Shinjiro Hamano
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View article: Association between Schistosoma mansoni infection and fecal occult blood in schoolchildren in Mbita, Suba North Sub-County, western Kenya
Association between Schistosoma mansoni infection and fecal occult blood in schoolchildren in Mbita, Suba North Sub-County, western Kenya Open
Fecal occult blood (FOB) is a reliable indicator of bowel morbidity, yet its utility in the context of intestinal schistosomiasis remains inadequately characterized. To address this gap, we conducted a pre-post intervention study to evalua…
View article: Protocol for identifying immune mediators during Leishmania infection in mice using metabolomic analysis
Protocol for identifying immune mediators during Leishmania infection in mice using metabolomic analysis Open
Here, we present a protocol for identifying immune mediators during Leishmania infection in mice using metabolomic analysis. We describe steps for Leishmania infection, harvesting infected tissues, and performing liquid chromatography-mass…
View article: Closing the diagnostic gap in male genital schistosomiasis (MGS): current detection tools and novel strategies
Closing the diagnostic gap in male genital schistosomiasis (MGS): current detection tools and novel strategies Open
Male genital schistosomiasis (MGS), a gender-specific manifestation of urogenital schistosomiasis and neglected tropical disease, typically results from the entrapment of Schistosoma haematobium eggs within the male genital tract. Across t…
View article: LmCen−/− based vaccine is protective against canine visceral leishmaniasis following three natural exposures in Tunisia
LmCen−/− based vaccine is protective against canine visceral leishmaniasis following three natural exposures in Tunisia Open
Dogs are the main reservoir host of Leishmania infantum, etiological agent of zoonotic visceral leishmaniasis (ZVL). An effective vaccine against Canine Visceral Leishmaniasis (CVL) will help the control and elimination of ZVL. In this stu…
View article: Development of tolerance to bedaquiline by overexpression of trypanosomal acetate: succinate CoA transferase in Mycobacterium smegmatis
Development of tolerance to bedaquiline by overexpression of trypanosomal acetate: succinate CoA transferase in Mycobacterium smegmatis Open
View article: Detection and analysis of Serpin and RP26 specific antibodies for monitoring Schistosoma haematobium transmission
Detection and analysis of Serpin and RP26 specific antibodies for monitoring Schistosoma haematobium transmission Open
Background Schistosoma haematobium is the causative pathogen for urogenital schistosomiasis. To achieve progress towards schistosomiasis elimination, there is a critical need for developing highly sensitive and specific tools to monitor tr…
View article: Natural Reservoir of Trypanosoma cruzi Found in Triatomines Targeting Humans: Results from Nation-wide Vector Surveillance in El Salvador
Natural Reservoir of Trypanosoma cruzi Found in Triatomines Targeting Humans: Results from Nation-wide Vector Surveillance in El Salvador Open
In this study, a holistic understanding of the feeding patterns of T. cruzi-positive T. dimidiata in El Salvador is dated. The detection of human DNA in the midgut contents of T. dimidiata indicated the possibility of …
View article: Downregulation of IRF7-mediated type-I interferon response by LmCen–/– parasites is necessary for protective immunity
Downregulation of IRF7-mediated type-I interferon response by LmCen–/– parasites is necessary for protective immunity Open
View article: Repeated versus single praziquantel dosing regimen in treatment of female genital schistosomiasis: a phase 2 randomised controlled trial showing no difference in efficacy
Repeated versus single praziquantel dosing regimen in treatment of female genital schistosomiasis: a phase 2 randomised controlled trial showing no difference in efficacy Open
Background Single-dose praziquantel (PZQ) for treating urogenital schistosomiasis has been reported as inadequate for achieving significant resolution of female genital schistosomiasis (FGS)-associated cervicovaginal lesions. This randomis…
View article: An assessment of gynecological manifestations in women with female genital schistosomiasis with reference to Schistosoma biomarkers, sexually transmitted infections and bacterial vaginosis
An assessment of gynecological manifestations in women with female genital schistosomiasis with reference to Schistosoma biomarkers, sexually transmitted infections and bacterial vaginosis Open
Background Although a variety of different gynecological manifestations have been reported in women with female genital schistosomiasis (FGS), causality remains to be established. This study aimed to evaluate the gynecological manifestatio…
View article: Astrophysical calibration of the oscillator strengths of <i>YJ</i>-band absorption lines in classical Cepheids
Astrophysical calibration of the oscillator strengths of <i>YJ</i>-band absorption lines in classical Cepheids Open
Newly-developed spectrographs with increased resolving powers, particularly those covering the near-IR range, allow the characterization of more and more absorption lines in stellar spectra. This includes the identification and confirmatio…
View article: Barriers and misconceptions hindering reduction of intestinal schistosomiasis in Mbita Sub-County, Western Kenya
Barriers and misconceptions hindering reduction of intestinal schistosomiasis in Mbita Sub-County, Western Kenya Open
View article: Barriers and Misconceptions Hindering Reduction of Intestinal Schistosomiasis in Mbita Sub-County, Western Kenya
Barriers and Misconceptions Hindering Reduction of Intestinal Schistosomiasis in Mbita Sub-County, Western Kenya Open
Background Community and individual participation are crucial for the success of schistosomiasis control. The World Health Organization (WHO) has highlighted the importance of enhanced sanitation, health education, and mass treatment in th…
View article: Association between diet quality and risk of stunting among school-aged children in Schistosoma mansoni endemic area of western Kenya: a cross-sectional study
Association between diet quality and risk of stunting among school-aged children in Schistosoma mansoni endemic area of western Kenya: a cross-sectional study Open
View article: Production of leishmanin skin test antigen from Leishmania donovani for future reintroduction in the field
Production of leishmanin skin test antigen from Leishmania donovani for future reintroduction in the field Open
View article: In vitro evaluation of the effect of galectins on Schistosoma mansoni motility
In vitro evaluation of the effect of galectins on Schistosoma mansoni motility Open
View article: Leishmania mexicana centrin knockout parasites promote M1-polarizing metabolic changes
Leishmania mexicana centrin knockout parasites promote M1-polarizing metabolic changes Open
View article: Leishmania major centrin knock-out parasites reprogram tryptophan metabolism to induce a pro-inflammatory response
Leishmania major centrin knock-out parasites reprogram tryptophan metabolism to induce a pro-inflammatory response Open
View article: Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents
Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents Open
Background Current therapeutic agents, including nifurtimox and benznidazole, are not sufficiently effective in the chronic phase of Trypanosoma cruzi infection and are accompanied by various side effects. In this study, 120 kinds of extra…
View article: Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis
Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis Open
View article: Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes
Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes Open
Disease manifestations of cutaneous leishmaniasis (CL) range from self-healing cutaneous lesions to chronic forms of the disease, depending on the infecting Leishmania sp. and host immune protection. Previous works on mouse models of CL sh…
View article: <i>Leishmania major centrin</i>knock-out parasites alter the kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory response
<i>Leishmania major centrin</i>knock-out parasites alter the kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory response Open
Summary Leishmaniasis is a parasitic disease that is prevalent in approximately 88 countries, and yet no licensed human vaccine exists against it. Towards control of leishmaniasis, we have developed Leishmania major centrin gene deletion m…
View article: Schistosoma mansoni larvae in vitro cultures using Biomphalaria glabrata extracts
Schistosoma mansoni larvae in vitro cultures using Biomphalaria glabrata extracts Open
Schistosomiasis is one of the most prevalent waterborne parasitic diseases affecting humans. In natural conditions, snails are necessary for maintenance of its lifecycle and also required as intermediate hosts to maintain the lifecycle in …
View article: Centrin-deficient <i>Leishmania mexicana</i> confers protection against Old World visceral leishmaniasis
Centrin-deficient <i>Leishmania mexicana</i> confers protection against Old World visceral leishmaniasis Open
Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this disease is also spreading in the developed world. Currently, there is a lack of e…
View article: Acute-phase Serum Cytokine Levels and Correlation with Clinical Outcomes in Children and Adults with Primary and Secondary Dengue Virus Infection in Myanmar between 2017 and 2019
Acute-phase Serum Cytokine Levels and Correlation with Clinical Outcomes in Children and Adults with Primary and Secondary Dengue Virus Infection in Myanmar between 2017 and 2019 Open
The dengue virus (DENV) has been endemic in Myanmar since 1970, causing outbreaks every 2–3 years. DENV infection symptoms range from mild fever to lethal hemorrhage. Clinical biomarkers must be identified to facilitate patient risk strati…
View article: Leishmania Major Centrin Gene-Deleted Parasites Generate Skin Resident Memory T-Cell Immune Response Analogous to Leishmanization
Leishmania Major Centrin Gene-Deleted Parasites Generate Skin Resident Memory T-Cell Immune Response Analogous to Leishmanization Open
Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed a live attenuated Leishmania major centrin gene-deleted parasite strain ( LmCen …
View article: Correction: Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel
Correction: Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel Open
[This corrects the article DOI: 10.1371/journal.pntd.0008518.].
View article: Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis
Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis Open
Leishmaniasis is a neglected protozoan disease affecting over 12 million people globally with no approved vaccines for human use. New World cutaneous leishmaniasis (CL) caused by L. mexicana is characterized by the development of chronic n…
View article: Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanization
Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanization Open
Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed a live attenuated Leishmania major centrin gene deleted parasite strain ( LmCen …
View article: <i>Entamoeba</i> Chitinase is Required for Mature Round Cyst Formation
<i>Entamoeba</i> Chitinase is Required for Mature Round Cyst Formation Open
Amoebiasis is caused by Entamoeba histolytica infection and is transmitted by dormant Entamoeba cells or cysts. Cysts need to be tolerant to severe environmental stresses faced outside and inside a human host.