Explanipedia

A Case of Appendicitis due to Fish Bone Abscess Formation in the Abdominal Wall Open

Akira Hamada, Makoto Takahashi, Shingo Kawano, Ryosuke Ichikawa, Takashi Yao , et al. · 2024

Assessment of Elastic Laminal Invasion Contributes to an Objective pT3 Subclassification in Colon Cancer Open

Motohiro Kojima, Mitsuru Yokota, Naotake Yanagisawa, Sakiko Kitamura, Kota Amemiya , et al. · 2023

The extent of tumor spread influences on the clinical outcome, and which determine T stage of colorectal cancer. However, pathologic discrimination between pT3 and pT4a in the eighth edition of the American Joint Committee on Cancer (AJCC)…

Local recurrence of submucosal invasive colorectal cancer after endoscopic submucosal dissection revealed by copy number variation Open

Yu Okazawa, Kiichi Sugimoto, Yuki Ii, Takahiro Irie, Megumi Kawaguchi , et al. · 2023

We report a case in which analysis of copy number variation revealed local recurrence of submucosal invasive colorectal cancer after curative endoscopic submucosal dissection (ESD). An 86‐year‐old man with a history of abdominoperineal res…

Benefits and risks of diverting stoma creation during rectal cancer surgery Open

Masaya Kawai, Kazuhiro Sakamoto, Kumpei Honjo, Yu Okazawa, Rina Takahashi , et al. · 2022

Purpose: A consensus has been reached regarding diverting stoma (DS) construction in rectal cancer surgery to avoid reoperation related to anastomotic leakage. However, the incidence of stoma-related complications (SRCs) remains high. In t…

CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer Open

Toshiaki Hagiwara, Kiichi Sugimoto, Hirotaka Momose, Takahiro Irie, Kumpei Honjo , et al. · 2022

We investigated whether promoter methylation of the checkpoint-with-forkhead-and-ring-finger-domains (CHFR) gene is a predictor of the efficacy of irinotecan-based systemic chemotherapy for advanced colorectal cancer (CRC) patients.CHFR-pr…

Application of the Bioabsorbable Polyglycolic Acid Sheet in Colorectal Anastomosis in Animal Models Open

Shingo Kawano, Yutaka Kojima, Yuki Tsuchiya, Shunsuke Motegi, Ryoichi Tsukamoto , et al. · 2022

The bioabsorbable PGA sheet can be used for colorectal DST anastomosis in animal models and may be a valuable tool for this procedure.

Rectal metastasis from bladder urothelial carcinoma: a case report Open

Yuki Ii, Shinya Munakata, Kumpei Honjo, Masaya Kawai, Shingo Kawano , et al. · 2021

A case of simultaneous abdominal wall metastasis of hepatocellular carcinoma with long-term relapse-free survival after laparoscopic resection Open

Michitoshi Goto, Kazuhiro Sakamoto, Shingo Kawano, Shinya Munakata, Masaya Kawai , et al. · 2021

We report our experience of an extremely rare case of a simultaneous extrahepatic metastasis of hepatocellular carcinoma (HCC) with long-term relapse-free survival, treated by laparoscopic resection of an abdominal wall tumor and subsequen…

Diverting Stoma Complications in Rectal Cancer Surgery. Open

Masaya Kawai, Kazuhiro Sakamoto, Kumpei Honjo, Yu Okazawa, Rina Takahashi , et al. · 2021

Background : A consensus regarding diverting stoma (DS) construction in rectal cancer surgery was reached to avoid reoperation related to anastomotic leakage. However, the incidence of stoma-related complications (SRCs) remains high. In th…

A Case of Laparoscopic Wedge Resection of a Schwannoma of the Ascending Colon Diagnosed by Intraoperative Pathological Examination Open

Masahiro Tamura, Shingo Kawano, Shunsuke Motegi, Kumpei Honjo, Masaya Kawai , et al. · 2021

症例は70歳代の女性．近医で潰瘍性大腸炎のため経過観察されていた．下部消化管内視鏡検査を施行したところ，潰瘍性大腸炎は寛解期であったが上行結腸に20mm大の粘膜下腫瘍が認められ，精査加療目的に紹介となった．超音波内視鏡検査では第４層に20mm大の均一な低エコー領域が認められた．造影CT検査では20mm大の造影効果のある腫瘤陰影を上行結腸（肝彎曲部）に認めた．その他，周囲リンパ節腫大や遠隔転移は認められなかった．上行結腸粘膜下腫瘍の鑑別としてGIST，平滑筋腫，神経鞘腫，神経…

Evaluation of Colonic Perfusion for Colorectal Cancer Surgery Using Indocyanine Green Fluorescence Imaging Open

Shunsuke Motegi, Shingo Kawano, Kazuhiro Takehara, Shinya Munakata, Shun Ishiyama , et al. · 2021

Objective: Anastomotic leakage (AL) is one of the most serious postoperative complications in colorectal surgery. AL reportedly occurs in 5-10% of cases following colorectal surgery. Poor colonic perfusion is proceeded to be AL during mese…

Identification of MicroRNA 15b-3p as a Diagnostic Marker for Early Stage of Colorectal Cancer Through Comprehensive RNA Analysis Open

Ryoichi Tsukamoto, Masaki Hosoya, Midori Fukaya, Norihiko Yokoyama, Shingo Kawano , et al. · 2021

Objective Early detection is the key to treatment outcome in colorectal cancer (CRC). This study aimed to identify microRNAs (miRNAs) as a useful diagnostic marker for early-stage CRC.

Serum oxidative stress is an independent prognostic marker in colorectal cancer Open

Kiichi Sugimoto, Kazuhiro Sakamoto, Masaya Kawai, Shingo Kawano, Shinya Munakata , et al. · 2019

Background: Few previous studies have investigated the relationship between serum oxidative stress and the status of patients with colorectal cancer. Our aim in the current study was to investigate the significance of serum oxidative stre…

Serum oxidative stress is an independent prognostic marker in colorectal cancer Open

Kiichi Sugimoto, Kazuhiro Sakamoto, Masaya Kawai, Shingo Kawano, Shinya Munakata , et al. · 2019

The results of this study demonstrate the prognostic value of serum oxidative stress in colorectal cancer.

Colorectal Perforation in Patients with Connective Tissue Disease Open

Kiichi Sugimoto, Kazuhiro Sakamoto, Yu Okazawa, Rina Takahashi, Kosuke Mizukoshi , et al. · 2019

Purpose. The goal of this retrospective study was to identify prognostic factors associated with mortality after surgery for colorectal perforation among patients with connective tissue disease (CTD) and to review postoperative outcomes ba…

Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients Open

Motohiro Kojima, Yu Chen, Koji Ikeda, Yuichiro Tsukada, Daigoro Takahashi , et al. · 2019

The Association between Absence of Abdominal Pain and Mortality in Lower Intestinal Perforation in Patients with Autoimmune Rheumatic Diseases Open

Yukari Endo, Yoshiyuki Abe, Shingo Kawano, Taiki Ando, Kazuhiro Sakamoto , et al. · 2019

Objective . To determine mortality and predictive factors for lower intestinal perforation (LIP) among patients with autoimmune rheumatic diseases. Methods . This retrospective, single-center, observational study analyzed mortality rates i…

Colorectal Adenocarcinoma Occurring in an Indiana Pouch Open

Yuki Tsuchiya, Kota Amemiya, Toshiaki Hagiwara, Hirokazu Matsuzawa, Yurika Makino , et al. · 2018

The patient was an 84-year-old man who had undergone total cystectomy and Indiana pouch construction for bladder cancer in 1989. At the previous hospital in 2017, he was diagnosed with urinary tract infection due to a fever. Abdominal comp…

Endoscopic Submucosal Dissection Decreases Additional Colorectal Resection for T1 Colorectal Cancer Open

Yuichi Tomiki, Masaya Kawai, Shingo Kawano, Shun Ishiyama, Kiichi Sugimoto , et al. · 2018

BACKGROUND There are 3 methods of treating T1 colorectal cancer (T1 CRC), which include endoscopic resection, endoscopic resection followed by additional colorectal resection, and surgical resection. In this retrospective study, changes in…

Repeated laparoscopic resection of extra-regional lymph node metastasis after laparoscopic radical resection for rectal cancer Open

Kazuhiro Sakamoto, Makoto Takahashi, Rina Takahashi, Shingo Kawano, Masaya Kawai , et al. · 2018

Here, we report a case of repeated laparoscopic resection of extra-regional lymph node metastases in a patient after laparoscopic surgery for rectal cancer. A 72-year-old woman was diagnosed with upper rectal cancer and underwent laparosco…

Area of residual tumor is a robust prognostic marker for patients with rectal cancer undergoing preoperative therapy Open

Naoki Sakuyama, Motohiro Kojima, Shingo Kawano, Yoko Matsuda, Mari Mino‐Kenudson , et al. · 2018

The aim of this study was to elucidate differences in the histological features of rectal cancer between patients treated with preoperative chemoradiotherapy and those treated with preoperative chemotherapy. Area of residual tumor ( ART ) …

Transgelin Protein Expression in Colorectal Cancer: A Clinicopathological Study. Open

Kota Amemiya, Motohiro Kojima, Akiko Nagatuma, Shingo Kawano, M Takahashi , et al. · 2018

Transgelin is an actin-binding protein expressed in smooth muscle cells, cancer cells and fibroblasts. While Transgelin has previously been reported to be a tumor suppressor, recent studies have shown that Transgelin is involved in carcino…

Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Incurable Stage IV Colorectal Cancer Open

Shinya Munakata, Kiichi Sugimoto, Kumpei Honjo, Masaya Kawai, Shingo Kawano , et al. · 2018

Objectives: Our aim is investigating the predictive potential of these available and convenient laboratory dates in stage IV colorectal cancer (CRC) patients. Methods: We identified the cases of 114 consecutive patients who underwent the s…

Superior Mesenteric Artery Syndrome Improved by Enteral Nutritional Therapy according to the Controlling Nutritional Status Score Open

Kazuhiro Takehara, Kazuhiro Sakamoto, Rina Takahashi, Masaya Kawai, Shingo Kawano , et al. · 2017

Superior mesenteric artery syndrome (SMAS) is a relatively rare disease that involves bowel obstruction symptoms, such as vomiting and gastric distension, owing to the compression of the third portion of the duodenum from the front by the …

Propensity Score Analysis in the Comparison of Long-Term Outcomes for Locally Advanced Colon Cancer Between Laparoscopic Colectomy and Open Colectomy Open

Kiichi Sugimoto, Kazuhiro Sakamoto, Ryosuke Ichikawa, Kazumasa Kure, Kumpei Honjo , et al. · 2017

Objective: It is difficult to conduct a randomised control trial in a single institution because of the small number of cases. The current study was conducted to investigate if there is any difference in long-term outcome between laparosco…

Minimally Invasive Surgery for Colorectal Cancer Open

Kazuhiro Sakamoto, Ryoichi Tsukamoto, Shingo Kawano, Masaya Kawai, Koichiro Niwa , et al. · 2017

Laparoscopic colectomy was first used for the treatment of colorectal cancer early in the 1990s, before spreading rapidly throughout the world. In comparison with open surgery, laparoscopic colectomy has the advantages of smaller incision,…

A Case of Ileal Perforation Caused by Methotrexate-associated Lymphoproliferative Disorder Open

Shingo Kawano, Masahiro Tamura, Shun Ishiyama, Makoto Takahashi, Michitoshi Goto , et al. · 2017

メトトレキサート（methotrexate:MTX）は，その免疫抑制作用によりリンパ増殖性疾患の発症リスクを増加させる因子として知られている．今回，MTX治療中のリンパ増殖性疾患により，回腸穿孔を発症した症例を経験した．症例は77歳，女性．関節リウマチに対して5年前からMTXを内服していた．急激な腹痛を認め来院した．腹部全体に圧痛および反跳痛を認めた．腹部CTで腹腔内遊離ガス像と腹水を認め，消化管穿孔による汎発性腹膜炎の診断で緊急手術を施行した．腹腔内には混濁した腹水と回腸…

Neuroendocrine Tumors of the Large Intestine: Clinicopathological Features and Predictive Factors of Lymph Node Metastasis Open

Motohiro Kojima, Koji Ikeda, Norio Saito, Naoki Sakuyama, Kenichi Koushi , et al. · 2016

A new histological classification of neuroendocrine tumors (NETs) was established in WHO 2010. ENET and NCCN proposed treatment algorithms for colorectal NET. Retrospective study of NET of the large intestine (colorectal and appendiceal NE…

Histological differences between preoperative chemoradiotherapy and chemotherapy for rectal cancer: a clinicopathological study Open

Naoki Sakuyama, Motohiro Kojima, Shingo Kawano, Tetsuo Akimoto, Norio Saito , et al. · 2016

Pathological studies on the different histological effects between neoadjuvant chemotherapy (NAC) and preoperative chemoradiation therapy (preoperative CRT) have not been performed. The purpose of this study is to elucidate the histologica…

A Case of Residual Rectal Cancer for Ulcerative Colitis Five Years after Ileo-Anal Canal Anastomosis Open

Shingo Kawano, Yurika Makino, Shunsuke Motegi, Kumpei Honjo, Hisashi Ro , et al. · 2016

症例は50歳代の女性で，1985年に潰瘍性大腸炎を発症し内科的治療を継続していた．2009年に直腸S状部癌を認め，大腸全摘・回腸嚢肛門管吻合術を施行された．病理診断はpT2N1M0 pStage IIIaであり，術後補助化学療法としてUFT/LVを6ヵ月間内服した．その後，再発，新規病変の発症なく経過していた．2014年10月，血便，肛門痛が出現し精査の結果，残存直腸に直腸癌を発症しており，腹会陰式直腸回腸嚢切断術を施行した．切除標本では吻合部より肛門側に30×50mm大の…

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