Shinichiro Nakajima
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View article: Category-Specific Brain Structural Changes in Psychiatric Disorders and Conditions Using Well-Qualified Harmonization Dataset from Multiple Sites
Category-Specific Brain Structural Changes in Psychiatric Disorders and Conditions Using Well-Qualified Harmonization Dataset from Multiple Sites Open
Background Large-scale, multi-site brain magnetic resonance imaging (MRI) studies have revealed neuroanatomical alterations in various psychiatric disorders. However, site-specific differences—such as sampling and measurement biases—and th…
View article: Programming literacy for physician‐scientists in the AI era
Programming literacy for physician‐scientists in the AI era Open
View article: Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution
Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution Open
An accurate diagnostic method using biological indicators is critically needed for bipolar disorder (BD) and major depressive disorder (MDD). The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is…
View article: 221. NEUROMELANIN ACCUMULATION AND TREATMENT RESPONSIVENESS IN PATIENTS WITH SCHIZOPHRENIA: A CROSS-SECTIONAL STUDY WITH NEUROMELANIN-SENSITIVE MRI
221. NEUROMELANIN ACCUMULATION AND TREATMENT RESPONSIVENESS IN PATIENTS WITH SCHIZOPHRENIA: A CROSS-SECTIONAL STUDY WITH NEUROMELANIN-SENSITIVE MRI Open
Background Neuromelanin (NM), a byproduct of monoamine metabolism, reflects dopamine and norepinephrine activity in the brain. NM-sensitive MRI sequences enable in vivo quantification of NM levels in the substantia nigra (SN) and locus coe…
View article: Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays
Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays Open
INTRODUCTION Late‐life mood disorders (LLMDs) may represent prodromal manifestations of neurodegenerative dementia; however, the neuropathological basis of LLMDs, including depression and bipolar disorder, remains unclear. We aimed to inve…
View article: Pleasure in groove is associated with neuromelanin levels in the substantia nigra of younger healthy individuals
Pleasure in groove is associated with neuromelanin levels in the substantia nigra of younger healthy individuals Open
The pleasurable urge to move in response to music is called groove. Prior research has suggested a potential link between groove and dopamine function. However, no studies to date have directly investigated the relationship between the two…
View article: Electroconvulsive Therapy Can Prevent a Worsening of Psychosis and Dystonic Voice in <i>PRKN</i>-associated Parkinson's Disease
Electroconvulsive Therapy Can Prevent a Worsening of Psychosis and Dystonic Voice in <i>PRKN</i>-associated Parkinson's Disease Open
Electroconvulsive therapy (ECT), an established treatment for psychiatric disorders, shows promise in alleviating both motor and non-motor symptoms in patients with Parkinson's disease (PD). We herein report a case of PRKN-associated PD pr…
View article: Associations of Neuromelanin in the Substantia Nigra with Antipsychotic Response in Schizophrenia
Associations of Neuromelanin in the Substantia Nigra with Antipsychotic Response in Schizophrenia Open
Approximately 30% of patients with schizophrenia do not respond to antipsychotics. While schizophrenia has been primarily explained by the dopamine dysfunction hypothesis, treatment-resistant schizophrenia (TRS) may involve a different pat…
View article: Magnetic resonance spectroscopy and the menstrual cycle: A multi-centre assessment of menstrual cycle effects on GABA & GSH
Magnetic resonance spectroscopy and the menstrual cycle: A multi-centre assessment of menstrual cycle effects on GABA & GSH Open
Our findings suggest that the menstrual cycle has minimal impact on MRS measures of GABA and GSH. The presence of a menstrual cycle should not be used as justification for exclusion of women in MRS studies.
View article: MAGNETIC SUBCORTICAL SUSCEPTIBILITY IS ASSOCIATED WITH THE TREATMENT OUTCOME OF REPEATED KETAMINE INFUSION FOR PATIENTS WITH TREATMENT-RESISTANT DEPRESSION
MAGNETIC SUBCORTICAL SUSCEPTIBILITY IS ASSOCIATED WITH THE TREATMENT OUTCOME OF REPEATED KETAMINE INFUSION FOR PATIENTS WITH TREATMENT-RESISTANT DEPRESSION Open
Background Whereas ketamine has displayed robust antidepressant effects in treatment-resistant depression (TRD) (Han et al., 2016), only 30-40% of patients with TRD respond to ketamine therapy (Wilkinson et al., 2018; Sakurai et al., 2020)…
View article: EVALUATION OF NEUROMELANIN IN PATIENTS WITH TREATMENT- RESISTANT SCHIZOPHRENIA
EVALUATION OF NEUROMELANIN IN PATIENTS WITH TREATMENT- RESISTANT SCHIZOPHRENIA Open
Background Approximately 30% of patients with schizophrenia (SZ) do not respond to antipsychotic treatment. Although abnormalities of the dopamine (DA) function are implicated in the pathophysiology of SZ, reports on striatal DA function a…
View article: EFFICACY AND SAFETY OF INTRAVENOUS KETAMINE TREATMENT IN JAPANESE PATIENTS WITH TREATMENT-RESISTANT DEPRESSION: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL
EFFICACY AND SAFETY OF INTRAVENOUS KETAMINE TREATMENT IN JAPANESE PATIENTS WITH TREATMENT-RESISTANT DEPRESSION: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL Open
Background Whereas ketamine's antidepressant effect for treatment-resistant depression (TRD) has been consistent in the literature from the North American and European countries (1-3), its evidence is scarce among the Asian population (4-6…
View article: NEUROANATOMICAL BIOTYPING BY SEMI-SUPERVISED MACHINE LEARNING FOCUSING ON HETEROGENEITY IN TREATMENT-RESISTANT DEPRESSION
NEUROANATOMICAL BIOTYPING BY SEMI-SUPERVISED MACHINE LEARNING FOCUSING ON HETEROGENEITY IN TREATMENT-RESISTANT DEPRESSION Open
Background Treatment-resistant depression (TRD) is a highly biologically heterogeneous disorder, which may be due to underlying neuroanatomical heterogeneity. However, neuroimaging studies to date have not yielded consistent results, possi…
View article: ABNORMAL STRUCTURAL COVARIANCE NETWORK IN TREATMENT- RESISTANT DEPRESSION
ABNORMAL STRUCTURAL COVARIANCE NETWORK IN TREATMENT- RESISTANT DEPRESSION Open
Background Treatment-resistant depression (TRD) is associated with gray matter volume reduction compared to healthy controls (HC). Since depression has increasingly been recognized as a disorder of dysregulated neural networks, it is impor…
View article: ELEVATED INTRINSIC CORTICAL CURVATURE IN TREATMENT-RESISTANT SCHIZOPHRENIA: STRUCTURAL DEFORMATION OF FUNCTIONAL ACTIVITY AREAS
ELEVATED INTRINSIC CORTICAL CURVATURE IN TREATMENT-RESISTANT SCHIZOPHRENIA: STRUCTURAL DEFORMATION OF FUNCTIONAL ACTIVITY AREAS Open
Background Growing research shows abnormal brain structure and connectivity in patients with treatment-resistant schizophrenia (TRS) compared to first-line-responders (TxR) and healthy-controls (HC). While differences are documented as ear…
View article: ACUTE WHITE MATTER INTEGRITY INCREASES AFTER A MODERATE DOSE OF ALCOHOL ADMINISTRATION
ACUTE WHITE MATTER INTEGRITY INCREASES AFTER A MODERATE DOSE OF ALCOHOL ADMINISTRATION Open
Background Chronic heavy alcohol consumption is known to harm health, while occasional light to moderate drinking may have potential benefits. However, it is unclear how modest alcohol intake affects brain structure. Aims & Objectives This…
View article: ASSOCIATIONS BETWEEN NEUROMELANIN ACCUMULATION IN PATIENTS WITH SCHIZOPHRENIA AND TREATMENT RESPONSIVENESS: A CROSS- SECTIONAL NM-MRI STUDY
ASSOCIATIONS BETWEEN NEUROMELANIN ACCUMULATION IN PATIENTS WITH SCHIZOPHRENIA AND TREATMENT RESPONSIVENESS: A CROSS- SECTIONAL NM-MRI STUDY Open
Background Neuromelanin (NM) is a byproduct of monoamine metabolism, including that of dopamine. NM-sensitive Magnetic Resonance Imaging (NM-MRI) sequences enable the in vivo quantification of NM levels in the substantia nigra (SN). The NM…
View article: PREDICTION OF POSTOPERATIVE DELIRIUM BY BLOOD METABOLOME
PREDICTION OF POSTOPERATIVE DELIRIUM BY BLOOD METABOLOME Open
Background Delirium is a notable risk factor for cognitive dysfunction and poor prognosis. Despite its importance, there is currently no established blood marker that can predict postoperative delirium in the preoperative period. Aims & Ob…
View article: DATA-DRIVEN DISEASE PROGRESSION PATTERNS OF BRAIN MORPHOLOGY IN SCHIZOPHRENIA: MORE PROGRESSED STAGES IN TREATMENT- RESISTANCE
DATA-DRIVEN DISEASE PROGRESSION PATTERNS OF BRAIN MORPHOLOGY IN SCHIZOPHRENIA: MORE PROGRESSED STAGES IN TREATMENT- RESISTANCE Open
Background Given the heterogeneity, particularly in terms of treatment response, and possible disease progression in schizophrenia, identifying the neurobiological subtypes and progression patterns in each patient may lead to novel biomark…
View article: AMPA RECEPTOR DENSITY DETERMINES LOCAL AND GLOBAL FUNCTIONAL CONNECTIVITY
AMPA RECEPTOR DENSITY DETERMINES LOCAL AND GLOBAL FUNCTIONAL CONNECTIVITY Open
Background Functional connectivity density, both local (lFCD) and global (gFCD), derived from functional magnetic resonance imaging (fMRI) delineates the prominence of regional and widespread connectivity hubs throughout the brain. However…
View article: Double-blind RCT on the usefulness of QPS therapy for difficult-to-treat depression
Double-blind RCT on the usefulness of QPS therapy for difficult-to-treat depression Open
View article: Effectiveness of sequential bilateral repetitive transcranial stimulation versus bilateral theta burst stimulation for patients with treatment-resistant depression (BEAT-D): A randomized non-inferiority clinical trial
Effectiveness of sequential bilateral repetitive transcranial stimulation versus bilateral theta burst stimulation for patients with treatment-resistant depression (BEAT-D): A randomized non-inferiority clinical trial Open
Our study could not establish the non-inferiority of BL-TBS compared to BL-rTMS in terms of efficacy for patients with TRD across the adult lifespan.
View article: Corrigendum: α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality
Corrigendum: α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality Open
[This corrects the article DOI: 10.3389/fncir.2024.1497897.].
View article: Decreased prefrontal glutamatergic function is associated with a reduced astrocyte-related gene expression in treatment-resistant depression
Decreased prefrontal glutamatergic function is associated with a reduced astrocyte-related gene expression in treatment-resistant depression Open
Glutamatergic dysfunction is involved in the pathophysiology of treatment-resistant depression (TRD). However, few physiological studies have evaluated its pathophysiology in vivo in individuals with TRD. Transcranial magnetic stimulation-…
View article: Increased structural covariance of cortical measures in individuals with an at-risk mental state
Increased structural covariance of cortical measures in individuals with an at-risk mental state Open
An anomalous pattern of structural covariance has been reported in schizophrenia, which has been suggested to represent connectome changes during brain maturation and neuroprogressive processes. It remains unclear whether similar differenc…
View article: α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality
α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality Open
Local and global functional connectivity densities (lFCD and gFCD, respectively), derived from functional magnetic resonance imaging (fMRI) data, represent the degree of functional centrality within local and global brain networks. While t…
View article: Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography
Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography Open
Synaptic phenotypes in living patients with psychiatric disorders are poorly characterized. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a fundamental component for neurotransmission. We re…
View article: Efficacy and safety of intravenous ketamine treatment in Japanese patients with treatment‐resistant depression: A double‐blind, randomized, placebo‐controlled trial
Efficacy and safety of intravenous ketamine treatment in Japanese patients with treatment‐resistant depression: A double‐blind, randomized, placebo‐controlled trial Open
Aim Although the antidepressant effect of ketamine on treatment‐resistant depression (TRD) has been frequently reported in North American and European countries, evidence is scarce among the Asian population. We aimed to evaluate the effic…
View article: A case of painful legs and moving toes syndrome mimicking somatic symptom disorder
A case of painful legs and moving toes syndrome mimicking somatic symptom disorder Open
Painful legs and moving toes syndrome (PLMT) is a rare disorder characterized by pain in one or more lower extremities accompanied by involuntary movements. Since the first case report, subsequent larger cohort studies have refined the sym…
View article: Development of the Japanese version of the Challenging Experience Questionnaire
Development of the Japanese version of the Challenging Experience Questionnaire Open
Introduction The therapeutic potential of psychedelics for various mental disorders has gained significant interest. Previous studies have highlighted that psychedelics induce psychoactive effects, including challenging aspects of experien…