Shigeru Fujimura
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View article: Limitations of antimicrobial agent choice based on MIC value against Pseudomonas aeruginosa
Limitations of antimicrobial agent choice based on MIC value against Pseudomonas aeruginosa Open
Introduction. In antibiotic chemotherapy, an antimicrobial agent is selected based on MIC, which is determined by a test method using the principle of the broth microdilution. However, it does not provide a viable count in the mutant selec…
View article: Lactococcus lactis Strain Plasma Uniquely Induces IFN-α Production via Plasmacytoid Dendritic Cell Activation: A Comparative Study of Postbiotic Products
Lactococcus lactis Strain Plasma Uniquely Induces IFN-α Production via Plasmacytoid Dendritic Cell Activation: A Comparative Study of Postbiotic Products Open
Postbiotics are increasingly incorporated into functional foods and supplements due to their potential health benefits, particularly immune modulation. However, the mechanisms by which these products influence antiviral immunity remain inc…
View article: Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of Pseudomonas aeruginosa
Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of Pseudomonas aeruginosa Open
This study demonstrated that overexpression of the MexJK-OprM efflux pump is a key mechanism underlying TAZ/CTLZ resistance. In addition, prior administration of CAZ contributed to the acquisition of resistance, highlighting the need to co…
View article: The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation
The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation Open
Although the mutualistic relationship between the intestinal microbiota and the human host is crucial for maintaining health, the underlying mechanisms of this relationship remain unclear. In the present study, aiming to elucidate the regu…
View article: Impact of high-speed nanodroplets on various pathogenic bacterial cell walls
Impact of high-speed nanodroplets on various pathogenic bacterial cell walls Open
Although the development of disinfection technologies with novel mechanisms has stagnated, we demonstrate the bactericidal effects and mechanisms of high-speed nanodroplet generation technology. The first development of this technology in …
View article: The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis
The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis Open
In our findings, fluoroquinolone resistance was not observed in the E. coli strain after 5- to 10-days of exposure. However, resistance acquisition was detected frequently after 15- to 25-days of exposure. Among fluoroquinolones, lascuflox…
View article: The Optimization of Multi-objective FJSP Based on the Hybrid Algorithm
The Optimization of Multi-objective FJSP Based on the Hybrid Algorithm Open
The flexible job-shop scheduling problem (FJSP) is a critical model in manufacturing systems that assigns operations from different jobs to various machines. However, optimizing multiple targets during the production scheduling process is …
View article: Gated‐Attention Model with Reinforcement Learning for Solving Dynamic Job Shop Scheduling Problem
Gated‐Attention Model with Reinforcement Learning for Solving Dynamic Job Shop Scheduling Problem Open
Job shop scheduling problem (JSSP) is one of the well‐known NP‐hard combinatorial optimization problems (COPs) that aims to optimize the sequential assignment of finite machines to a set of jobs while adhering to specified problem constrai…
View article: Comparison of the efficacy and safety of standard‐ and high‐dose daptomycin: A systematic review and meta‐analysis
Comparison of the efficacy and safety of standard‐ and high‐dose daptomycin: A systematic review and meta‐analysis Open
Aims Standard doses of daptomycin at 4 and 6 mg/kg were used for the treatment of skin and soft tissue for infections and bacteraemia, respectively. However, increased doses of daptomycin are recommended for complicated infections by Gram‐…
View article: Cefmetazole Resistance Mechanism for Escherichia Coli Including ESBL-Producing Strains
Cefmetazole Resistance Mechanism for Escherichia Coli Including ESBL-Producing Strains Open
Our results showed that the mRNA expression levels of genes encoding porin were decreased in the strains that acquired resistance due to CMZ exposure, and that ompF and ompC in particular were thought to be involved in the acquisition of r…
View article: The Risk of Emerging Resistance to Trimethoprim/Sulfamethoxazole in Staphylococcus aureus
The Risk of Emerging Resistance to Trimethoprim/Sulfamethoxazole in Staphylococcus aureus Open
The emergent risk was SXT exposure of 14 days or more.
View article: Overproduction of Chromosomal <i>ampC</i> β-Lactamase Gene Maintains Resistance to Cefazolin in Escherichia coli Isolates
Overproduction of Chromosomal <i>ampC</i> β-Lactamase Gene Maintains Resistance to Cefazolin in Escherichia coli Isolates Open
This study is the first to demonstrate that mutations in the chromosomal- amp C attenuator region are responsible for the emergence of cefazolin resistance in Escherichia coli strains. The resistance was maintained even after culturing E. …
View article: Comparison of Pharmaceutical Characteristics between Brand-Name Meropenem and Its Generics
Comparison of Pharmaceutical Characteristics between Brand-Name Meropenem and Its Generics Open
This study aimed to provide comparative information of pharmaceutical properties, including particle morphology and distribution uniformity, solubility, presence of residual solvent and insoluble particles, and antimicrobial activities, be…
View article: Needlestick Injuries Among Healthcare Workers with COVID-19: A Questionnaire Survey
Needlestick Injuries Among Healthcare Workers with COVID-19: A Questionnaire Survey Open
2) ・三鴨 廣繁 2)
View article: Development of a Compact Plasma Sterilization Device for Contact Lenses
Development of a Compact Plasma Sterilization Device for Contact Lenses Open
In this study, our goal was to develop a contact lens sterilization device using non-thermal plasma. Three types of sterilization devices, a plasma-container-separated type (Ver. 1), a screw electrode type (Ver. 2), and a plasma actuator t…
View article: Optimization of bi-objective permutation flow shop scheduling with electricity cost consideration
Optimization of bi-objective permutation flow shop scheduling with electricity cost consideration Open
Increasing energy demand can create undesired problems for many governments worldwide. Several policies, such as time-of-use (TOU) tariffs, have been put in place to overcome such demand. The TOU policy’s objective is to reduce electrical …
View article: The updated JSPGHAN guidelines for the management of<i>Helicobacter pylori</i>infection in childhood
The updated JSPGHAN guidelines for the management of<i>Helicobacter pylori</i>infection in childhood Open
The Japan Pediatric Helicobacter pylori Study Group published the first guidelines on childhood H. pylori infection in 1997. They were later revised by the Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition (JSPGHAN)…
View article: Infection Control Standards Expected in the Primary Care Pharmacy
Infection Control Standards Expected in the Primary Care Pharmacy Open
In medical care, qualified physicians, nurses, and pharmacists have come to be recognized as a team integral to a patient's success, and this team approach to medical care has become popular. In the infectious disease field, more hospitals…
View article: Solving University Course Timetabling Problem Using Multi-Depth Genetic Algorithm
Solving University Course Timetabling Problem Using Multi-Depth Genetic Algorithm Open
The University Course Timetabling Problem (UCTP) is a scheduling problem of assigning teaching event in certain time and room by considering the constraints of university stakeholders such as students, lecturers, and departments. The const…
View article: Development of small closed-type sterilization device using atmospheric plasma
Development of small closed-type sterilization device using atmospheric plasma Open
In this study, we aimed to decrease emission of nitrogen oxide gases using intermittent discharges for a plasma sterilization device of contact lens. Although this device already has advantages such as low temperature, less emission of nit…
View article: Sterilization in liquids by air plasma under intermittent discharge
Sterilization in liquids by air plasma under intermittent discharge Open
In recent years, cold atmospheric plasma has received attention for medical applications like sterilization, injure treatment, and cancer cell treatment. Plasma sterilization is effective against a wide range of microorganisms. Plasma ster…
View article: Reinforced Island Model Genetic Algorithm to Solve University Course Timetabling
Reinforced Island Model Genetic Algorithm to Solve University Course Timetabling Open
The University Course Timetabling Problem (UCTP) is a scheduling problem of assigning teaching event in certain time and room by considering the constraints of university stakeholders such as students, lecturers, departments, etc. This pro…