Explanipedia

Utility of the Base Editing System for Introducing Drug-Resistant Gene Mutations Into Human Leukemia Cellular Models Open

Thao Nguyen, Minori Tamai, Shinichi Fujisawa, Akiko Nagamachi, Keiko Kagami , et al. · 2025

Issue Information Open

Marc A. Pfeffer, Koen Martens, Thomas Kartika, Hannah Stowe McMurry, Steven T. Olson , et al. · 2023

Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia

Factors associated with household transmission of SARS‐CoV‐2 omicron variant to health care workers: A retrospective cohort study Open

Keisuke Kagami, Reiko Oyamada, Tsubasa Watanabe, Sho Nakakubo, Takahiro Hayashi , et al. · 2023

Aim The aim of this study was to determine the risk factors for household transmission of the omicron variant of SARS‐CoV‐2. Background The household infection rate has been reported to be higher for the omicron variant than for non‐omicro…

SARS-CoV-2 Omicron detection by antigen tests using saliva Open

Kaoru Murakami, Sumio Iwasaki, Satoshi Oguri, Kumiko Tanaka, Rigel Suzuki , et al. · 2022

Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis Open

Minori Tamai, Shinichi Fujisawa, Thao Nguyen, Chiaki Komatsu, Keiko Kagami , et al. · 2022

The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the BCR gene located on chromosome 9q34 and the ABL1 ge…

Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis Open

Minori Tamai, Shinichi Fujisawa, Thao Nguyen, Chiaki Komatsu, Keiko Kagami , et al. · 2022

The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the BCR gene located on chromosome 9q34 and the ABL1 ge…

SARS-CoV-2 Omicron Detection by Antigen Tests Using Saliva Open

Kaoru Murakami, Sumio Iwasaki, Satoshi Oguri, Kumiko Tanaka, Rigel Suzuki , et al. · 2022

Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript Open

Naoki Miyashita, Masahiro Onozawa, Keito Suto, Shinichi Fujisawa, Nanase Okazaki , et al. · 2021

Right neck swelling and pain occurred in a 49-year-old man. A Blood count showed a slight increase in platelet count without leukemoid reaction. After a biopsy of the cervical mass and bone marrow aspiration, a diagnosis of extramedullary …

Performance of Qualitative and Quantitative Antigen Tests for SARS-CoV-2 Using Saliva Open

Isao Yokota, Takayo Sakurazawa, Junichi Sugita, Sumio Iwasaki, Keiko Yasuda , et al. · 2021

The rapid detection of SARS-CoV-2 is critical for the prevention of disease outbreaks. Antigen tests such as immunochromatographic assay (ICA) and chemiluminescent enzyme immunoassay (CLEIA) can yield results more quickly than PCR. We eval…

A novel strategy for SARS-CoV-2 mass screening with quantitative antigen testing of saliva: a diagnostic accuracy study Open

Isao Yokota, Peter Y. Shane, Kazufumi Okada, Yoko Unoki, Yichi Yang , et al. · 2021

Ministry of Health, Labour and Welfare, Japan.

Effect of varying storage conditions on diagnostic test outcomes of SARS-CoV-2 Open

Satoshi Oguri, Shinichi Fujisawa, Keisuke Kamada, Sho Nakakubo, Yu Yamashita , et al. · 2021

Equivalent SARS-CoV-2 viral loads by PCR between nasopharyngeal swab and saliva in symptomatic patients Open

Isao Yokota, Takeshi Hattori, Peter Y. Shane, Satoshi Konno, Atsushi Nagasaka , et al. · 2021

Emerging evidences have shown the utility of saliva for the detection of SARS-CoV-2 by PCR as alternative to nasopharyngeal swab (NPS). However, conflicting results have been reported regarding viral loads between NPS and saliva. We conduc…

Myelomonocytic differentiation of leukemic blasts accompanied by differentiation syndrome in a case of <i>FLT3</i>-ITD-positive AML treated with gilteritinib Open

Takeshi Kondo, Masahiro Onozawa, Shinichi Fujisawa, Shinpei Harada, Reiki Ogasawara , et al. · 2021

Fms-like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes in acute myelogenous leukemia (AML) and the mutation is associated with poor prognosis of patients. Two distinct types of activating mutations have been i…

Performance of qualitative and quantitative antigen tests for SARS-CoV-2 in early symptomatic patients using saliva Open

Isao Yokota, Takayo Sakurazawa, Junichi Sugita, Sumio Iwasaki, Keiko Yasuda , et al. · 2020

Background The rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent need for the prevention and containment of disease outbreaks in communities. Although the gold standard is polymerase chain reactio…

SARS-CoV-2 detection by fluorescence loop-mediated isothermal amplification with and without RNA extraction Open

Keisuke Taki, Isao Yokota, Tatsuya Fukumoto, Sumio Iwasaki, Shinichi Fujisawa , et al. · 2020

Mass Screening of Asymptomatic Persons for Severe Acute Respiratory Syndrome Coronavirus 2 Using Saliva Open

Isao Yokota, Peter Y. Shane, Kazufumi Okada, Yoko Unoki, Yichi Yang , et al. · 2020

Background Coronavirus disease 2019 (COVID-19) has rapidly evolved to become a global pandemic, largely owing to the transmission of its causative virus through asymptomatic carriers. Detection of severe acute respiratory syndrome coronavi…

Equivalent SARS-CoV-2 viral loads between nasopharyngeal swab and saliva in symptomatic patients Open

Isao Yokota, Takeshi Hattori, Peter Y. Shane, Satoshi Konno, Atsushi Nagasaka , et al. · 2020

COVID-19 is diagnosed by detecting SARS-CoV-2 by nasopharyngeal swab (NPS) using real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Emerging evidences have shown the utility of saliva, although conflicting re…

Mass screening of asymptomatic persons for SARS-CoV-2 using saliva Open

Isao Yokota, Peter Y. Shane, Kazufumi Okada, Yoko Unoki, Yichi Yang , et al. · 2020

Background COVID-19 has rapidly evolved to become a global pandemic due largely to the transmission of its causative virus through asymptomatic carriers. Detection of SARS-CoV-2 in asymptomatic people is an urgent priority for the preventi…

Efficacy of a novel SARS-CoV-2 detection kit without RNA extraction and purification Open

Tatsuya Fukumoto, Sumio Iwasaki, Shinichi Fujisawa, Kasumi Hayasaka, Kaori Sato , et al. · 2020

Rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the diagnosis of coronavirus disease 2019 (COVID-19) and preventing the spread of the virus. A novel detection kit - the 2019 Novel Coronavirus…

Older age is associated with sustained detection of SARS-CoV-2 in nasopharyngeal swab samples Open

Takeshi Hattori, Masaru Amishima, Daisuke Morinaga, Keisuke Kamada, Sho Nakakubo , et al. · 2020

Comparison of SARS-CoV-2 detection in nasopharyngeal swab and saliva Open

Sumio Iwasaki, Shinichi Fujisawa, Sho Nakakubo, Keisuke Kamada, Yu Yamashita , et al. · 2020

Efficacy of a novel SARS-CoV-2 detection kit without RNA extraction and purification Open

Tatsuya Fukumoto, Sumio Iwasaki, Shinichi Fujisawa, Kasumi Hayasaka, Kaori Sato , et al. · 2020

Rapid detection of SARS-CoV-2 is critical for the diagnosis of coronavirus disease 2019 (COVID-19) and preventing the spread of the virus. A novel “2019 Novel Coronavirus Detection Kit (nCoV-DK)” halves detection time by eliminating the st…

Older age is associated with sustained detection of SARS-CoV-2 in nasopharyngeal swab samples Open

Takeshi Hattori, Masaru Amishima, Daisuke Morinaga, Keisuke Kamada, Sho Nakakubo , et al. · 2020

PCR testing of nasopharyngeal swab samples is used for the diagnosis of coronavirus disease 2019 (COVID-19) and for determining timing of discharge. The viral load usually declines at convalescent phase, but sometimes remained positive for…

Comparison of SARS-CoV-2 detection in nasopharyngeal swab and saliva Open

Sumio Iwasaki, Shinichi Fujisawa, Sho Nakakubo, Keisuke Kamada, Yu Yamashita , et al. · 2020

We prospectively compared the efficacy of PCR detection of SARS-CoV-2 between paired nasopharyngeal and saliva samples in 76 patients including ten COVID-19 patients. The overall concordance rate of the virus detection between the two samp…

A Novel Strategy for SARS-CoV-2 Mass-Screening Using Quantitative Antigen Testing of Saliva Open

Isao Yokota, Peter Y. Shane, Kazufumi Okada, Yokota Unoki, Yichi Yang , et al. · 2020

Mass Screening of Asymptomatic Persons for SARS-CoV-2 Using Saliva Open

Isao Yokota, Peter Y. Shane, Kazufumi Okada, Yokota Unoki, Yichi Yang , et al. · 2020

Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia: A Hokkaido Leukemia Net Study Open

Daisuke Hidaka, Masahiro Onozawa, Junichi Hashiguchi, Naohiro Miyashita, Kohei Kasahara , et al. · 2018

Development of a Fluorescence in Situ Hybridization Probe for Detecting IKZF1 Deletion Mutations in Patients with Acute Lymphoblastic Leukemia Open

Junichi Hashiguchi, Masahiro Onozawa, Satoshi Oguri, Shinichi Fujisawa, Masahisa Tsuji , et al. · 2018

Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy Open

Kohei Kasahara, Masahiro Onozawa, Naohiro Miyashita, Emi Yokohata, Miho Yoshida , et al. · 2016

We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q…

Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients Open

Yoshihiko Shibayama, Takeshi Kondo, Hiroki Ohya, Shinichi Fujisawa, Takanori Teshima , et al. · 2015

MicroRNAs (miRs) have been shown to negatively regulate gene expression by binding to mRNAs, and they play an important role in various physiological processes and malignancies. A previous study identified mature miR-126-3p as an onco-micr…

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