Shiling Hu
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View article: Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases
Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases Open
Allergic inflammation is closely related to the activation of mast cells (MCs), which is regulated by its intracellular Ca2+ level, but the intake and effects of the intracellular Ca2+ remain unclear. The Ca2+ influx is controlled by membe…
View article: Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion
Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion Open
Fusion with host cell membrane is the main mechanism of infection of SARS-CoV-2. Here, we propose a new strategy to double block SARS-CoV-2 membrane fusion by using Harringtonine (HT), a small-molecule antagonist. By using cell membrane ch…
View article: Antiviral drugs suppress infection of 2019‐nCoV spike pseudotyped virus by interacting with ACE2 protein
Antiviral drugs suppress infection of 2019‐nCoV spike pseudotyped virus by interacting with ACE2 protein Open
The outbreak of coronavirus disease 2019 (COVID‐19) has induced a large number of deaths worldwide. Angiotensin‐converting enzyme 2 (ACE2) is the entry receptor for the 2019 novel coronavirus (2019‐nCoV) to infect the host cells. Therefore…
View article: Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2
Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2 Open
Since December 2019, the new coronavirus (also known as severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2, 2019‐nCoV])—induced disease, COVID‐19, has spread rapidly worldwide. Studies have reported that the traditional Chinese me…