Shichao Du
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View article: Crystal Form Investigation and Morphology Control of Salbutamol Sulfate via Spherulitic Growth
Crystal Form Investigation and Morphology Control of Salbutamol Sulfate via Spherulitic Growth Open
Salbutamol sulfate is a selective β2-receptor agonist used to treat asthma and chronic obstructive pulmonary disease. The crystals of salbutamol sulfate usually appear as needles with a relatively large aspect ratio, showing poor powder pr…
View article: Unveiling the effect of stress on vacancy diffusion isotropy at high temperature in Ni-Re Systems: Insights from atomic simulations
Unveiling the effect of stress on vacancy diffusion isotropy at high temperature in Ni-Re Systems: Insights from atomic simulations Open
Stress-affected vacancy diffusion significantly impacts the element distributions in Ni-based single-crystal (SX) superalloys, determining their precipitate coarsening and creep behaviors under service conditions consequently. Rhenium (Re)…
View article: Solvates and Polymorphs of Axitinib: Characterization and Phase Transformation
Solvates and Polymorphs of Axitinib: Characterization and Phase Transformation Open
Axitinib (AXTN) is an oral tyrosine kinase inhibitor for the treatment of early to advanced renal cell carcinoma. In this work, solvates of AXTN were prepared in five solvents and subjected to desolvation treatment. The crystal form A of A…
View article: Prevention of Crystal Agglomeration: Mechanisms, Factors, and Impact of Additives
Prevention of Crystal Agglomeration: Mechanisms, Factors, and Impact of Additives Open
Crystal agglomeration is a common phenomenon for most chemicals and pharmaceuticals. The formation of agglomerates usually lowers product purity and generates a broad particle size distribution. This review focuses on preventing agglomerat…
View article: Effect of Additives on the Morphology of γ-Aminobutyric Acid Crystals
Effect of Additives on the Morphology of γ-Aminobutyric Acid Crystals Open
The effect of surfactant, polymer, and tailor-made additives on the crystallization of γ-aminobutyric acid (GABA) was studied in this work. Cooling crystallization of GABA in water yielded plate-like crystals. In the presence of sodium ste…
View article: Determination and Correlation of Solubility of <i>N</i>-Acetylglucosamine in Four Aqueous Binary Solvents from 283.15 to 323.15 K
Determination and Correlation of Solubility of <i>N</i>-Acetylglucosamine in Four Aqueous Binary Solvents from 283.15 to 323.15 K Open
N-Acetylglucosamine (NAG) is a significant novel functional monosaccharide with a wide range of potential applications, such as in the medical and cosmetic fields. A gravimetric technique was used to assess the solubility of NAG in water, …
View article: Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives
Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives Open
Glucosamine hydrochloride (GAH) is a kind of natural hexose, which is used to promote the synthesis of mucopolysaccharides and improve the metabolism of articular cartilage. In this paper, the solubility of GAH in pure water and aqueous sy…
View article: Hierarchical Structure of Glucosamine Hydrochloride Crystals in Antisolvent Crystallization
Hierarchical Structure of Glucosamine Hydrochloride Crystals in Antisolvent Crystallization Open
The crystal morphology of glucosamine hydrochloride (GAH) during antisolvent crystallization was investigated in this work. Particles of different shapes, such as plate-like crystals, leaflike clusters, fan-like dendrites, flower-like aggr…
View article: Polymer-mediated and ultrasound-assisted crystallization of ropivacaine: Crystal growth and morphology modulation
Polymer-mediated and ultrasound-assisted crystallization of ropivacaine: Crystal growth and morphology modulation Open
The objective of this research was to modify the crystal shape and size of poorly water-soluble drug ropivacaine, and to reveal the effects of polymeric additive and ultrasound on crystal nucleation and growth. Ropivacaine often grow as ne…
View article: Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K
Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K Open
Metformin hydrochloride (MET·HCl) is one of the most widely used oral hypoglycemic drugs in the world. In addition to hypoglycemic effects, MET·HCl also has anti-inflammatory, anti-tumor, anti-aging, and other effects, showing good efficac…
View article: Subcritical Water Extraction of Natural Products
Subcritical Water Extraction of Natural Products Open
Subcritical water refers to high-temperature and high-pressure water. A unique and useful characteristic of subcritical water is that its polarity can be dramatically decreased with increasing temperature. Therefore, subcritical water can …
View article: Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride Open
Reaction crystallization to produce glycidyl trimethyl ammonium chloride (GTA) via epichlorohydrin with gas-state trimethylamine was investigated. The crystallization process of the GTA gas-liquid reaction was optimized by a seed method. T…
View article: CCDC 1505023: Experimental Crystal Structure Determination
CCDC 1505023: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1505022: Experimental Crystal Structure Determination
CCDC 1505022: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1505021: Experimental Crystal Structure Determination
CCDC 1505021: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Crystal Structure, Stability and Desolvation of the Solvates of Sorafenib Tosylate
Crystal Structure, Stability and Desolvation of the Solvates of Sorafenib Tosylate Open
In this study, three solvates of sorafenib tosylate were obtained from methanol, ethanol and n-methyl-2-pyrrolidone (NMP) after solvate screening and the effect of solvent on the formation of solvate was analyzed. The solvents with high va…
View article: CCDC 1858780: Experimental Crystal Structure Determination
CCDC 1858780: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1858782: Experimental Crystal Structure Determination
CCDC 1858782: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1858784: Experimental Crystal Structure Determination
CCDC 1858784: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1858783: Experimental Crystal Structure Determination
CCDC 1858783: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1858781: Experimental Crystal Structure Determination
CCDC 1858781: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1841531: Experimental Crystal Structure Determination
CCDC 1841531: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1841530: Experimental Crystal Structure Determination
CCDC 1841530: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1561888: Experimental Crystal Structure Determination
CCDC 1561888: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1450418: Experimental Crystal Structure Determination
CCDC 1450418: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …