Shin Soyama
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View article: Thrombin Generation Is Associated With Extracellular Vesicle and Leukocyte Lipid Membranes in Atherosclerotic Cardiovascular Disease
Thrombin Generation Is Associated With Extracellular Vesicle and Leukocyte Lipid Membranes in Atherosclerotic Cardiovascular Disease Open
BACKGROUND: Clotting, leading to thrombosis, requires interactions of coagulation factors with the membrane aminophospholipids (aPLs) phosphatidylserine and phosphatidylethanolamine. Atherosclerotic cardiovascular disease (ASCVD) is associ…
View article: Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles: a randomized, controlled crossover trial
Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles: a randomized, controlled crossover trial Open
View article: Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease
Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease Open
Aminophospholipids (aPL) such as phosphatidylserine are essential for supporting the activity of coagulation factors, circulating platelets, and blood cells. Phosphatidylthreonine (PT) is an aminophospholipid previously reported in eukaryo…
View article: Extracellular vesicles from patients with coronary artery disease (CAD) demonstrate enhanced pro-coagulatory activity
Extracellular vesicles from patients with coronary artery disease (CAD) demonstrate enhanced pro-coagulatory activity Open
Aims Extracellular vesicles (EVs) carry unique repertoires of biologically active cargo that hold promise as novel biomarkers and future interventional targets for cardiovascular diseases (CVDs). However, it is unclear as to how the number…
View article: Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in acute coronary syndrome
Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in acute coronary syndrome Open
Background Acute coronary syndrome (ACS) is caused by arterial thrombosis and is associated with sustained activation of coagulation. Clotting requires interactions of coagulation factors with aminophospholipids (aPL): phosphatidylserine (…