Yu Lan
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View article: Key Technologies and Research Prospects for Defense Strategies Against Cyberattacks in Electricity Markets
Key Technologies and Research Prospects for Defense Strategies Against Cyberattacks in Electricity Markets Open
The deep integration of digital technologies has significantly improved the operational efficiency of electricity markets, but it has also introduced increasingly severe and sophisticated cybersecurity challenges. As a highly coupled cyber…
View article: Theoretical Study on the Inhibition Mechanism of the Proteasome by Bortezomib
Theoretical Study on the Inhibition Mechanism of the Proteasome by Bortezomib Open
Bortezomib can form covalent bonds with the proteasome to kill myeloma tumor cell, but the detailed covalent inhibition reaction mechanism remains unclear. In this study, we first established the parameters for boron atom in bortezomib and…
View article: Tobacco rattle virus infection alters Arabidopsis gene expression via virus-derived SiRNAs and host MiRNA network disruption
Tobacco rattle virus infection alters Arabidopsis gene expression via virus-derived SiRNAs and host MiRNA network disruption Open
Background Virus-induced gene silencing (VIGS) technology based on tobacco rattle virus (TRV) has been widely employed in plant gene function research. However, the regulatory roles of TRV-derived small interfering RNAs (siRNAs) in Arabido…
View article: The Origin of Stereoselectivity in Dual Transition‐Metal/NHC Asymmetric Catalysis: A Competitive Induction Model
The Origin of Stereoselectivity in Dual Transition‐Metal/NHC Asymmetric Catalysis: A Competitive Induction Model Open
Comprehensive Summary The origin of a transformation's stereoselectivity is one of the core issues in asymmetric catalysis. Herein, we propose a general competitive induction model for predicting stereoselectivity in dual transition‐metal‐…
View article: Structural, Physiological, and Biochemical Responses of Oreorchis patens (Lindl.) Leaves Under Cold Stress
Structural, Physiological, and Biochemical Responses of Oreorchis patens (Lindl.) Leaves Under Cold Stress Open
Cold stress significantly impairs plant growth and development, making the study of cold resistance mechanisms a critical research focus. Oreorchis patens (Lindl.) exhibits strong cold hardiness, yet its molecular and physiological adaptat…
View article: The Application and Safety of Novel Additives in Artificial Meat
The Application and Safety of Novel Additives in Artificial Meat Open
As an emerging food, artificial meat is gradually taking over the catering market. The application and safety of its new additives in food have drawn much attention. The application demand for new additives in both plant-based meat and cel…
View article: Practical access to axially chiral triazole phosphine oxides via enantioselective CuAAC reaction
Practical access to axially chiral triazole phosphine oxides via enantioselective CuAAC reaction Open
View article: Enhanced One‐Pot Cas12a‐Based Nucleic Acid Detection via Epitope Insertion and Recruitment of Rad51
Enhanced One‐Pot Cas12a‐Based Nucleic Acid Detection via Epitope Insertion and Recruitment of Rad51 Open
The CRISPR‐Cas12a system has emerged as a promising tool for nucleic acid‐based diagnostics. However, its multi‐step workflow and limited sensitivity hinder its integration into point‐of‐care testing (POCT). Here, the ECOT system (Engineer…
View article: Enantioselective construction of cyclic quaternary stereocenters via dinuclear copper catalyzed asymmetric [3 + 2] propargylation/annulation
Enantioselective construction of cyclic quaternary stereocenters via dinuclear copper catalyzed asymmetric [3 + 2] propargylation/annulation Open
View article: xDeepServe: Model-as-a-Service on Huawei CloudMatrix384
xDeepServe: Model-as-a-Service on Huawei CloudMatrix384 Open
The rise of scaled-out LLMs and scaled-up SuperPods signals a new era in large-scale AI infrastructure. LLMs continue to scale out via MoE, as seen in recent models like DeepSeek, Kimi, and Qwen. In parallel, AI hardware is scaling up, wit…
View article: Organocatalytic kinetic resolution of sulfinamides by N/O exchange
Organocatalytic kinetic resolution of sulfinamides by N/O exchange Open
Kinetic resolution is a promising strategy for accessing enantioenriched molecules from racemic mixtures. However, this method has not previously been realized in the synthesis of chiral sulfinyl scaffolds via S(IV)-X bond exchange. We dis…
View article: Design, synthesis and biological evaluation of novel urolithin derivatives targeting liver cancer cells
Design, synthesis and biological evaluation of novel urolithin derivatives targeting liver cancer cells Open
We designed and synthesised 22 new urolithin derivatives (UDs) based on methyl-urolithin A (mUA) to identify anti-cancer drugs with high efficacy and low toxicity and evaluated their anti-cancer activities in vitro. Cytotoxicity tes…
View article: Renewable Photosensitive Castor Oil to Fabricate Ionogels: Freezing‐Tolerance, Stretchability, and Degradation for 3D Printing and Flexible Sensor Applications
Renewable Photosensitive Castor Oil to Fabricate Ionogels: Freezing‐Tolerance, Stretchability, and Degradation for 3D Printing and Flexible Sensor Applications Open
With the escalating demands for sustainability in flexible sensing materials, the development of a novel, environmentally friendly, and multifunctional ionogel utilizing bio‐based raw materials has become paramount. However, castor oil wit…
View article: Synthesis of benzoheterocycles by palladium-catalyzed migratory cyclization through an unexpected reaction cascade
Synthesis of benzoheterocycles by palladium-catalyzed migratory cyclization through an unexpected reaction cascade Open
Migratory functionalization of C-H bonds through metal migration from carbon to carbon under transition metal catalysis is a process of significant academic and industrial interest. Herein, a palladium-catalyzed migratory cyclization of α-…
View article: Identification of the co-regulatory siRNAs of “miRNA→target” in Oryza sativa
Identification of the co-regulatory siRNAs of “miRNA→target” in Oryza sativa Open
The current “small interfering RNA(siRNA)→Target” mining tools can only search for targets of known siRNAs, and cannot discover co-regulatory siRNAs of unknown sequences that may exist, which means that the “microRNA(miRNA)→Target” databas…
View article: Regulation of the Thermoelectric Properties of Perovskite RECoO3 Ceramics via High-Entropy Engineering
Regulation of the Thermoelectric Properties of Perovskite RECoO3 Ceramics via High-Entropy Engineering Open
Entropy engineering has been demonstrated to be an effective strategy to regulate the thermoelectric properties of materials. In this work, we report a series of single-phase cubic (La0.25Sr0.25Ba0.25Ca0.25)CoO3 (LSBC), (La0.25Nd0.25Sr0.25…
View article: Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules
Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules Open
View article: Mybl2 Enhances Salt Tolerance Via Bes1-Mybl2-Tpr3 Protein Complex
Mybl2 Enhances Salt Tolerance Via Bes1-Mybl2-Tpr3 Protein Complex Open
View article: Mybl2 Enhances Salt Tolerance Via Bes1-Mybl2-Tpr3 Protein Complex
Mybl2 Enhances Salt Tolerance Via Bes1-Mybl2-Tpr3 Protein Complex Open
View article: The Significance of Achieving Carbon Peak and Carbon Neutrality Goals in the Gansu Section of the Yellow River Basin from the Perspective of High-quality Development
The Significance of Achieving Carbon Peak and Carbon Neutrality Goals in the Gansu Section of the Yellow River Basin from the Perspective of High-quality Development Open
The high-quality development of the Yellow River Basin and the strategies of peaking carbon dioxide emissions and achieving carbon neutrality are of great significance to the great rejuvenation of the Chinese nation and the sustainable dev…
View article: Noncanonical Electron Donor-Acceptor Model: Photoinduced Charge Transfer Between Metal-Based Photocatalyst and Inorganic Base
Noncanonical Electron Donor-Acceptor Model: Photoinduced Charge Transfer Between Metal-Based Photocatalyst and Inorganic Base Open
The fundamental transitions of metal-based photocatalysts from ground to excited states are typically metal-to-ligand or ligand-to-metal charge transfer, which require high-energy visible-light absorption. Herein, we describe a noncanonica…
View article: Relay-Hydrogen Atom Transfer Mode for Nickel-Hydride-Mediated <i>anti</i> -Markovnikov Hydroalkylation of Alkenes
Relay-Hydrogen Atom Transfer Mode for Nickel-Hydride-Mediated <i>anti</i> -Markovnikov Hydroalkylation of Alkenes Open
View article: Nickel‐Catalyzed Atroposelective Carbo‐Carboxylation of Alkynes with CO<sub>2</sub>: En Route to Axially Chiral Carboxylic Acids
Nickel‐Catalyzed Atroposelective Carbo‐Carboxylation of Alkynes with CO<sub>2</sub>: En Route to Axially Chiral Carboxylic Acids Open
Precise synthesis of carboxylic acids via catalytic carboxylation with CO 2 is highly appealing. Although considerable advancements have been achieved in difunctionalizing carboxylation of unsaturated hydrocarbons, the asymmetric variants …
View article: Theoretical study on ligand conformational self-adaptation for modulating reactivity
Theoretical study on ligand conformational self-adaptation for modulating reactivity Open
View article: Bifunctional iron-catalyzed alkyne Z-selective hydroalkylation and tandem Z-E inversion via radical molding and flipping
Bifunctional iron-catalyzed alkyne Z-selective hydroalkylation and tandem Z-E inversion via radical molding and flipping Open
View article: Enantioselective de novo construction of 3‑oxindoles via organocatalyzed formal [3 + 2] annulation from simple arylamines
Enantioselective de novo construction of 3‑oxindoles via organocatalyzed formal [3 + 2] annulation from simple arylamines Open
The de novo construction of enantioenriched 3-hydroxyindolenines and 3-oxindoles from easily available starting materials has been highly desired. Herein, an enantioselectively intermolecular direct [3 + 2] annulation of aryl amine with 2,…
View article: Iron photocatalysis via Brønsted acid-unlocked ligand-to-metal charge transfer
Iron photocatalysis via Brønsted acid-unlocked ligand-to-metal charge transfer Open
View article: Photochemical Asymmetric Palladium-Catalyzed Allylation Reaction: Expeditious Entry to Chiral 1,2-Amino Alcohols and 1,2-Diamines
Photochemical Asymmetric Palladium-Catalyzed Allylation Reaction: Expeditious Entry to Chiral 1,2-Amino Alcohols and 1,2-Diamines Open
The construction of diverse alkylamines is of importance in drug discovery and natural product synthesis. Herein, we report an efficient photoredox/palladium dual catalysis for the construction of protected 1,2-amino alcohols and 1,2-diami…
View article: Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions
Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions Open
View article: Asymmetric Csp3-Csp3 Bond Formation via Ni-Catalyzed Regio- and Enantioselective Hydroalkylation of 1,3-Diene through Carbonyl Umpolung
Asymmetric Csp3-Csp3 Bond Formation via Ni-Catalyzed Regio- and Enantioselective Hydroalkylation of 1,3-Diene through Carbonyl Umpolung Open
The asymmetric Csp3-Csp3 bond formation has been a grand pursuit in synthetic chemistry. The regio- and enantionselective hydroalkylation of 1,3-diene has emerged as an appealing approach for constructing chiral allylic Csp3-Csp3 bonds. Ho…