Shanshan Zeng
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View article: PLATZ transcription factors: Roles in plant growth, development, and stress adaptation
PLATZ transcription factors: Roles in plant growth, development, and stress adaptation Open
View article: The role of inflammation in Ischemic stroke: from biomarker to treatment
The role of inflammation in Ischemic stroke: from biomarker to treatment Open
Stroke ranks among the most prevalent diseases globally. Ischemic stroke (IS), constituting 87% of all strokes, poses a significant threat to patients’ health. Following the onset of IS, within a few minutes, inflammation is initiated. Thi…
View article: Comparison of the Efficacy of Different Exercise Modes on MCI Adults: A Network Meta‐Analysis
Comparison of the Efficacy of Different Exercise Modes on MCI Adults: A Network Meta‐Analysis Open
Background Mild cognitive impairment (MCI) is considered a preclinical or prodromal stage of Alzheimer's disease (AD). MCI patients have an annual probability of progression to dementia of 10%–15%, far higher than the normal elderly (∼1%–2…
View article: 5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth
5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth Open
This study reveals a previously unrecognized dual role of 5-oxoproline, which functions both as an early biomarker for DOX-induced cardiotoxicity detection and as a therapeutic target that simultaneously inhibits cancer growth and protects…
View article: BHLHA15 promotes cervical cancer cholesterol synthesis and tumor progression
BHLHA15 promotes cervical cancer cholesterol synthesis and tumor progression Open
Research suggested that increased cholesterol synthesis is an effect factor in the malignant progression and unfavorable outcome of cervical cancer (CC). Unfortunately, the molecular mechanisms underlying the increased cholesterol synthesi…
View article: Corrigendum to “Fruquintinib in refractory metastatic colorectal cancer: a multicenter real-world study”
Corrigendum to “Fruquintinib in refractory metastatic colorectal cancer: a multicenter real-world study” Open
View article: Acute myeloid leukemia with NPM1, IDH2, and SETD2 mutations mimicking acute promyelocytic leukemia: A case report and literature review
Acute myeloid leukemia with NPM1, IDH2, and SETD2 mutations mimicking acute promyelocytic leukemia: A case report and literature review Open
Rationale: Acute myeloid leukemia with NPM1, IDH2 , and SETD2 mutations can mimic acute promyelocytic leukemia (APL) and poses a challenge for the early and accurate differentiation and diagnosis of APL with PML::RARA . Patient concerns: A…
View article: Fruquintinib in refractory metastatic colorectal cancer: a multicenter real-world study
Fruquintinib in refractory metastatic colorectal cancer: a multicenter real-world study Open
View article: Circ-FOXO3 inhibits triple-negative breast cancer progression via interaction with WHSC1
Circ-FOXO3 inhibits triple-negative breast cancer progression via interaction with WHSC1 Open
Background . Circular RNAs (circRNAs), a subclass of non-coding RNAs characterized by covalently closed continuous loops, play a key role in tumorigenesis and aggressiveness. However, the potential molecular mechanism of circRNAs in triple…
View article: P-276 Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription
P-276 Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription Open
Study question Whether the activation of DUX4, a key inducer in the process of zygotic genome activation (ZGA), is associated with telomere length. Summary answer Telomeres regulate the expression of DUX4/Dux through chromatin remodeling a…
View article: JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2
JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2 Open
Decidualization of human endometrial stromal cells (hESCs) is essential for the maintenance of pregnancy, which depends on the fine-tuned regulation of hESCs survival, and its perturbation contributes to pregnancy loss. However, the underl…
View article: Supplementary Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
Supplementary Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer Open
Supplementary Data from ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
View article: Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer Open
Resistance to HER2-targeted therapy represents a significant challenge for the successful treatment of patients with breast cancer with HER2-positive tumors. Through a global mass spectrometry–based proteomics approach, we discovered that …
View article: Supplementary Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
Supplementary Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer Open
Supplementary Data from ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
View article: Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
Data from ALKBH5-Mediated m<sup>6</sup>A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer Open
Resistance to HER2-targeted therapy represents a significant challenge for the successful treatment of patients with breast cancer with HER2-positive tumors. Through a global mass spectrometry–based proteomics approach, we discovered that …
View article: TNFα/TNFR1 signal induces excessive senescence of decidua stromal cells in recurrent pregnancy loss
TNFα/TNFR1 signal induces excessive senescence of decidua stromal cells in recurrent pregnancy loss Open
Defects in decidual response are associated with adverse pregnancy outcomes which includes recurrent pregnancy loss (RPL). It is reported that cellular senescence happens during decidualization and pro-senescent decidual response in the lu…
View article: ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer Open
Resistance to HER2-targeted therapy represents a significant challenge for the successful treatment of patients with breast cancer with HER2-positive tumors. Through a global mass spectrometry–based proteomics approach, we discovered that …
View article: Grass Carp Mex3A Promotes Ubiquitination and Degradation of RIG-I to Inhibit Innate Immune Response
Grass Carp Mex3A Promotes Ubiquitination and Degradation of RIG-I to Inhibit Innate Immune Response Open
As one of the Mex3 family members, Mex3A is crucial in cell proliferation, migration, and apoptosis in mammals. In this study, a novel gene homologous to mammalian Mex3A (named CiMex3A , MW368974) was cloned and identified in grass carp, w…
View article: Association between the second-stage duration of labor and perinatal outcomes in women with a prior cesarean delivery
Association between the second-stage duration of labor and perinatal outcomes in women with a prior cesarean delivery Open
View article: Tumor-associated macrophages promote epithelial–mesenchymal transition and the cancer stem cell properties in triple-negative breast cancer through CCL2/AKT/β-catenin signaling
Tumor-associated macrophages promote epithelial–mesenchymal transition and the cancer stem cell properties in triple-negative breast cancer through CCL2/AKT/β-catenin signaling Open
Background Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with poor prognosis and limited treatment. As a major component of the tumor microenvironment, tumor-associated macrophages (TAMs) play an impo…
View article: Sequencing and Structural Characteristic Analysis of Mitochondrial Genome in Zhijin White Goose(Anser cygnoides)
Sequencing and Structural Characteristic Analysis of Mitochondrial Genome in Zhijin White Goose(Anser cygnoides) Open
Zhijin White Goose has the characteristics of fast growth, good fattening performance, fresh and high-quality meat, rough feeding resistance, and strong disease resistance. It is a precious white goose resource unique to Guizhou Province, …
View article: Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cells
Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cells Open
View article: Cellular and molecular atlas of the placenta from a COVID‐19 pregnant woman infected at midgestation highlights the defective impacts on foetal health
Cellular and molecular atlas of the placenta from a COVID‐19 pregnant woman infected at midgestation highlights the defective impacts on foetal health Open
Objectives The impacts of the current COVID‐19 pandemic on maternal and foetal health are enormous and of serious concern. However, the influence of SARS‐CoV‐2 infection at early‐to‐mid gestation on maternal and foetal health remains uncle…
View article: Risk Factors and Pregnancy Outcome in Women with a History of Cesarean Section Complicated by Placenta Accreta
Risk Factors and Pregnancy Outcome in Women with a History of Cesarean Section Complicated by Placenta Accreta Open
Objective: To explore the risk factors and pregnancy outcomes in women with a history of cesarean section complicated by placenta accreta (PA). Methods: This case-control study included clinical data from singleton mothers with a history o…
View article: Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion
Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion Open
Objectives Successful pregnancy involves the homeostasis between maternal decidua and fetoplacental units, whose disruption contributes to compromised pregnancy outcomes, including recurrent spontaneous abortion (RSA). The role of cell het…
View article: RNA-sequence reveals differentially expressed genes affecting the crested trait of Wumeng crested chicken
RNA-sequence reveals differentially expressed genes affecting the crested trait of Wumeng crested chicken Open
Wumeng crested chicken has a cluster of slender feathers on its head, and the underlying skull region exhibits an obvious tumor-like protrusion. This is the typical skull structure of crested chickens. The associated regulatory genes are l…
View article: Probability of severe postpartum hemorrhage in repeat cesarean deliveries: a multicenter retrospective study in China
Probability of severe postpartum hemorrhage in repeat cesarean deliveries: a multicenter retrospective study in China Open
View article: Effect of types of placenta previa on maternal and neonatal outcomes: A 10-year retrospective cohort study
Effect of types of placenta previa on maternal and neonatal outcomes: A 10-year retrospective cohort study Open
Purpose : Through this study, we aimed to evaluate the effects of different types of placenta previa (PP) on maternal and neonatal outcomes. Methods : This study was conducted in The Third Affiliated Hospital of Guangzhou Medical Universit…
View article: Maternal age at first cesarean delivery related to adverse pregnancy outcomes in a second cesarean delivery: a multicenter, historical, cross-sectional cohort study
Maternal age at first cesarean delivery related to adverse pregnancy outcomes in a second cesarean delivery: a multicenter, historical, cross-sectional cohort study Open
View article: Risk Factors and Pregnancy Outcome in Women With a History of Cesarean Section Complicated by Placenta Accreta
Risk Factors and Pregnancy Outcome in Women With a History of Cesarean Section Complicated by Placenta Accreta Open
Objective: To explore the risk factors and pregnancy outcomes in women with a history of cesarean section complicated by placenta accreta. Methods: This retrospective study included clinical data from singleton mothers with a history of ce…