Shigeru Kakuta
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View article: Loss of non-canonical translation initiation factors impairs perinatal cardiac function in mice
Loss of non-canonical translation initiation factors impairs perinatal cardiac function in mice Open
Translation regulation is crucial for cellular homeostasis. Recent studies have demonstrated that, in addition to the conventional AUG start codon, eukaryotic mRNA can also possess non-canonical start codons. These non-canonical start codo…
View article: Stingless bee propolis promotes hair follicle regeneration and melanocyte function in chemotherapy-induced alopecia mouse model
Stingless bee propolis promotes hair follicle regeneration and melanocyte function in chemotherapy-induced alopecia mouse model Open
Chemotherapy-induced alopecia (CIA) is one of the most apparent symptoms of side effects in a cancer patient undergoing chemotherapy using anti-cancer drugs, resulting in distress and a lower quality of life. Hence, this study investigated…
View article: Unveiling the Role of A2AR Dysregulation in Olfactory Dysfunction and Amyloidogenesis in Alzheimer’s Disease
Unveiling the Role of A2AR Dysregulation in Olfactory Dysfunction and Amyloidogenesis in Alzheimer’s Disease Open
Background Alzheimer’s Disease (AD) manifests early in the olfactory system, yet its precise role in the pathophysiology of AD remains elusive. This study aims to elucidate the progression of olfactory dysfunction in AD by investigating th…
View article: Establishment of the improved colonization of Escherichia coli laboratory strain in the intestine mediated by single gene deletion
Establishment of the improved colonization of Escherichia coli laboratory strain in the intestine mediated by single gene deletion Open
In light of the emerging importance of the gut microbiome in human health, there is a need to improve the colonization efficiency of therapeutic bacteria called probiotics. Despite their recognized potential, artificially administered bact…
View article: Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT
Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT Open
Background Transgenic (Tg) mice are widely used in biomedical research, and they are typically generated by injecting transgenic DNA cassettes into pronuclei of one-cell stage zygotes. Such animals often show unreliable expression of the t…
View article: Cardiolipin-Anticardiolipin Interaction with Functionalized Gold Nanoparticles for Immunological Reactions: An in Silico Approach
Cardiolipin-Anticardiolipin Interaction with Functionalized Gold Nanoparticles for Immunological Reactions: An in Silico Approach Open
View article: Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases
Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases Open
HSF (heat shock transcription factor or heat shock factor) was discovered as a transcription factor indispensable for heat shock response. Although four classical HSFs were discovered in mammals and two major HSFs, HSF1 and HSF2, were clon…
View article: The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway
The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway Open
Although hair loss is not a horrible disease, it sometimes reduces the patients' quality of life (QOL) and increases their mental stress. Currently, there is no effective treatment for hair loss. It is known that honeybee propolis has vari…
View article: Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance
Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance Open
View article: Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice
Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice Open
View article: Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models
Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models Open
Understanding the host anti-fungal immunity induced by beta-glucan has been one of the most challenging conundrums in the field of biomedical research. During the last couple of decades, insights on the role of beta-glucan in fungal diseas…
View article: A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease Open
View article: Pharmacology and Safety
Pharmacology and Safety Open
Propolis is a nature resinous mixture produced by honeybees that exhibit a wide range of biological functions.We previously reported that the propolis derived from Philippine endemic stingless bees (Tetragonula biroi, Friese) had anti-gast…
View article: LAS Seminar 3
LAS Seminar 3 Open
The pandemic of new coronavirus "SARS-CoV-2" led the Japanese government to declare a state of emergency, and universities were also required to take strong measures against the infectious disease as organizational efforts.In the Universit…
View article: Suppression of tensin 2 promotes intestinal tumorigenesis by liberating integrin-linked kinase-induced nuclear translocation of β-catenin
Suppression of tensin 2 promotes intestinal tumorigenesis by liberating integrin-linked kinase-induced nuclear translocation of β-catenin Open
Tensin 2 (TNS2) is a focal adhesion-localized multidomain protein expressed in various tissues. TNS2 expression significantly decreases in many tumor cell lines, and low TNS2 expression is associated with a poorer relapse-free survival in …
View article: Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma
Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma Open
The protective property of propolis across a wide spectrum of diseases has long been realized, yet the anti-tumor efficacy of this bioactive substance from Philippine stingless bees has remained poorly understood. Here, we showed the tumor…
View article: Analysis of <i>A4gnt</i> Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda
Analysis of <i>A4gnt</i> Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda Open
Gastric adenocarcinoma cells secrete sulfomucins, but their role in gastric tumorigenesis remains unclear. To address that question, we generated A4gnt/ Chst4 double-knockout (DKO) mice by crossing A4gnt knockout (KO) mice, which spontaneo…
View article: Young Scientist Award
Young Scientist Award Open
Primate embryonic stem cells (ESCs) represent a later developmental stage and resemble the postimplantation epiblast, in contrast to mouse ESCs, which share defining features with the pre-implantation epiblast.Mouse ESCs give rise to chime…
View article: Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation
Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation Open
View article: Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis
Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis Open
Herpes simplex virus-1 (HSV-1) is the most common cause of sporadic viral encephalitis, which can be lethal or result in severe neurological defects even with antiviral therapy. While HSV-1 causes encephalitis in spite of HSV-1-specific hu…
View article: Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses
Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses Open
View article: Adenocarcinoma of Barrett’s esophagus in a dog
Adenocarcinoma of Barrett’s esophagus in a dog Open
An endoscopic examination revealed a mass in the distal esophagus of a 9-year-old intact male bulldog. Histopathologically, the mass was composed of cuboidal to columnar neoplastic epithelial cells and extended from the squamous epithelium…
View article: Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo
Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo Open
Probiotics, such as lactic acid bacteria (LAB) and Bacillus subtilis var. natto, have been shown to modulate immune responses. It is important to understand how probiotic bacteria impact intestinal epithelial cells (IECs), be…
View article: Zygote-mediated generation of genome-modified mice using Streptococcus thermophilus 1-derived CRISPR/Cas system
Zygote-mediated generation of genome-modified mice using Streptococcus thermophilus 1-derived CRISPR/Cas system Open
Mammalian zygote-mediated genome-engineering by CRISPR/Cas is currently used for the generation of genome-modified animals. Here we report that a Streptococcus thermophilus-1 derived orthologous CRISPR/Cas system, which recognizes the 5'-N…
View article: The potential for repositioning antithyroid agents as antiasthma drugs
The potential for repositioning antithyroid agents as antiasthma drugs Open
View article: CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis
CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis Open
View article: Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine
Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine Open
View article: IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells
IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells Open
Interleukin-17 (IL-17)-producing γδ T (γδ17) cells have been implicated in inflammatory diseases, but the underlying pathogenic mechanisms remain unclear. Here, we show that both CD4 + and γδ17 cells are required for the development of aut…