Shih‐Hung Yang
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View article: Age-stratified analysis of the outcomes of craniotomy versus minimally invasive surgery in patients with spontaneous intracerebral hemorrhage
Age-stratified analysis of the outcomes of craniotomy versus minimally invasive surgery in patients with spontaneous intracerebral hemorrhage Open
Hemorrhagic stroke carries high risks of mortality and morbidity. Age is a crucial factor that influences recovery. MIS yields favorable outcomes and should be prioritized for spontaneous ICH, particularly older patients.
View article: Improved survival with adding-on strategy after failure of nanoliposomal irinotecan plus 5-fluorouracil and leucovorin in metastatic pancreatic adenocarcinoma
Improved survival with adding-on strategy after failure of nanoliposomal irinotecan plus 5-fluorouracil and leucovorin in metastatic pancreatic adenocarcinoma Open
Addition of oxaliplatin or nab-paclitaxel to nal-IRI/FL was significantly associated with a better OS than regimen shifting after progression on nal-IRI/FL in patients with metastatic PDAC.
View article: Incorporating nivolumab with preceded gemcitabine and S-1 chemotherapy for patients of metastatic pancreatic cancer: a pilot study
Incorporating nivolumab with preceded gemcitabine and S-1 chemotherapy for patients of metastatic pancreatic cancer: a pilot study Open
Pancreatic ductal adenocarcinoma (PDAC) rarely responds to immune checkpoint inhibitors. We conducted a pilot study to investigate chemotherapy followed by the addition of nivolumab in metastatic PDAC with limited tumor burden. A single cy…
View article: Age-stratified analysis of the outcomes of craniotomy versus minimally invasive surgery in patients with spontaneous intracerebral hemorrhage
Age-stratified analysis of the outcomes of craniotomy versus minimally invasive surgery in patients with spontaneous intracerebral hemorrhage Open
Background: Spontaneous intracerebral hemorrhage (ICH), accounting for approximately 15%–40% of all stroke events, results in severe neurological deficits. Currently, the primary surgical interventions for ICH are traditional craniotomy an…
View article: Liposomes with Low Levels of Grafted Poly(ethylene glycol) Remain Susceptible to Destabilization by Anti-Poly(ethylene glycol) Antibodies
Liposomes with Low Levels of Grafted Poly(ethylene glycol) Remain Susceptible to Destabilization by Anti-Poly(ethylene glycol) Antibodies Open
Binding of anti-PEG antibodies to poly(ethylene glycol) (PEG) on the surface of PEGylated liposomal doxorubicin (PLD) in vitro and in rats can activate complement and cause the rapid release of doxorubicin from the liposome interior. Here,…
View article: A phase 1 study of biweekly nab-paclitaxel/oxaliplatin/S-1/LV for advanced upper gastrointestinal cancers: TCOG T1216 study
A phase 1 study of biweekly nab-paclitaxel/oxaliplatin/S-1/LV for advanced upper gastrointestinal cancers: TCOG T1216 study Open
Background Oxaliplatin- and fluoropyrimidine-based triplet regimens have demonstrated feasibility and efficacy in the treatment of upper gastrointestinal (UGI) cancers. Herein, we evaluate the feasibility and preliminary efficacy of biweek…
View article: Prognostic implications of distinctive imaging characteristics in primary intracranial germ cell tumors: A retrospective analysis
Prognostic implications of distinctive imaging characteristics in primary intracranial germ cell tumors: A retrospective analysis Open
Hemorrhage indicates worse prognosis. Intratumoral hemorrhage and ADC ratios differentiate germinoma from NGGCTs. Larger cohorts and advanced MR techniques are needed for future study.
View article: Targeted internalization and activation of glycosidic switch liposomes by an EphA2 PEG engager increases therapeutic efficacy against lung cancer
Targeted internalization and activation of glycosidic switch liposomes by an EphA2 PEG engager increases therapeutic efficacy against lung cancer Open
Glycosidic switch liposome (GSL) technology uses a reversible glucuronide ester to efficiently encapsulate and stably retain potent anticancer drugs in liposomes. Parental drug is generated by enzymatic hydrolysis of the glucuronide switch…
View article: Delay of Surgery for Spinal Metastasis due to the COVID-19 Outbreak Affected Patient Outcomes
Delay of Surgery for Spinal Metastasis due to the COVID-19 Outbreak Affected Patient Outcomes Open
Objective: The present study is to analyze the effects of the coronavirus disease 2019 (COVID 2019) outbreak and the subsequent lockdown on the outcomes of spinal metastasis patients.Methods: The study was a retrospective analysis of data …
View article: Spinal cord compression as the first manifestation of metastatic malignancies: A retrospective study of surgical outcomes from a single institution
Spinal cord compression as the first manifestation of metastatic malignancies: A retrospective study of surgical outcomes from a single institution Open
In conclusion, debulking surgery was shown to provide better neurological recoveries and could be considered first in patients with metastatic spinal cord compression as the first malignancy manifestation.
View article: Spinal metastases from non-small cell lung cancer: Is surgical extent enough by following suggestions of the Tomita and Tokuhashi scores?
Spinal metastases from non-small cell lung cancer: Is surgical extent enough by following suggestions of the Tomita and Tokuhashi scores? Open
Patients with spinal metastases from lung cancer had better prognosis than that predicted by the Tomita and Tokuhashi scores. Spine surgeons should acknowledge this discrepancy and treat these patients with at least the aggressiveness sugg…
View article: Improved nasal recovery and intact olfactory function after a transseptal approach for endoscopic endonasal transsphenoidal adenomectomy: A retrospective analysis
Improved nasal recovery and intact olfactory function after a transseptal approach for endoscopic endonasal transsphenoidal adenomectomy: A retrospective analysis Open
Objectives Endoscopic endonasal transsphenoidal adenomectomy (TSA) is the most frequently performed skull base surgery, and researchers have recently focused on preserving nasal function. The endoscopic transseptal approach is a promising …
View article: Fate and Transformation of 6:2 Fluorotelomer Sulfonic Acid Affected by Plant, Nutrient, Bioaugmentation, and Soil Microbiome Interactions
Fate and Transformation of 6:2 Fluorotelomer Sulfonic Acid Affected by Plant, Nutrient, Bioaugmentation, and Soil Microbiome Interactions Open
6:2 Fluorotelomer sulfonic acid (6:2 FTSA) is a dominant per- and poly-fluoroalkyl substance (PFAS) in aqueous film-forming foam (AFFF)-impacted soil. While its biotransformation mechanisms have been studied, the complex effects from plant…
View article: Minimally Invasive Neurosurgery for Spontaneous Intracerebral Hemorrhage—10 Years of Working Progress at National Taiwan University Hospital
Minimally Invasive Neurosurgery for Spontaneous Intracerebral Hemorrhage—10 Years of Working Progress at National Taiwan University Hospital Open
Intracerebral hemorrhage (ICH) is a life-threatening disease with a global health burden. Traditional craniotomy has neither improved functional outcomes nor reduced mortality. Minimally invasive neurosurgery (MIN) holds promise for reduci…
View article: RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus
RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus Open
RTL1/PEG11, which has been associated with anxiety disorders, is a retrotransposon-derived imprinted gene in the placenta. However, imprinting patterns and functions of RTL1 in the brain have not been well-investigated. We found Rtl1 was p…
View article: Better nasal recovery and intact olfactory function after transseptal approach for endoscopic endonasal transphenoidal adenomectomy: a retrospective analysis
Better nasal recovery and intact olfactory function after transseptal approach for endoscopic endonasal transphenoidal adenomectomy: a retrospective analysis Open
Objectives Endoscopic endonasal transsphenoidal adenomectomy (TSA) is the most frequently performed skull base surgery and researchers have recently focused on preserving nasal function. The transseptal approach is a promising procedure ow…
View article: Surgical application of endoscopic-assisted minimally-invasive neurosurgery to traumatic brain injury: Case series and review of literature
Surgical application of endoscopic-assisted minimally-invasive neurosurgery to traumatic brain injury: Case series and review of literature Open
Endoscopic-assisted MIN in TBI is safe and effective in a carefully selected group of patients.
View article: A Dynamic Interbody Cage Improves Bone Formation in Anterior Cervical Surgery: A Porcine Biomechanical Study
A Dynamic Interbody Cage Improves Bone Formation in Anterior Cervical Surgery: A Porcine Biomechanical Study Open
Background Anterior cervical discectomy and fusion (ACDF) with a rigid interbody spacer is commonly used in the treatment of cervical degenerative disc disease. Although ACDF relieves clinical symptoms, it is associated with several compli…
View article: Surgery for Coagulopathy-Related Intracerebral Hemorrhage: Craniotomy vs. Minimally Invasive Neurosurgery
Surgery for Coagulopathy-Related Intracerebral Hemorrhage: Craniotomy vs. Minimally Invasive Neurosurgery Open
Coagulopathy-related intracerebral hemorrhage (ICH) is life-threatening. Recent studies have shown promising results with minimally invasive neurosurgery (MIN) in the reduction of mortality and improvement of functional outcomes, but no pu…
View article: Metastatic Spinal Cord Compression as the First Manifestation of Malignancy – A Retrospective Study of Surgical Outcome from Single Institution Spine Tumor Registry
Metastatic Spinal Cord Compression as the First Manifestation of Malignancy – A Retrospective Study of Surgical Outcome from Single Institution Spine Tumor Registry Open
Given the limited studies addressing the issue about the effect of different surgical modalities for metastatic spinal cord compression (MSCC) as the first malignancy manifestation, we conducted a retrospective case-control study to evalua…
View article: Contribution of Nuclear BCL10 Expression to Tumor Progression and Poor Prognosis of Advanced and/or Metastatic Pancreatic Ductal Adenocarcinoma by Activating NF-κB-Related Signaling
Contribution of Nuclear BCL10 Expression to Tumor Progression and Poor Prognosis of Advanced and/or Metastatic Pancreatic Ductal Adenocarcinoma by Activating NF-κB-Related Signaling Open
Background: We previously demonstrated that nuclear BCL10 translocation participates in the instigation of NF-κB in breast cancer and lymphoma cell lines. In this study, we assessed whether nuclear BCL10 translocation is clinically signifi…
View article: Multicentre, phase II study of gemcitabine and S‐1 in patients with advanced biliary tract cancer: TG1308 study
Multicentre, phase II study of gemcitabine and S‐1 in patients with advanced biliary tract cancer: TG1308 study Open
Background & Aims Gemcitabine plus cisplatin (GC) remains the standard, frontline therapy for advanced biliary tract cancer (ABTC). The JCOG1113 study suggested that gemcitabine plus S‐1 (GS) had noninferior median overall survival and com…
View article: Complete Genome Sequence of Escherichia coli Siphophage Shashou
Complete Genome Sequence of Escherichia coli Siphophage Shashou Open
Here, we announce the genome of the Escherichia coli 4s siphophage Shashou, which presents similarity to members of the Guernseyvirinae subfamily. Shashou is predicted to use a headful packaging mechanism for its 44,155-bp genome and to en…