Explanipedia

A qualitative study on the supportive care needs of postoperative lung cancer patients during home rehabilitation Open

Siyang Feng, Xiangcheng Lei, Na Li, Yuanyuan Song, Jianhui Li · 2025

Objective To gain an in-depth understanding of the supportive care needs of lung cancer patients during home-based rehabilitation after surgery, and to provide a reference for developing scientific intervention strategies. Methods Based on…

Weakly Supervised Gland Segmentation with Class Semantic Consistency and Purified Labels Filtration Open

Siyang Feng, Huadeng Wang, Chu Han, Zhenbing Liu, Hualong Zhang , et al. · 2025

Image-level weakly supervised semantic segmentation (WSSS) reduces the dependence on high-quality data annotation, which plays a crucial role in computational pathology. Benefit from the ability to localize the objects with only binary lab…

CA-MLIF: Cross-Attention and Multimodal Low-Rank Interaction Fusion Framework for Tumor Prognostic Prediction Open

Yajun An, Jiale Chen, Huan Lin, Zhenbing Liu, Siyang Feng , et al. · 2025

Cancer is a leading cause of death worldwide due to its aggressive nature and complex variability. Accurate prognosis is therefore challenging but essential for guiding personalized treatment and follow-up. Previous research often relied o…

Recalibration of four empirical reference crop evapotranspiration models using a hybrid Differential Evolution-Grey Wolf Optimizer algorithm Open

Long Zhao, Shuo Yang, Xinbo Zhao, Yi Shi, Siyang Feng , et al. · 2025

Spatial distance between tumor and lymphocyte can predict the survival of patients with resectable lung adenocarcinoma Open

Xipeng Pan, Siyang Feng, Yumeng Wang, Jiale Chen, Huan Lin , et al. · 2024

Recalibration of four empirical reference crop evapotranspiration models using a hybrid Differential Evolution-Grey Wolf Optimizer algorithm Open

Long Zhao, Shuo Yang, Xinbo Zhao, Yi Shi, Siyang Feng , et al. · 2024

Lesionmix Data Enhancement and Entropy Minimization for Semi-Supervised Lesion Segmentation of Lung Cancer Open

Xipeng Pan, Mingwei Chen, Huan Lin, Xinjun Bian, Siyang Feng , et al. · 2024

Plasma cell-free DNA 5-hydroxymethylcytosine and whole-genome sequencing signatures for early detection of esophageal cancer Open

Di Lu, Xuanzhen Wu, Wendy Wu, Shuangxiu Wu, Hui Li , et al. · 2023

Esophageal cancer is a highly incidence and deadly disease with a poor prognosis, especially in developing countries. Owing to the lack of specific symptoms and early diagnostic biomarkers, most patients are diagnosed with advanced disease…

A comparative study on epidemiological characteristics, transmissibility, and pathogenicity of three COVID-19 outbreaks caused by different variants Open

Chan Liu, Jianhua Lu, Peihua Li, Siyang Feng, Yichao Guo , et al. · 2023

A Prognostic Model for Colon Adenocarcinoma Patients Based on Ten Amino Acid Metabolism Related Genes Open

Yangzi Ren, Shangwen He, Siyang Feng, Wei Yang · 2022

Background Amino acid metabolism plays a vital role in cancer biology. However, the application of amino acid metabolism in the prognosis of colon adenocarcinoma (COAD) has not yet been explored. Here, we construct an amino acid metabolism…

Plasma Cell-free DNA 5-Hydroxymethylcytosine and Whole-Genome Sequencing Signatures for Early Detection of Esophageal Cancer Open

Di Lu, Xuanzhen Wu, Shuangxiu Wu, Hui Li, Yan Xue-bin , et al. · 2022

Background Esophageal cancer is one of globally high incidence and mortality disease. Its early stage has rarely obvious symptoms. Compared to conventional endoscopy diagnosis, liquid biopsy is an emerging non-invasive method for cancer ea…

Authors' response: Comment on “clinicopathological features, survival outcomes, and appropriate surgical approaches for stage I acinar and papillary predominant lung adenocarcinoma” Open

Di Lu, Jianjun Yang, Xiguang Liu, Siyang Feng, Xiaoying Dong , et al. · 2022

Some concerns were raised related to our study in the comments, which was published earlier in Cancer Medicine “Clinicopathological features, survival outcomes, and appropriate surgical approaches for stage I acinar and papillary predomina…

Plasma Cell-Free DNA 5-Hydroxymethylcytosine and Whole-Genome Sequencing Signatures for Early Detection of Esophageal Cancer Open

Di Lu, Xuanzhen Wu, Shuangxiu Wu, Hui Li, Yan Xue-bin , et al. · 2022

Ideal Anatomical Landmark Points for Thoracic Esophagus Segmentation in the Chinese Population Open

Di Lu, Xiuyu Ji, Jintao Zhan, Jianxue Zhai, T. Fang , et al. · 2021

Introduction: The standards of esophagus segmentation remain different between the Japan Esophageal Society (JES) guideline and the Union for International Cancer Control (UICC)/American Joint Committee on Cancer (AJCC) guideline. This stu…

LncRNA miR205HG hinders HNRNPA0 translation: anti‐oncogenic effects in esophageal carcinoma Open

Xiaoying Dong, Xuyuan Chen, Di Lu, Dingwei Diao, Xiguang Liu , et al. · 2021

Esophageal carcinoma (ESCA) affects 4 450 000 people and causes approximately 400 000 deaths annually worldwide, making it the sixth most lethal and eighth most common cancer. Patients with ESCA are often diagnosed at the later stages in w…

Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling Open

Juanjuan Yuan, Ting Cai, Xiaojun Zheng, Yangzi Ren, Jingwen Qi , et al. · 2021

A correction to this paper has been published: https://doi.org/10.1007/s13238-021-00833-y

Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling Open

Juanjuan Yuan, Ting Cai, Xiaojun Zheng, Yangzi Ren, Jingwen Qi , et al. · 2021

Metabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as a key component of this regulation remains largely unexplored. Herein, we found that the low-density lipoprotein …

Mapping the Trends in Esophageal Cancer Disease Burden in the United States: Results from the Global Burden of Disease Study 2017 Open

Di Lu, Jianxue Zhai, Jintao Zhan, Xiguang Liu, Xiaoying Dong , et al. · 2021

Background : Esophageal cancer is the 10th leading cancer in US but given limited research attention. This study aimed to investigate the esophageal cancer disease burden more comprehensively in US. Methods : Having retrieved states-catego…

Spontaneous versus mechanical ventilation during video-assisted thoracoscopic surgery for spontaneous pneumothorax: A randomized trial Open

Jun Liu, Hengrui Liang, Fei Cui, Hui Liu, Chengchu Zhu , et al. · 2021

The first comprehensive database of germline pathogenic variants in East Asian cancer patients Open

Xiaoshun Shi, Ruidong Li, Jianxue Zhai, Allen Chen, Kailing Huang , et al. · 2021

Pathogenic germline variants in cancer-associated genes are risk factors for cancer predisposition. However, systematic mining and summarizing of cancer pathogenic or likely pathogenic variants has not been performed for people of East Asi…

Three Survival‐Related Genes of Esophageal Squamous Cell Carcinoma Identified by Weighted Gene Coexpression Network Analysis Open

Di Lu, He Wang, Xuanzhen Wu, Jianxue Zhai, Xiguang Liu , et al. · 2021

Background . The aim of this study was to identify novel biomarkers associated with esophageal squamous cell carcinoma (ESCC) prognosis. Methods . 81 ESCC samples collected from The Cancer Genome Atlas (TCGA) were used as the training set,…

Machine Learning Models to Predict Primary Sites of Metastatic Cervical Carcinoma From Unknown Primary Open

Di Lu, Jianjun Jiang, Xiguang Liu, He Wang, Siyang Feng , et al. · 2020

Metastatic cervical carcinoma from unknown primary (MCCUP) accounts for 1–4% of all head and neck tumors, and identifying the primary site in MCCUP is challenging. The most common histopathological type of MCCUP is squamous cell carcinoma …

Potentiating CD8<sup>+</sup>T cell antitumor activity by targeting the PCSK9/LDLR axis Open

Juanjuan Yuan, Ting Cai, Xiaojun Zheng, Yangzi Ren, Jinwen Qi , et al. · 2020

Metabolic regulation has proven to play a critical role in T cell antitumor immunity. Cholesterol metabolism is a key component of this response but remains largely unexplored. Herein, we found that the LDL receptor (LDLR), which has been …

Circular RNA circNELL2 Acts as the Sponge of miR-127-5p to Promote Esophageal Squamous Cell Carcinoma Progression Open

Gang Xiong, Dingwei Diao, Di Lu, Xiguang Liu, Zhaoguo Liu , et al. · 2020

circNELL2 promoted the progression of ESCC cells via sponging miR-127-5p, and it has the potential to serve as a novel prognostic and therapeutic target for ESCC.

Clinicopathological features, survival outcomes, and appropriate surgical approaches for stage I acinar and papillary predominant lung adenocarcinoma Open

Di Lu, Jianjun Yang, Xiguang Liu, Siyang Feng, Xiaoying Dong , et al. · 2020

Background Whether prognosis differs between lung acinar predominant adenocarcinoma (ACN) and papillary predominant adenocarcinoma (PAP) patients remains controversial. Furthermore, the appropriate surgical plan for each subtype is undeter…

IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis Open

Xiaoshun Shi, Ruidong Li, Xiaoying Dong, Allen Chen, Xiguang Liu , et al. · 2020

Mapping the Trends in Esophageal Cancer Disease Burden in the United States: Results from the Global Burden of Disease Study 2017 Open

Di Lu, Jintao Zhan, Xiguang Liu, Xiaoying Dong, Siyang Feng , et al. · 2020

Background: Esophageal cancer is the 7th leading cancer globally and the 10th leading cancer in the United States. However, it is has received limited attention over more common malignancies. Only a few studies have comprehensively assesse…

Additional file 8 of IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis Open

Xiaoshun Shi, Ruidong Li, Xiaoying Dong, Allen Chen, Xiguang Liu , et al. · 2020

Additional file 8: Table S5. Significantly enriched immune pathways of gene in the IRGS model.

Additional file 4 of IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis Open

Xiaoshun Shi, Ruidong Li, Xiaoying Dong, Allen Chen, Xiguang Liu , et al. · 2020

Additional file 4: Table S3. Univariate and multivariate analyses of candidate genes for IRGS model development.

Additional file 3 of IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis Open

Xiaoshun Shi, Ruidong Li, Xiaoying Dong, Allen Chen, Xiguang Liu , et al. · 2020

Additional file 3: Table S2. Candidate immune-related genes matched with differentially expressed genes in the TCGA dataset.

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