Shiliang Tu
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View article: Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages
Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages Open
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which increases the incidence of colorectal cancer (CRC). In the pathophysiology of IBD, ubiquitination/deubiquitination plays a critical re…
View article: Groundwater Geochemistry in the Karst-Fissure Aquifer System of the Qinglian River Basin, China
Groundwater Geochemistry in the Karst-Fissure Aquifer System of the Qinglian River Basin, China Open
The Qinglian River plays a significant role in China’s national water conservation security patterns. To clarify the relationship between hydrogeochemical properties and groundwater quality in this karst-fissure aquifer system, drilling da…
View article: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer
EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer Open
EEPD1 was dysregulated in human cancers and correlated with various cancer patient prognoses. The dysregulated EEPD1 expression can affect tumor-infiltrating immune cells and immunotherapy response. Therefore, EEPD1 could act as an oncogen…
View article: Risk factors for anastomotic leak and postoperative morbidity after right hemicolectomy for colon cancer: results from a prospective, multi-centre, snapshot study in China
Risk factors for anastomotic leak and postoperative morbidity after right hemicolectomy for colon cancer: results from a prospective, multi-centre, snapshot study in China Open
Background Right hemicolectomy is the standard treatment for right-sided colon cancer. There is variation in the technical aspects of performing right hemicolectomy as well as in short-term outcomes. It is therefore necessary to explore be…
View article: BHLHE41 Overexpression Alleviates the Malignant Behavior of Colon Cancer Cells Induced by Hypoxia via Modulating HIF-1α/EMT Pathway
BHLHE41 Overexpression Alleviates the Malignant Behavior of Colon Cancer Cells Induced by Hypoxia via Modulating HIF-1α/EMT Pathway Open
Objective. BHLHE41 has been shown to be a marker of tumorigenesis. Colon cancer (CC) is a common malignant tumor of colonic mucosa. This study mainly explored the mechanism of BHLHE41 in alleviating malignant behavior of hypoxia-induced CC…
View article: A tumoral and peritumoral CT-based Radiomics and Machine learning approach to predict the microsatellite instability of rectal carcinoma
A tumoral and peritumoral CT-based Radiomics and Machine learning approach to predict the microsatellite instability of rectal carcinoma Open
Objective: To predict the status of microsatellite instability (MSI) of rectal carcinoma (RC) using different machine learning algorithms based on tumoral and peritumoral radiomics combined with clinicopathological characteristics. Methods…
View article: An Integrating of Clinical, Pathological, and Radiomic Approach to Predict the Microsatellite Instability in Rectal Carcinoma
An Integrating of Clinical, Pathological, and Radiomic Approach to Predict the Microsatellite Instability in Rectal Carcinoma Open
Objective: To develop an integrative model with clinical, pathological, and radiomic characteristics to predict the status of microsatellite instability (MSI) in rectal carcinoma (RC). Methods: A cohort of 788 RCs with 97 high MSI status (…
View article: Downregulation of lncRNA RPLP0P2 inhibits cell proliferation, invasion and migration, and promotes apoptosis in colorectal cancer
Downregulation of lncRNA RPLP0P2 inhibits cell proliferation, invasion and migration, and promotes apoptosis in colorectal cancer Open
Recent studies have revealed that long noncoding RNAs (lncRNAs) are closely associated with colorectal cancer (CRC); however, the role of the lncRNA RPLP0P2 in CRC remains largely unknown. In the present study, RNA expression profiles of C…
View article: Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1
Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1 Open
Heat shock factor 1 (HSF1) is a powerful multifaceted oncogenic modifier that plays a role in maintaining the protein balance of cancer cells under various stresses. In recent studies, there have been reports of increased expression of HSF…
View article: MEIS2 promotes cell migration and invasion in colorectal cancer
MEIS2 promotes cell migration and invasion in colorectal cancer Open
Colorectal cancer (CRC) is one of the most common types of malignancy worldwide. Distant metastasis is a key cause of CRC-associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mec…
View article: Lymphovascular invasion is a high risk factor for stage I/II colorectal cancer: a systematic review and meta-analysis
Lymphovascular invasion is a high risk factor for stage I/II colorectal cancer: a systematic review and meta-analysis Open
The prognostic value of lymphovascular invasion (LVI) in stage I/II colorectal cancer (CRC) does not reach a consensus. To systematically assess prognostic significance of LVI, databases of PubMed, Web of Science, and Embase were searched …
View article: Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer
Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer Open