Explanipedia

Innovative strategies for anti-fibrotic drugs discovery from traditional Chinese medicine Open

Guang Xin, Litao Wang, Qilong Zhou, Sanyin Zhang, Zeliang Wei , et al. · 2025

Metabolomic and Single‐Cell Transcriptomic Analyses Shed Light on Secondary Metabolite Profiling and Potential Developmental Dynamics of Glandular Trichomes in <i>Artemisia argyi</i> Open

Shuting Dong, Hongyu Chen, Sijie Sun, Miaoxian Guo, Chao Sun , et al. · 2025

Plant glandular trichomes (GTs) are characterised by their ability to synthesise and store abundant secondary metabolites of significant biological importance. The medicinal plant Artemisia argyi exhibits a dense covering of GTs, yet the p…

Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions Open

Gang Fan, Shilin Chen, Qingping Zhang, Na Yu, Zhi‐Xun Shen , et al. · 2025

Targeted protein degradation (TPD) represents a paradigm shift in drug discovery, moving beyond traditional binding‐based inhibition toward active removal of disease‐driving proteins. This approach has unlocked therapeutic possibilities fo…

Wastewater-Based Surveillance of SARS-CoV-2 and Modeling of COVID-19 Infection Trends Open

Wenli Wang, Ruoyu Li, Shilin Chen, Liangping Chen, Yu Jiang , et al. · 2025

Background: This study was performed to evaluate the early warning value of wastewater-based epidemiology (WBE) in monitoring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its correlation with population-level coronaviru…

Mitochondrial Transplantation: A Paradigm Shift in Osteoporosis Therapy Open

Jianlin Shen, Yue Lai, Qinglin Peng, X. Lin, Shilin Chen , et al. · 2025

Osteoporosis, a global health crisis marked by compromised bone mineral density and heightened fracture susceptibility, demands innovative therapeutic strategies beyond conventional anti-resorptive approaches. Mitochondrial dysfunction, ch…

Trained immunity modulators: A new frontier in immunoregulation and disease intervention Open

Jiao Chen, Chenxi Wang, Shilin Chen, Hui Cai, Mengke Wang , et al. · 2025

This review aims to elucidate the molecular mechanisms underlying trained immunity and its dual roles in various pathological conditions. We provide a comprehensive summary of the classifications and mechanisms of trained immunity inducers…

MedMeta: An AI-Enabled and Genomics-Based Database for Functional Profiling of Secondary Metabolites in Medicinal Species Open

Fanbo Meng, Gui-Yang Zhang, Wenke Xiao, Yufei Mao, Yun Shu , et al. · 2025

Top 10 academic advances in traditional Chinese medicine in 2024 Open

Jihua Guo, Shukun Gong, Xiaoxiao Zhang, Wei Wei, Peijing Rong , et al. · 2025

Pan-Mitochondrial Genomic Analysis of Ginseng (Panax ginseng) Reveals Structural Variation, Phylogenetic Relationships, and Genetic Diversity Open

Yue Xi, Xuejiao Liao, Haoyu Hu, Shuiming Xiao, Shuai Guo , et al. · 2025

Ginseng (Panax ginseng), a vital medicinal plant, faces challenges in genetic stability and directed breeding. This study aimed to elucidate mitochondrial genome structure, evolution, and phylogenetic relationships to guide germplasm conse…

Integrative Transcriptome and Metabolome Analysis Identifies Potential Pathways Associated with Cadmium Tolerance in Two Maize Inbred Lines Open

Ping-xi WANG, Min Li, Xingye Ma, Bin Zhao, Xining Jin , et al. · 2025

Cadmium (Cd) significantly influences the morphological, physiological traits, and transport capacity of plants, but the underlying mechanism of Cd stress still remains to be further studied. In this study, physiological, transcriptomic, a…

Self-knowledge distillation for prediction of breast cancer molecular subtypes based on digital breast tomosynthesis Open

Wei Guo, Jinhua Bo, Shilin Chen, Zhaoxuan Gong, Guodong Zhang , et al. · 2025

This study aims to investigate the effectiveness of self-knowledge distillation (self-KD) with progressive refinement in the early prediction of molecular subtypes of breast cancer (BC) using digital breast tomosynthesis (DBT) images. This…

Artificial intelligence-curated repository of gene-encoded natural diverse components from herbal medicines Open

Wei Chen, Zhiyin Yu, Liang Leng, Dan Sun, Hao Liu , et al. · 2025

Genomic characterization of AP2/ERF transcription factors related to cannabinoids biosynthesis in Cannabis sativa Open

Wei Yao, Su LiRong, Zhimei Lu, Jitong Chen, Lixin Duan , et al. · 2025

Ten recommendations for the high-quality development of traditional Chinese medicine in the new era Open

Boli Zhang, Erdan Dong, Liang Liu, Jinzhou Tian, Shilin Chen , et al. · 2025

Arbuscular Mycorrhizal Fungi Mitigate Lead Toxicity in Maize by Restructuring Rhizosphere Microbiome and Enhancing Antioxidant Defense Mechanisms Open

Xiaoxiang Zhang, Bin Zhao, Yan Zheng, Man Li, Huaisheng Zhang , et al. · 2025

The remediation of lead (Pb)-contaminated soils through eco-friendly strategies is critical for sustainable agriculture. This study investigated the role of arbuscular mycorrhizal fungi (AMF) in enhancing maize tolerance to Pb stress and m…

Rheumatoid arthritis and chronic obstructive pulmonary disease in US adults: a cross-sectional analysis Open

Panpan Mi, Huijie Wang, Guofeng Fan, Shilin Chen, Xiaoyuan Chen , et al. · 2025

Background Globally, chronic obstructive pulmonary disease (COPD) has emerged as one of the most prevalent chronic respiratory disorders, imposing substantial healthcare challenges and contributing significantly to premature mortality. Eme…

Genetic and genomic insights into dichogamy in Zingiberaceae Open

Shanshan Chen, Xiao-Chang Peng, Ziyan Xie, Mengmeng Zhang, Ao-Dan Huang , et al. · 2025

Study on the leaf epidermis micromorphology of six medicinal plant species in Smilax from Henan Province Open

Xin Luo, Conglong Lian, Y Zhang, Xiu-Hong Su, Shilin Chen · 2025

Expert consensus on the positioning of the “Three-in-One” Registration and Evaluation Evidence System and the value of orientation of the “personal experience” Open

Qi Wang, Yongyan Wang, Xiaoyong Wei, Jin-zhou Tian, Shilin Chen , et al. · 2025

Combination Treatment of Rituximab and Therapeutic Vaccines Affords Superior Tumor Suppression and Relapse Prevention for Non‐Hodgkin Lymphoma Open

Tong Qi, Jimin Guo, Zheng Cao, Shilin Chen, E Kimura , et al. · 2025

Lymphoma, a common malignancy of the lymphatic system, presents considerable health challenges and imposes a significant economic burden. Despite advancements in chemotherapy and immunotherapy that have improved survival rates, issues such…

Wireless bioelectronic devices for next-generation electrotherapy Open

Longfei Chen, Shilin Chen, Bin Sun, Jia‐Yang Chen, Yamin Zhang · 2025

Comprehensive characterization of volatile terpenoids and terpene synthases in Lanxangia tsaoko Open

Shanshan Chen, Mofan Zhang, Shuo Ding, Zhichao Xu, Sifan Wang , et al. · 2025

Lanxangia tsaoko is widely utilized in human cuisine as a popular flavoring agent due to its distinctive aroma. It also has a long history of use in traditional Chinese medicine. The edible and medicinal properties of L. tsaoko are primari…

Superior sulfur conversion reaction on phosphorus-doped carbon dot/graphene composites for Li–S batteries in a wide working temperature range Open

Shilin Chen, Kaijie Miao, Jiangqi Zhou · 2025

Karyotype and genome size analyses for two spiders of the lycosidae family Open

Yuxuan Zhang, Mengying Zhang, Liang Leng, Ya Fang Wu, Hanting Yang , et al. · 2025

Background Karyotype and genome size are critical genetic characteristics with significant value for cytogenetics, taxonomy, phylogenetics, evolution, and molecular biology. The Lycosidae family, known for its diverse spiders with varying …

Comparative genomics provides insights into the biogeographic and biochemical diversity of meliaceous species Open

Jia Liu, Zhennan Wang, Xinyao Su, Liang Leng, Jiarou Liu , et al. · 2025

Meliaceous plants such as Azadirachta indica (neem) and Melia azedarach (chinaberry) contain large amounts of limonoids with unique anti-insect activities. However, genes responsible for downstream modifications of limonoids are not well k…

The Nothapodytes nimmoniana genome provides insights into the independent evolution of camptothecin biosynthesis in asterids Open

Xiaofeng Shen, Xiaofeng Shen, Zhijing Guan, Sijie Sun, Ke Du , et al. · 2025

Nothapodytes nimmoniana is known to produce the highest content of the anticancer compound camptothecin (CPT) in the plant kingdom. We present the chromosome-level allotetraploid genome of N. nimmoniana, marking the first genome sequence f…

Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective Open

Zenghao Bi, Huan Li, Yuting Liang, Dan Sun, S.-L. Liu , et al. · 2025

Traditional medicines serve not only as an integral part of medical treatments prescribed by healthcare providers but also as a fundamental reservoir for novel molecular scaffolds. However, gaps remain in our understanding of the mechanism…

Integrated Physiological, Transcriptomic and Metabolomic Analysis Revealed Heterosis for Cadmium Tolerance in Maize Open

Pingxi Wang, Min Li, Xingye Ma, Bin Zhao, Xining Jin , et al. · 2025

Integrated Physiological, Transcriptomic and Metabolomic Analysis Revealed Heterosis for Cadmium Tolerance in Maize Open

Pingxi Wang, Min Li, Xingye Ma, Bin Zhao, Xining Jin , et al. · 2025

Preparation and mechanism of environmentally friendly poly-citrulline as shale inhibitor for water-based drilling fluids Open

Baojun Li, Pingya Luo, Danchao Huang, Qiang Fu, Leichuan Tan , et al. · 2025

Shale inhibitors is a treatment agent in mud, but most inhibitors cannot balance the relationship between inhibition performance and environmental protection performance.

Shilin Chen YOU? Author Swipe