysregulated across multiple carcinomas Open
View article: Drug Tolerant Cells: An Emerging Target With Unique Transcriptomic Features
Drug Tolerant Cells: An Emerging Target With Unique Transcriptomic Features Open
Long-term outcome of cancer therapy is often severely perturbed by the acquisition of drug resistance. Recent evidence point toward the survival of a subpopulation of tumor cells under acute drug stress that over time can re-populate the t…
View article: A global transcriptomic pipeline decoding core network of genes involved in stages leading to acquisition of drug-resistance to cisplatin in osteosarcoma cells
A global transcriptomic pipeline decoding core network of genes involved in stages leading to acquisition of drug-resistance to cisplatin in osteosarcoma cells Open
Motivation Traditional cancer therapy is focused on eradicating fast proliferating population of tumor cells. However, existing evidences suggest survival of sub-population of cancer cells that can resist chemotherapy by entering a ‘persis…
View article: Analysis of seven putative Na<sup>+</sup>/H<sup>+</sup>antiporters of<i>Arthrospira platensis</i>NIES-39 using transcription profiling and<i>In-silico</i>studies: an indication towards alkaline pH acclimation
Analysis of seven putative Na<sup>+</sup>/H<sup>+</sup>antiporters of<i>Arthrospira platensis</i>NIES-39 using transcription profiling and<i>In-silico</i>studies: an indication towards alkaline pH acclimation Open
Na + /H + antiporters mediated pH regulation is one of the known mechanism(s), which advocates a possible role of the antiporters in the alkaline pH tolerance of Arthrospira platensis NIES-39 too. Seven putative Na + /H + antiporters have …