Shingo Usuki
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View article: MAP7 directs apical cytoskeletal remodeling to establish Sertoli cell polarity and support germ cell development
MAP7 directs apical cytoskeletal remodeling to establish Sertoli cell polarity and support germ cell development Open
Sertoli cells establish a specialized apical domain that organizes the seminiferous epithelium and supports germ cell development, yet how this domain emerges during early postnatal polarization and becomes functionally linked to germ cell…
View article: Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture
Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture Open
Hematopoietic stem cells (HSCs) develop from hemogenic endothelial cells (HECs) during mouse embryogenesis. Understanding the signaling molecules required for HSC development is crucial for the in vitro derivation of HSCs. We previously in…
View article: Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi responses
Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi responses Open
RNA interference (RNAi) is a gene-silencing mechanism triggered by the cytosolic entry of double-stranded RNAs (dsRNAs). Many animal cells internalize extracellular dsRNAs via endocytosis for RNAi induction. However, it is not clear how th…
View article: Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells
Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells Open
Hematopoietic stem cells (HSCs) develop from hemogenic endothelial cells (HECs) in vivo during mouse embryogenesis. When cultured in vitro, cells from the embryo phenotypically defined as pre-HSC-I and pre-HSC-II have the potential to diff…
View article: Multiple myeloma–associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis
Multiple myeloma–associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis Open
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View article: STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells
STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells Open
Meiosis is differently regulated in males and females. In females, germ cells initiate meiosis within a limited time period in the fetal ovary and undergo a prolonged meiotic arrest until puberty. However, how meiosis initiation is coordin…
View article: The role of <i>Zfp352</i> in the regulation of transient expression of 2‐cell specific genes in mouse embryonic stem cells
The role of <i>Zfp352</i> in the regulation of transient expression of 2‐cell specific genes in mouse embryonic stem cells Open
Mouse ES cell populations contain a minor sub‐population that expresses genes specifically expressed in 2‐cell stage embryos. This sub‐population consists of 2‐cell‐gene labeled cells (2CLCs) generated by the transient activation of the 2‐…
View article: Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions
Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions Open
Meiotic prophase progression is differently regulated in males and females. In males, pachytene transition during meiotic prophase is accompanied by robust alteration in gene expression. However, how gene expression is regulated differentl…
View article: A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models
A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models Open
Expansion of CAG and CTG (CWG) triplet repeats causes several inherited neurological diseases. The CWG repeat diseases are thought to involve complex pathogenic mechanisms through expanded CWG repeat-derived RNAs in a noncoding region and …
View article: RNA G-quadruplexes forming scaffolds for α-synuclein aggregation lead to progressive neurodegeneration
RNA G-quadruplexes forming scaffolds for α-synuclein aggregation lead to progressive neurodegeneration Open
Synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, are triggered by the aggregation of α-synuclein, leading to progressive neurodegeneration 1,2,3,4,5,6,7,8 . However, the intracellula…
View article: Supplementary Figure S4 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S4 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S4 shows that KDM5 inhibition of KDM5A knockdown downregulates MYC target genes in MM.
View article: Supplementary Figure S3 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S3 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S3 shows that JQKD82 have good activities against KDM5 in MM cells and in animal models.
View article: Supplementary Figure S3 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S3 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S3 shows that JQKD82 have good activities against KDM5 in MM cells and in animal models.
View article: Supplementary Table S2 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Table S2 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Table S2 shows the ChIP-seq data with the peaks significantly overlap with KDM5A ChIP-seq peaks MM1S
View article: Supplementary Figure S1 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S1 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S1 shows that higher KDM5A expression is associated with poor prognosis in MM.
View article: Supplementary Figure S6 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S6 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S6 shows that genome-wide H3K4me3 and RNAPII changes after treatment with JQKD82 or knockdown of KDM5A in MM.1S cells
View article: Supplementary Figure S6 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S6 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S6 shows that genome-wide H3K4me3 and RNAPII changes after treatment with JQKD82 or knockdown of KDM5A in MM.1S cells
View article: Data from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Data from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Lysine demethylase 5A (KDM5A) is a negative regulator of histone H3 lysine 4 trimethylation (H3K4me3), a histone mark associated with activate gene transcription. We identify that KDM5A interacts with the P-TEFb complex and cooperates wit…
View article: Data from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Data from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Lysine demethylase 5A (KDM5A) is a negative regulator of histone H3 lysine 4 trimethylation (H3K4me3), a histone mark associated with activate gene transcription. We identify that KDM5A interacts with the P-TEFb complex and cooperates wit…
View article: Supplementary Table S3 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Table S3 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary table S3 listed the potential KDM5A binding proteins identified by mass spectrometry.
View article: Supplementary Method from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Method from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Methods, compound synthesis, Supplementary Materials and Supplementary References
View article: Supplementary Figure S2 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S2 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S2 shows the selectivity of JQKD82 against KDM5 in biochemical assay and in MM cells
View article: Supplementary Method from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Method from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Methods, compound synthesis, Supplementary Materials and Supplementary References
View article: Supplementary Figure S5 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S5 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S5 shows the genome-wide localization of KDM5A in MM.1S cells.
View article: Supplementary Table S2 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Table S2 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Table S2 shows the ChIP-seq data with the peaks significantly overlap with KDM5A ChIP-seq peaks MM1S
View article: Supplementary Figure S4 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Supplementary Figure S4 from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma Open
Supplementary Figure S4 shows that KDM5 inhibition of KDM5A knockdown downregulates MYC target genes in MM.