Explanipedia

Clinical and MR findings of pediatric medulloblastoma extending through the fourth ventricular outlets versus anaplastic ependymoma Open

Hsin‐Wei Wu, Chia‐Hung Wu, Shih‐Chieh Lin, Chih‐Chun Wu, Hsin‐Hung Chen , et al. · 2025

PurposeMedulloblastoma and anaplastic ependymoma (AE) are common malignant pediatric posterior fossa tumors with differing outcomes. While tumor extension through the fourth ventricular outlets (TETFVO) is common in AEs, it also occurs in …

Night-shift work and its association with metabolic syndrome Open

Shih‐Chieh Lin, Wei-Chung Yeh, Zhong-Yue Liu, H.K. Hsü, Jau‐Yuan Chen · 2025

This study explores the correlation between metabolic syndrome and night-shift work in Taiwan by analyzing employees’ annual health check data (March 2019). More than 9000 records were enrolled. Through the analysis of the annual health ch…

Recurrent meningioma treated with boron neutron capture therapy: a feasibility study with dosimetric and clinical correlates Open

Tien‐Li Lan, Chun‐Fu Lin, Yi‐Yen Lee, Feng‐Chi Chang, Shih‐Chieh Lin , et al. · 2025

Background Boron neutron capture therapy (BNCT) is a targeted radiotherapy modality that has shown promise in the treatment of recurrent gliomas and head and neck cancers. Although meningiomas are generally slow-growing, recent studies hav…

Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study Open

Kwok Wai Lo, Kuo‐Hung Huang, Wen-Liang Fang, Shih‐Chieh Lin, Yi‐Ping Hung , et al. · 2025

Background Lymph node dissection is a standardized procedure in gastric cancer surgery. Typically, lymph node metastasis begins in the perigastric (PG) region and then extends to the extraperigastric (EP) region. However, in some circumsta…

First Application of Boron Neutron Capture Therapy for Recurrent Clival Chordoma With Brainstem Abutment Open

Hong Liao, Tien‐Li Lan, Chun‐Fu Lin, Yi‐Yen Lee, Ko-Han Lin , et al. · 2025

Bevacizumab alternating chemotherapy for improving the survival of patients with recurrent high-grade glioma Open

Ping-Chuan Liu, Chao-Yang Kuo, Yiwei Chen, Chun‐Fu Lin, Shih‐Chieh Lin , et al. · 2025

Background High-grade glioma (HGG) is an aggressive tumor for which there are no effective therapies at recurrence, especially for isocitrate dehydrogenase (IDH)-wild-type glioblastoma. This retrospective study compared survival outcomes b…

Carboplatin and vinblastine monthly in the optic pathway and hypothalamic gliomas: A retrospective analysis in a single institute Open

T. P. Lin, Chao-Yang Kuo, Feng Chang, Shih‐Chieh Lin, Yi‐Wei Chen , et al. · 2025

Background Chemotherapy plays an important role in the treatment of optic pathway hypothalamic gliomas (OPHGs). Commonly used regimens include carboplatin and vincristine and monotherapy with vinblastine weekly. In this retrospective study…

A comparison of the clinicopathological features and genetic alterations in stage II/III gastric cancer with no recurrence, early recurrence and late recurrence after curative surgery Open

Yun-Ning Chiu, Ching-Yun Kung, Kuo‐Hung Huang, Shih‐Chieh Lin, Wen‐Liang Fang , et al. · 2024

Background: Few studies have explored the genetic changes and clinicopathological features of stage II/III gastric cancer (GC) patients with no tumor recurrence, early recurrence, or late recurrence after curative surgery. Methods: In this…

Tumefactive Demyelination Lesions: Report on Three Cases Open

Chi-Ju Lin, Shih‐Chieh Lin, Kai‐Wei Yu, Wen-Yu Ou Yang, Yi‐Chung Lee , et al. · 2024

Purpose: Tumefactive demyelination (TD) lesion and its subtype Balo’s concentric sclerosis (BCS), are rare manifestations of central nervous system demyelinating disease. Because of its rarity, physicians might hesitate in reaching a diagn…

A brief summary of the WHO 2021 classification of adult diffuse gliomas Open

Tien‐Li Lan, Shih‐Chieh Lin, Yi‐Wei Chen, Yi‐Yen Lee · 2024

The World Health Organization (WHO) classification system for central nervous system (CNS) tumors provides a distinct framework for differentiating these tumors from other types. Notably, gliomas are the most common and clinically signific…

Clinicopathologic Features and Prognosis of HER2-Positive Gastric Cancer Open

Ching-Yun Kung, Kuo‐Hung Huang, Shih‐Chieh Lin, Yi‐Ping Hung, Ming‐Huang Chen , et al. · 2024

Background The role of human epidermal growth factor receptor 2 (HER2) overexpression has been well established in breast cancer, with corresponding targeted therapies. In contrast, the clinicopathologic features and prognosis of HER2 over…

The behavioral signature of stepwise learning strategy in male rats and its neural correlate in the basal forebrain Open

Hachi E. Manzur, Ksenia Vlasov, You-Jhe Jhong, Hung-Yen Chen, Shih‐Chieh Lin · 2023

Studies of associative learning have commonly focused on how rewarding outcomes are predicted by either sensory stimuli or animals’ actions. However, in many learning scenarios, reward delivery requires the occurrence of both sensory stimu…

Figure S5 from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Open

Pei‐Chi Hou, Yo-Hua Li, Shih‐Chieh Lin, Shau-Chieh Lin, Jenq‐Chang Lee , et al. · 2023

Knockdown of DUSP2 facilitates xenograft tumor growth

Figure S7 from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Open

Pei‐Chi Hou, Yo-Hua Li, Shih‐Chieh Lin, Shau-Chieh Lin, Jenq‐Chang Lee , et al. · 2023

HDACi inhibits tumor growth and drug resistance

Figure S2 from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Open

Pei‐Chi Hou, Yo-Hua Li, Shih‐Chieh Lin, Shau-Chieh Lin, Jenq‐Chang Lee , et al. · 2023

Knockdown of DUSP2 enhanced EMT process and migration/invasion ability

Supplementary Table 1, Figures 1-8 from Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer Open

Chun‐Wei Chien, Shih‐Chieh Lin, Yen‐Yu Lai, Bo-Wen Lin, Shao-Chieh Lin , et al. · 2023

PDF file - 477K

Figures S3-S4 from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Open

Pei‐Chi Hou, Yo-Hua Li, Shih‐Chieh Lin, Shau-Chieh Lin, Jenq‐Chang Lee , et al. · 2023

Figure S3: PGE2 mediates loss-of-DUSP2-induced cancer stemness. Figure S4: Hypoxia-induced COX-2 expression is mediated by downregulation of DUSP2.

Figure S1 from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Open

Pei‐Chi Hou, Yo-Hua Li, Shih‐Chieh Lin, Shau-Chieh Lin, Jenq‐Chang Lee , et al. · 2023

Loss-of-DUSP2 results in the expansion of CSC-like population.

Supplementary Table 1, Figures 1-8 from Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer Open

Chun‐Wei Chien, Shih‐Chieh Lin, Yen‐Yu Lai, Bo-Wen Lin, Shao-Chieh Lin , et al. · 2023

PDF file - 477K

Figure S6 from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Open

Pei‐Chi Hou, Yo-Hua Li, Shih‐Chieh Lin, Shau-Chieh Lin, Jenq‐Chang Lee , et al. · 2023

HDACi abolished hypoxia-induced cancer malignancy

Data from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Open

Pei‐Chi Hou, Yo-Hua Li, Shih‐Chieh Lin, Shau-Chieh Lin, Jenq‐Chang Lee , et al. · 2023

Cancer stem-like cells (CSC) evolve to overcome the pressures of reduced oxygen, nutrients or chemically induced cell death, but the mechanisms driving this evolution are incompletely understood. Here, we report that hypoxia-mediated downr…

CCR Translation on the Article from Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer Open

Chun‐Wei Chien, Shih‐Chieh Lin, Yen‐Yu Lai, Bo-Wen Lin, Shao-Chieh Lin , et al. · 2023

CCR Translation on the Article from Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer

Data from Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer Open

Chun‐Wei Chien, Shih‐Chieh Lin, Yen‐Yu Lai, Bo‐Wen Lin, Shao-Chieh Lin , et al. · 2023

Purpose: The first step of metastasis is the detachment of cancer cells from the surrounding matrix and neighboring cells; however, how cancer cells accomplish this process remains unclear. Thus, we aimed to investigate the underlyi…

Supplementary figure legend from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Open

Pei‐Chi Hou, Yo-Hua Li, Shih‐Chieh Lin, Shau-Chieh Lin, Jenq‐Chang Lee , et al. · 2023

Legends for supplementary figures S1-S7