Shifeng Cao
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View article: HighFold-MeD: a Rosetta distillation model to accelerate structure prediction of cyclic peptides with backbone N-methylation and d-amino acids
HighFold-MeD: a Rosetta distillation model to accelerate structure prediction of cyclic peptides with backbone N-methylation and d-amino acids Open
View article: The Unimodal Distribution Pattern of Soil Organic Carbon Across Elevation Gradients in the Three Gorges Reservoir
The Unimodal Distribution Pattern of Soil Organic Carbon Across Elevation Gradients in the Three Gorges Reservoir Open
Soil organic carbon (SOC) and its active fractions—labile organic carbon (Lab-C), dissolved organic carbon (DOC), and microbial biomass carbon (MBC)—govern soil carbon stability and climate feedback mechanisms. To investigate the distribut…
View article: Quantitative Analyses of Programmed Cell Death (PCD) Relevant Indicators in Postharvest Vegetable
Quantitative Analyses of Programmed Cell Death (PCD) Relevant Indicators in Postharvest Vegetable Open
The measurement of factors related to postharvest programmed cell death (PCD) in vegetables is crucial for understanding the physiological and metabolic pathways involved in vegetable ripening, aging, and stress responses. PCD is an active…
View article: High-throughput sequencing-based analysis of the composition and diversity of endophytic bacterial community in seeds of elite rice resources from Heilongjiang area
High-throughput sequencing-based analysis of the composition and diversity of endophytic bacterial community in seeds of elite rice resources from Heilongjiang area Open
Background and aims Rice is a major staple crop in China, and Heilongjiang Province is a core japonica rice production region. This study aimed to explore core microbiota composition and the influence of host genetic background on microbio…
View article: Transcriptome analysis of exogenous biological stimulants to enhance alkaline resistance and alkali stress response of Camellia oleifera
Transcriptome analysis of exogenous biological stimulants to enhance alkaline resistance and alkali stress response of Camellia oleifera Open
Exogenous biological stimulants (EBS) have made some progress in alleviating non-biological stress. However, the specific mechanism of EBS on Camellia oleifera seedlings under alkaline stress (AS) remains unclear. This study aims to explor…
View article: 182P EDlL3+ CAFs promote lymph node metastasis by disrupting lymphatic endothelial barriers in breast cancer
182P EDlL3+ CAFs promote lymph node metastasis by disrupting lymphatic endothelial barriers in breast cancer Open
View article: The lysosomal LAMTOR-Rag axis functions as a checkpoint for antiviral interferon production
The lysosomal LAMTOR-Rag axis functions as a checkpoint for antiviral interferon production Open
Lysosomes, best known for their nutrient-sensing and degradative roles, have emerged as essential hubs for antiviral defense. While higher organisms depend on type I interferon (IFN) induction for antiviral responses, the mechanism by whic…
View article: Research progress on the food preservation effects exploiting the antifungal properties of thymol
Research progress on the food preservation effects exploiting the antifungal properties of thymol Open
Thymol is a major monoterpene compound from Lamiaceae plants. Thymol exhibits antifungal, antioxidant, and anti-inflammatory properties. Over the past few years, extensive research has underscored the pivotal role of thymol in delay…
View article: Phenotypic Diversity Analysis and Integrative Evaluation of Camellia oleifera Germplasm Resources in Ya’an, Sichuan Province
Phenotypic Diversity Analysis and Integrative Evaluation of Camellia oleifera Germplasm Resources in Ya’an, Sichuan Province Open
As a unique woody oil crop in China, Camellia oleifera Abel. germplasm resources show significant genetic diversity in Ya’an City. This study measured 60 phenotypic traits (32 quantitative, 28 qualitative) of 302 accessions to analyze phen…
View article: Multi-Omics Analysis Provides New Insights into the Interplay Between Gut Microbiota, Fatty Acid Metabolism, and Immune Response in Cultured and Wild Coilia nasus from the Yangtze River Area in China
Multi-Omics Analysis Provides New Insights into the Interplay Between Gut Microbiota, Fatty Acid Metabolism, and Immune Response in Cultured and Wild Coilia nasus from the Yangtze River Area in China Open
To elucidate the interactions among fatty acid metabolism, immune status, and gut microbiota, both cultured and wild Coilia nasus from the Yangtze River were examined in China. The results demonstrated that wild C. nasus exhibited markedly…
View article: Hydrogen-rich water delays post-harvest yellowing in broccoli by inhibiting ethylene and ABA levels, thereby reducing chlorophyll degradation and carotenoid accumulation
Hydrogen-rich water delays post-harvest yellowing in broccoli by inhibiting ethylene and ABA levels, thereby reducing chlorophyll degradation and carotenoid accumulation Open
View article: MeDCycFold: A Rosetta Distillation Model to Accelerate Structure Prediction of Cyclic Peptides with Backbone N-methylation and D-amino Acids
MeDCycFold: A Rosetta Distillation Model to Accelerate Structure Prediction of Cyclic Peptides with Backbone N-methylation and D-amino Acids Open
Cyclic peptides with backbone N-methylated amino acids(BNMeAAs) and D-amino acids(D-AAs) have gained attention for their stability, membrane permeability, and other therapeutic potentials. Currently, Rosetta can predict their structures us…
View article: Asprosin‐FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development
Asprosin‐FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development Open
Alterations in liver metabolism play a pivotal role in the development and progression of metabolic dysfunction‐associated steatotic liver disease (MASLD). Asprosin is reported to be released from white adipose tissue during fasting and ta…
View article: Recent Advances in Betaine: Extraction, Identification, and Bioactive Functions in Human Health
Recent Advances in Betaine: Extraction, Identification, and Bioactive Functions in Human Health Open
Betaine plays a crucial role in regulating the physiological metabolism of plant fruits and exhibits specific biological activities across animals, plants, and microorganisms. This review highlights that betaine can serve as a nutritional …
View article: Association between FIB-4 index and lower extremity arterial disease in MASLD patients: a cross-sectional study
Association between FIB-4 index and lower extremity arterial disease in MASLD patients: a cross-sectional study Open
Higher FIB-4 levels are independently associated with the prevalence of LEAD in MASLD patients, although subgroup analyses did not reveal significant interactions. This suggests that further studies with larger sample sizes are needed to e…
View article: Obesity-driven oleoylcarnitine accumulation in tumor microenvironment promotes breast cancer metastasis-like phenotype
Obesity-driven oleoylcarnitine accumulation in tumor microenvironment promotes breast cancer metastasis-like phenotype Open
View article: Performance of Camellia oleifera Seedlings Under Alkali Stress Improved by Spraying with Types of Exogenous Biostimulants
Performance of Camellia oleifera Seedlings Under Alkali Stress Improved by Spraying with Types of Exogenous Biostimulants Open
Exogenous biostimulants (EB) are crucial for reducing abiotic stress in plants. It is currently unclear how EB such as melatonin (MT), betaine (BA), and salicylic acid (SA) regulate the stress in Camellia oleifera seedlings under alkali st…
View article: Kimi k1.5: Scaling Reinforcement Learning with LLMs
Kimi k1.5: Scaling Reinforcement Learning with LLMs Open
Language model pretraining with next token prediction has proved effective for scaling compute but is limited to the amount of available training data. Scaling reinforcement learning (RL) unlocks a new axis for the continued improvement of…
View article: Predicting the structures of cyclic peptides containing unnatural amino acids by HighFold2
Predicting the structures of cyclic peptides containing unnatural amino acids by HighFold2 Open
Cyclic peptides containing unnatural amino acids possess many excellent properties and have become promising candidates in drug discovery. Therefore, accurately predicting the three-dimensional structures of cyclic peptides containing unna…
View article: Exogenous riboflavin treatment delays yellowing in broccoli by inhibiting chlorophyll degradation and regulating endogenous phytohormones
Exogenous riboflavin treatment delays yellowing in broccoli by inhibiting chlorophyll degradation and regulating endogenous phytohormones Open
View article: Editorial: Chilling tolerance and regulation of horticultural crops: physiological, molecular, and genetic perspectives
Editorial: Chilling tolerance and regulation of horticultural crops: physiological, molecular, and genetic perspectives Open
View article: Organic Pollutant Fenton Degradation Driven by Self-activated Afterglow from Oxygen-vacancy-rich LiYScGeO<sub>4</sub>: Bi<sup>3+</sup> Long Afterglow Phosphor
Organic Pollutant Fenton Degradation Driven by Self-activated Afterglow from Oxygen-vacancy-rich LiYScGeO<sub>4</sub>: Bi<sup>3+</sup> Long Afterglow Phosphor Open
View article: Acetate-enabled staged strategy in Chlorella vulgaris culture: relieving ammonium inhibition while reducing ammonia stripping and enhancing protein content
Acetate-enabled staged strategy in Chlorella vulgaris culture: relieving ammonium inhibition while reducing ammonia stripping and enhancing protein content Open
View article: Optimal Tryptophan Improved Growth and Regulated Agonistic Behavior of Oriental River Prawn, <i>Macrobrachium nipponense</i>
Optimal Tryptophan Improved Growth and Regulated Agonistic Behavior of Oriental River Prawn, <i>Macrobrachium nipponense</i> Open
Tryptophan, recognized as the third limiting amino acid, plays a crucial physiological function. The optimal tryptophan requirement for oriental river prawn ( Macrobrachium nipponense ) was assessed, and its impact on agonistic behavior wa…
View article: Transcriptomics and Metabolomics Analysis Reveal the Differential Molecular Mechanisms of the 1-Mcp-Induced Fruit Disease Resistance of Korla Fragrant Pear
Transcriptomics and Metabolomics Analysis Reveal the Differential Molecular Mechanisms of the 1-Mcp-Induced Fruit Disease Resistance of Korla Fragrant Pear Open
View article: Intensified Seasonal Droughts and Carryover Effects Amplify Negative Growth Anomalies in Eurasian Grasslands During the Past Four Decades
Intensified Seasonal Droughts and Carryover Effects Amplify Negative Growth Anomalies in Eurasian Grasslands During the Past Four Decades Open
View article: Transcriptomics and Metabolomics Analysis Reveal the Differential Molecular Mechanisms of the 1-Mcp-Induced Fruit Disease Resistance of Korla Fragrant Pear
Transcriptomics and Metabolomics Analysis Reveal the Differential Molecular Mechanisms of the 1-Mcp-Induced Fruit Disease Resistance of Korla Fragrant Pear Open
View article: <scp>VOZ</scp>‐dependent priming of salicylic acid‐dependent defense against <i>Rhizopus stolonifer</i> by β‐aminobutyric acid requires the <scp>TCP</scp> protein <scp>TCP2</scp> in peach fruit
<span>VOZ</span>‐dependent priming of salicylic acid‐dependent defense against <i>Rhizopus stolonifer</i> by β‐aminobutyric acid requires the <span>TCP</span> protein <span>TCP2</span> in peach fruit Open
SUMMARY Vascular plant one‐zinc finger (VOZ) transcription factors (TFs) play crucial roles in plant immunity. Nevertheless, how VOZs modulate defense signaling in response to elicitor‐induced resistance is not fully understood. Here, the …
View article: EjWRKY6 Is Involved in the ABA-Induced Carotenoid Biosynthesis in Loquat Fruit during Ripening
EjWRKY6 Is Involved in the ABA-Induced Carotenoid Biosynthesis in Loquat Fruit during Ripening Open
The yellow-fleshed loquat is abundant in carotenoids, which determine the fruit’s color, provide vitamin A, and offer anti-inflammatory and anti-cancer health benefits. In this research, the impact of abscisic acid (ABA), a plant hormone, …
View article: Melatonin delayed senescence by modulating the contents of plant signalling molecules in postharvest okras
Melatonin delayed senescence by modulating the contents of plant signalling molecules in postharvest okras Open
Okra has been widely cultivated worldwide. Consumers appreciate its nutritional value and delicious taste. However, okra is very perishable after harvest because of rapid senescence and high susceptibility to mechanical injuries, which lim…