Shihong Max Gao
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View article: Form and function of actin impacts actin health and aging
Form and function of actin impacts actin health and aging Open
The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systematically interrogated how genetic and phar…
View article: Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts
Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts Open
Microbiota-derived metabolites have emerged as key regulators of longevity. The metabolic activity of the gut microbiota, influenced by dietary components and ingested chemical compounds, profoundly impacts host fitness. While the benefits…
View article: Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans
Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans Open
Metabolism is fundamental to organism physiology and pathology. From the intricate network of metabolic reactions, diverse chemical molecules, collectively termed metabolites, are produced. In multicellular organisms, metabolite communicat…
View article: Quantitative profiling pH heterogeneity of acidic endolysosomal compartments using fluorescence lifetime imaging microscopy
Quantitative profiling pH heterogeneity of acidic endolysosomal compartments using fluorescence lifetime imaging microscopy Open
The endolysosomal system plays a crucial role in maintaining cellular homeostasis and promoting organism fitness. The pH of its acidic compartments is a crucial parameter for proper function, and it is dynamically influenced by both intrac…
View article: Cross-Tissue Coordination between SLC Nucleoside Transporters Regulates Reproduction in<i>Caenorhabditis elegans</i>
Cross-Tissue Coordination between SLC Nucleoside Transporters Regulates Reproduction in<i>Caenorhabditis elegans</i> Open
Metabolism is fundamental to organism physiology and pathology. From the intricate network of metabolic reactions, diverse chemical molecules, collectively termed as metabolites, are produced. In multicellular organisms, metabolite communi…
View article: Cell-surface Milieu Remodeling in Human Dendritic Cell Activation
Cell-surface Milieu Remodeling in Human Dendritic Cell Activation Open
Dendritic cells (DCs) are specialized sentinel and APCs coordinating innate and adaptive immunity. Through proteins on their cell surface, DCs sense changes in the environment, internalize pathogens, present processed Ags, and communicate …
View article: Aging atlas reveals cell-type-specific effects of pro-longevity strategies
Aging atlas reveals cell-type-specific effects of pro-longevity strategies Open
Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan across species. However, how age-related molecular changes differ among various tissues and…
View article: Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity Open
Lysosomes are active sites to integrate cellular metabolism and signal transduction. A collection of proteins associated with the lysosome mediate these metabolic and signaling functions. Both lysosomal metabolism and lysosomal signaling h…
View article: Author response: Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
Author response: Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Lysosom…
View article: Mitochondrial GTP metabolism controls reproductive aging in C. elegans
Mitochondrial GTP metabolism controls reproductive aging in C. elegans Open
Healthy mitochondria are critical for reproduction. During aging, both reproductive fitness and mitochondrial homeostasis decline. Mitochondrial metabolism and dynamics are key factors in supporting mitochondrial homeostasis. However, how …
View article: Mitochondrial GTP Metabolism Regulates Reproductive Aging
Mitochondrial GTP Metabolism Regulates Reproductive Aging Open
SUMMARY Healthy mitochondria are critical for reproduction. During aging, both reproductive fitness and mitochondrial homeostasis decline. Mitochondrial metabolism and dynamics are key factors in supporting mitochondrial homeostasis. Howev…
View article: Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies
Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies Open
Organism aging occurs at the multicellular level; however, how pro-longevity mechanisms slow down aging in different cell types remains unclear. We generated single-cell transcriptomic atlases across the lifespan of Caenorhabditis elegans …
View article: Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity Open
Lysosomes are active sites to integrate cellular metabolism and signal transduction. A collection of proteins associated with the lysosome mediate these metabolic and signaling functions. Both lysosomal metabolism and lysosomal signaling h…
View article: Molecular Mechanisms of Lysosome and Nucleus Communication
Molecular Mechanisms of Lysosome and Nucleus Communication Open
View article: Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans
Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans Open
View article: The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking
The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking Open
The correct establishment and maintenance of unidirectional Notch signaling are critical for the homeostasis of various stem cell lineages. However, the molecular mechanisms that prevent cell-autonomous ectopic Notch signaling activation a…
View article: Author response: The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking
Author response: The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The correct establishment and…
View article: The Super Elongation Complex Drives Neural Stem Cell Fate Commitment
The Super Elongation Complex Drives Neural Stem Cell Fate Commitment Open