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View article: The RANK/RANKL axis controls vascular dynamics in the bone marrow
The RANK/RANKL axis controls vascular dynamics in the bone marrow Open
Receptor activator of nuclear factor kappa B ligand (RANKL) is an essential cytokine that induces osteoclastic differentiation by monocyte-macrophage lineage precursors. Here, we showed that in addition to its conventional action, RANKL co…
View article: High HER2 Intratumoral Heterogeneity Is Resistant to Anti-HER2 Neoadjuvant Chemotherapy in Early Stage and Locally Advanced HER2-Positive Breast Cancer
High HER2 Intratumoral Heterogeneity Is Resistant to Anti-HER2 Neoadjuvant Chemotherapy in Early Stage and Locally Advanced HER2-Positive Breast Cancer Open
Background/Objectives: Breast cancer tumors possess intratumoral heterogeneity (ITH), which is associated with therapeutic resistance. Tumors with high ITH exhibit human epidermal growth factor receptor 2 (HER2) heterogeneity, affecting th…
View article: Learning from Similarity Proportion Loss for Classifying Skeletal Muscle Recovery Stages
Learning from Similarity Proportion Loss for Classifying Skeletal Muscle Recovery Stages Open
Evaluating the regeneration process of damaged muscle tissue is a fundamental analysis in muscle research to measure experimental effect sizes and uncover mechanisms behind muscle weakness due to aging and disease. The conventional approac…
View article: The superior colliculus arbitrates whole-brain dynamics for unconscious visual insight
The superior colliculus arbitrates whole-brain dynamics for unconscious visual insight Open
The human capacity for sudden insight, often marked by abrupt and illuminating “eureka” moments, has long intrigued neuroscientists seeking to understand its elusive neural basis 1–6 . Mooney image recognition offers a compelling behaviora…
View article: IRSN-23 gene diagnosis enhances breast cancer subtype classification and predicts response to neoadjuvant chemotherapy: new validation analyses
IRSN-23 gene diagnosis enhances breast cancer subtype classification and predicts response to neoadjuvant chemotherapy: new validation analyses Open
Background This study evaluates the reproducibility of the IRSN-23 model, which classifies patients into highly chemotherapy-sensitive (Gp-R) or less-sensitive (Gp-NR) groups based on immune-related gene expression using DNA microarray ana…
View article: P035: Establishment of Newly Rapid and Accurate Intra-operative Examination of the Surgical Margin Status in Breast-Conserving Surgery by “Click-to-sense” Assay
P035: Establishment of Newly Rapid and Accurate Intra-operative Examination of the Surgical Margin Status in Breast-Conserving Surgery by “Click-to-sense” Assay Open
View article: A Novel Classification of Critical Illness Based on Whole Blood Transcriptome
A Novel Classification of Critical Illness Based on Whole Blood Transcriptome Open
View article: Exploration of Key Signals in Alopecia Areata by Cell-Cell Interaction Analysis
Exploration of Key Signals in Alopecia Areata by Cell-Cell Interaction Analysis Open
Alopecia Areata (AA) is an autoimmune disease resulting from a breach in the immune privilege of the hair follicles. To gain insights into the mechanism, we focused on the interactions between cells in the hair follicles. Dermal Papilla (D…
View article: Novel integrated multiomics analysis reveals a key role for integrin beta-like 1 in wound scarring
Novel integrated multiomics analysis reveals a key role for integrin beta-like 1 in wound scarring Open
Exacerbation of scarring can originate from a minority fibroblast population that has undergone inflammatory-mediated genetic changes within the wound microenvironment. The fundamental relationship between molecular and spatial organizatio…
View article: Communication Analysis between Human Hair-Follicles and Immune Cells with Single-cell RNA-seq
Communication Analysis between Human Hair-Follicles and Immune Cells with Single-cell RNA-seq Open
View article: Quantifying the recovery process of skeletal muscle on hematoxylin and eosin stained images via learning from label proportion
Quantifying the recovery process of skeletal muscle on hematoxylin and eosin stained images via learning from label proportion Open
View article: IRSN-23 Gene Diagnosis Predicts Response to Neoadjuvant Chemotherapy and Refines Breast Cancer Subtype Classification (Prospective Analyses)
IRSN-23 Gene Diagnosis Predicts Response to Neoadjuvant Chemotherapy and Refines Breast Cancer Subtype Classification (Prospective Analyses) Open
Introduction: This study evaluates the reproducibility of the IRSN-23 model, which classifies patients into highly chemotherapy-sensitive (Gp-R) or less-sensitive (Gp-NR) groups based on immune-related gene expression using DNA microarray …
View article: MyoRegenTrack: Quantifying the Recovery Process of Skeletal Muscle on HE-Stained Images via Learning from Label Proportion
MyoRegenTrack: Quantifying the Recovery Process of Skeletal Muscle on HE-Stained Images via Learning from Label Proportion Open
Visual observing muscle tissue regeneration is used to measure experimental effect size in biological research to discover the mechanism of muscle strength decline due to illness or aging. Quantitative computer imaging analysis for support…
View article: A single fast Hebbian-like process enabling one-shot class addition in deep neural networks without backbone modification
A single fast Hebbian-like process enabling one-shot class addition in deep neural networks without backbone modification Open
One-shot learning, the ability to learn a new concept from a single instance, is a distinctive brain function that has garnered substantial interest in machine learning. While modeling physiological mechanisms poses challenges, advancement…
View article: Plasma proteomics profile-based comparison of torso versus brain injury: A prospective cohort study
Plasma proteomics profile-based comparison of torso versus brain injury: A prospective cohort study Open
BACKGROUND Trauma-related deaths and posttraumatic sequelae are a global health concern, necessitating a deeper understanding of the pathophysiology to advance trauma therapy. Proteomics offers insights into identifying and analyzing plasm…
View article: Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells
Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells Open
Skeletal muscles exert remarkable regenerative or adaptive capacities in response to injuries or mechanical loads. However, the cellular networks underlying muscle adaptation are poorly understood compared to those underlying muscle regene…
View article: Association between tranexamic acid administration and mortality based on the trauma phenotype: a retrospective analysis of a nationwide trauma registry in Japan
Association between tranexamic acid administration and mortality based on the trauma phenotype: a retrospective analysis of a nationwide trauma registry in Japan Open
View article: High HER2 Intratumoral Heterogeneity Is a Predictive Factor for Poor Prognosis in Early-Stage and Locally Advanced HER2-Positive Breast Cancer
High HER2 Intratumoral Heterogeneity Is a Predictive Factor for Poor Prognosis in Early-Stage and Locally Advanced HER2-Positive Breast Cancer Open
Purpose: Breast cancer tumors frequently have intratumoral heterogeneity (ITH). Tumors with high ITH cause therapeutic resistance and have human epidermal growth factor receptor 2 (HER2) heterogeneity in response to HER2-targeted therapies…
View article: High HER2 intratumoral heterogeneity is a predictive factor for poor prognosis in Early-stage and Locally Advanced HER2-positive Breast Cancer
High HER2 intratumoral heterogeneity is a predictive factor for poor prognosis in Early-stage and Locally Advanced HER2-positive Breast Cancer Open
PURPOSE: Breast cancer tumors frequently have intratumor heterogeneity. Tumors with high intratumor heterogeneity have caused therapeutic resistance and have human epidermal growth factor receptor 2 (HER2) heterogeneity in response to HER2…
View article: A Novel Approach to Detection Algorithms for Artifacts in Clinical Endoscopy
A Novel Approach to Detection Algorithms for Artifacts in Clinical Endoscopy Open
View article: Biodiversity and Constrained Information Dynamics in Ecosystems: A Framework for Living Systems
Biodiversity and Constrained Information Dynamics in Ecosystems: A Framework for Living Systems Open
The increase in ecosystem biodiversity can be perceived as one of the universal processes converting energy into information across a wide range of living systems. This study delves into the dynamics of living systems, highlighting the dis…
View article: Biodiversity and Constrained Information Dynamics in Ecosystems: A Framework for Living Systems
Biodiversity and Constrained Information Dynamics in Ecosystems: A Framework for Living Systems Open
The increase in ecosystem biodiversity can be perceived as one of the universal processes converting energy into information across a wide range of living systems. This study delves into the dynamics of living systems, highlighting the dis…
View article: Prospective validation of the IRSN-23 model for personalized chemotherapy and proposal of new breast cancer subtype classification.
Prospective validation of the IRSN-23 model for personalized chemotherapy and proposal of new breast cancer subtype classification. Open
10 Background: The IRSN-23 model uses DNA microarray analysis of tumor tissue to stratify patients into highly sensitive (Gp-R) or less sensitive (Gp-NR) chemotherapy groups based on immune-related gene expression. In a previous report (n=…
View article: Cell Tracking via Reinforcement Learning with Microscopic Image Simulator
Cell Tracking via Reinforcement Learning with Microscopic Image Simulator Open
Recent advances in optical microscopy and fluorescent protein technology have made it possible to record movies of cells over time while keeping them alive. Cell tracking is necessary to extract and analyze cell dynamics from these movies.…
View article: A Cell Tracking Method for Dynamic Analysis of Immune Cells Based on Deep Learning
A Cell Tracking Method for Dynamic Analysis of Immune Cells Based on Deep Learning Open
Since the dynamics of immune cells change about phenomena in a living body, it is very important to observe and analyze cell dynamics in vivo in real-time.For this purpose, it is necessary to extract the information for the analysis by acc…
View article: Simulating Reaction Time for Eureka Effect in Visual Object Recognition Using Artificial Neural Network
Simulating Reaction Time for Eureka Effect in Visual Object Recognition Using Artificial Neural Network Open
The human brain can recognize objects hidden in even severely degraded images after observing them for a while, which is known as a type of Eureka effect, possibly associated with human creativity. A previous psychological study suggests t…
View article: Regulation of Muscle Hypertrophy Through Granulin: Interplay of Mesenchymal Progenitors, Macrophages, and Muscle Satellite Cells
Regulation of Muscle Hypertrophy Through Granulin: Interplay of Mesenchymal Progenitors, Macrophages, and Muscle Satellite Cells Open
View article: Identification of a unique subset of tissue-resident memory CD4 <sup>+</sup> T cells in Crohn’s disease
Identification of a unique subset of tissue-resident memory CD4 <sup>+</sup> T cells in Crohn’s disease Open
T cells differentiate into highly diverse subsets and display plasticity depending on the environment. Although lymphocytes are key mediators of inflammation, functional specialization of T cells in inflammatory bowel disease (IBD) has not…
View article: Combination of WFDC2, CHI3L1, and KRT19 in Plasma Defines a Clinically Useful Molecular Phenotype Associated with Prognosis in Critically Ill COVID-19 Patients
Combination of WFDC2, CHI3L1, and KRT19 in Plasma Defines a Clinically Useful Molecular Phenotype Associated with Prognosis in Critically Ill COVID-19 Patients Open
View article: Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling
Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling Open
Runt-related transcription factor 2 (Runx2), a regulator of osteoblast differentiation, is pathologically involved in vascular calcification; however, the significance of Runx2 in cardiac homeostasis remains unclear. Here, we investigated …