Shih-Ching Chou
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View article: Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin
Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin Open
Physical activity provides clinical benefit in Parkinson’s disease (PD). Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show tha…
View article: Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease Open
View article: PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease
PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease Open
View article: Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein Open
α-synuclein (α-syn) aggregation and accumulation drive neurodegeneration in Parkinson's disease (PD). The substantia nigra of patients with PD contains excess iron, yet the underlying mechanism accounting for this iron accumulation is uncl…
View article: Recent advances in preventing neurodegenerative diseases
Recent advances in preventing neurodegenerative diseases Open
The worldwide health-care burden of neurodegenerative diseases is on the rise-a crisis created through a combination of increased caseload and lack of effective treatments. The limitations of pharmacotherapy in these disorders have led to …