Shingo Nakahata
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View article: Potential of Green-Synthesized Silver Nanoparticles from Herbal Plants as Anticancer Therapy: A Systematic Review of Anticancer Effectiveness
Potential of Green-Synthesized Silver Nanoparticles from Herbal Plants as Anticancer Therapy: A Systematic Review of Anticancer Effectiveness Open
View article: Importance of continuous monitoring of bovine leukaemia virus infection on farms in bovine leukaemia virus‐endemic areas of Japan
Importance of continuous monitoring of bovine leukaemia virus infection on farms in bovine leukaemia virus‐endemic areas of Japan Open
Background Enzootic bovine leukosis (EBL), caused by the bovine leukaemia virus (BLV), has exhibited increasing infection rates in Japan. While many farms implement various infection prevention measures, practical challenges—such as barn s…
View article: Succinic semialdehyde derived from the gut microbiota can promote the proliferation of adult T-cell leukemia/lymphoma cells
Succinic semialdehyde derived from the gut microbiota can promote the proliferation of adult T-cell leukemia/lymphoma cells Open
Adult T-cell leukemia/lymphoma (ATLL) is a refractory blood cancer with severe immunodeficiency resulting from retroviral infection. ATLL develops in only 5 % of HTLV-1-infected individuals, but the entire mechanism of ATLL progression rem…
View article: Complex Role of Regulatory T Cells (Tregs) in the Tumor Microenvironment: Their Molecular Mechanisms and Bidirectional Effects on Cancer Progression
Complex Role of Regulatory T Cells (Tregs) in the Tumor Microenvironment: Their Molecular Mechanisms and Bidirectional Effects on Cancer Progression Open
Regulatory T cells (Tregs) possess unique immunosuppressive activity among CD4-positive T cells. Tregs are ubiquitously present in mammals and function to calm excessive immune responses, thereby suppressing allergies or autoimmune disease…
View article: Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2low Adult T-Cell Leukemia/Lymphoma
Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2low Adult T-Cell Leukemia/Lymphoma Open
N-myc downstream-regulated gene 2 (NDRG2), which is a tumour suppressor, is frequently lost in many types of tumours, including adult T-cell leukaemia/lymphoma (ATL). The downregulation of NDRG2 expression is involved in tumour progression…
View article: Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review
Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review Open
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL). HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host antiviral immunity; however, 5–10% of carriers lose this balance …
View article: Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review
Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review Open
Human T-cell leukemia virus type-1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL). HTLV-1 carriers have a life-long asymptomatic balance between infected cells and host antiviral immunity, but 5–10% of carriers los…
View article: Peripheral T-Cell Lymphoma: From Biological Research to New Therapies
Peripheral T-Cell Lymphoma: From Biological Research to New Therapies Open
This series of six articles (four reviews and two original articles) is presented by international leaders on peripheral T-cell lymphomas (PTCL) [...]
View article: Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity
Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity Open
View article: Identification and tracking of HTLV-1–infected T cell clones in virus-associated neurologic disease
Identification and tracking of HTLV-1–infected T cell clones in virus-associated neurologic disease Open
Human T lymphotropic virus type 1-assoicated (HTLV-1-associated) myelopathy/tropical spastic paraparesis (HAM/TSP) is a neuroinflammatory disease caused by the persistent proliferation of HTLV-1-infected T cells. Here, we performed a T cel…
View article: Supplemental figure legends from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
Supplemental figure legends from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
Supplemental figure legends
View article: Data from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
Data from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
Loss of the tumor suppressor NDRG2 has been implicated in the development of oral squamous cell carcinoma (OSCC), acting by modulating PI3K/AKT-mediated dephosphorylation of PTEN at S380/S382/T383 (STT). Here, we show that the majority of …
View article: Supplemental materials and methods from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
Supplemental materials and methods from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
Sequences of the primers for Reverse-transcription polymerase chain reaction (RT-PCR) and Quantitative real-time PCR analysis
View article: Supplemental figures from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
Supplemental figures from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
Supplemental Figure 1. Keratin staining of cervical lymph nodes from Ndrg2-deficient mice treated with 4-NQO. Supplementary figure related to Figure 2; Supplemental Figure 2. Effect of 4-NQO treatment on an OSCC cell line was observed thro…
View article: supplementary tables from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
supplementary tables from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
supplementary tables: Supplemental Table 1. Expression rates of immunohistochemical staining of NDRG2 versus p-Akt or p-PTEN in tumors from OSCC patients. Supplementary table related to Figure 1; Supplemental Table 2. Incidence of tumour f…
View article: Data from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
Data from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
Loss of the tumor suppressor NDRG2 has been implicated in the development of oral squamous cell carcinoma (OSCC), acting by modulating PI3K/AKT-mediated dephosphorylation of PTEN at S380/S382/T383 (STT). Here, we show that the majority of …
View article: Supplemental figures from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
Supplemental figures from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
Supplemental Figure 1. Keratin staining of cervical lymph nodes from Ndrg2-deficient mice treated with 4-NQO. Supplementary figure related to Figure 2; Supplemental Figure 2. Effect of 4-NQO treatment on an OSCC cell line was observed thro…
View article: Supplemental figure legends from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
Supplemental figure legends from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
Supplemental figure legends
View article: supplementary tables from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
supplementary tables from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
supplementary tables: Supplemental Table 1. Expression rates of immunohistochemical staining of NDRG2 versus p-Akt or p-PTEN in tumors from OSCC patients. Supplementary table related to Figure 1; Supplemental Table 2. Incidence of tumour f…
View article: Supplemental materials and methods from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
Supplemental materials and methods from Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Open
Sequences of the primers for Reverse-transcription polymerase chain reaction (RT-PCR) and Quantitative real-time PCR analysis
View article: Activating Mutation in the Receptor Tyrosine Kinase FLT3 with Clinicopathological Relevance in Canine Mast Cell Tumors
Activating Mutation in the Receptor Tyrosine Kinase FLT3 with Clinicopathological Relevance in Canine Mast Cell Tumors Open
Recent research has focused on the receptor tyrosine kinase (RTK) KIT which is involved in the pathogenesis of canine mast cell tumors (MCT). However, the role of other RTKs in this neoplasm remains unclear. The present study aimed to dete…
View article: RAISING is a high-performance method for identifying random transgene integration sites
RAISING is a high-performance method for identifying random transgene integration sites Open
View article: Antitumor effects of chloroquine/hydroxychloroquine mediated by inhibition of the NF-κB signaling pathway through abrogation of autophagic p47 degradation in adult T-cell leukemia/lymphoma cells
Antitumor effects of chloroquine/hydroxychloroquine mediated by inhibition of the NF-κB signaling pathway through abrogation of autophagic p47 degradation in adult T-cell leukemia/lymphoma cells Open
Adult T-cell leukemia/lymphoma (ATLL) originates from human T-cell leukemia virus type 1 (HTLV-1) infection due to the activation of the nuclear factor-κB (NF-κB) signaling pathway to maintain proliferation and survival. An important mecha…
View article: RAISING: a high-performance method for identifying random transgene integration sites
RAISING: a high-performance method for identifying random transgene integration sites Open
Both natural viral infections and therapeutic interventions using viral vectors pose significant risks of malignant transformation. Monitoring for clonal expansion of infected cells is important for detecting cancer. Here we developed a no…
View article: The role of CD28 in adult T‐cell leukaemia/lymphoma
The role of CD28 in adult T‐cell leukaemia/lymphoma Open
T-cell-specific surface glycoprotein CD28 belongs to the subfamily of costimulatory molecules characterized by an extracellular immunoglobulin variable-like domain. Other members of the subfamily include inducible T-cell costimulator (ICOS…
View article: Pathophysiological significance of N‐myc downstream‐regulated gene 2 in cancer development through protein phosphatase 2A phosphorylation regulation
Pathophysiological significance of N‐myc downstream‐regulated gene 2 in cancer development through protein phosphatase 2A phosphorylation regulation Open
N‐myc downstream‐regulated gene 2 ( NDRG2 ) is a candidate tumor suppressor in various cancers, including adult T‐cell leukemia/lymphoma (ATLL). NDRG2, as a stress‐responsive protein, is induced by several stress‐related signaling pathways…
View article: Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma
Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma Open
Adult T-cell leukemia/leukemia (ATLL) is an aggressive peripheral T-cell malignancy, caused by infection with the human T-cell leukemia virus type 1 (HTLV-1). We have recently shown that cell adhesion molecule 1 (CADM1), a member of the im…
View article: BRD4-Regulated Molecular Targets in Mantle Cell Lymphoma: Insights into Targeted Therapeutic Approach
BRD4-Regulated Molecular Targets in Mantle Cell Lymphoma: Insights into Targeted Therapeutic Approach Open
Concomitant targeting multiple BRD4-regulated molecules may constitute a rational therapeutic strategy for MCL.
View article: Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB
Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB Open
Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, is identified as a novel cell surface marker for human T-cell leukemia virus (HTLV-1)-infected T cells. Adult T-cell leukemia/lymphoma (ATLL) is developed in HTL…
View article: CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis
CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis Open