Explanipedia

ANALYSIS OF LET PROFILES AND TREATMENT OUTCOMES OF PANCREATIC CANCER TREATED WITH CARBON ION RADIOTHERAPY Open

Soichiro Sakamoto, Makoto Sakai, Masahiko Okamoto, Shintaro Shiba, Hanae Yoshida , et al. · 2025

Impact of four-dimensional computed tomography phase number on target coverage of four-dimensional robustly optimized lung stereotactic body radiotherapy Open

Takayuki Yagihashi, Tatsuya Inoue, Masashi Yamanaka, Shintaro Shiba, Akihiro Yamano , et al. · 2025

This study evaluated the dosimetric benefits of various four-dimensional (4D) robust optimization strategies for enhancing plan robustness in free-breathing stereotactic body radiotherapy (SBRT). For ten early-stage lung cancer patients, w…

Development of a Real-Time Dose Calculation Method for BNCT Based on Blood Boron Concentration Open

Tetsuo Yagihashi, Masashi Yamanaka, Shintaro Shiba, K. Matsumoto, Koh‐hei Nitta , et al. · 2025

Initial Experience With Proton Beam Therapy for Pancreatic Cancer at Shonan Kamakura General Hospital Open

Shintaro Shiba, Sachika Shiraishi, K Koizumi, Yutaka Fujimoto, Naoto Ishiai , et al. · 2025

The clinical outcomes at the newly established PBT facility were comparable and reproducible to those observed in patients treated under the previous advanced medical treatment system.

ECM-Preserving Decellularization of Dermis via Subtle Cell Membrane Disruption Induced by Subcritical Dimethyl Ether Open

Naoko Nakamura, Kazushige Tanabe, Hirofumi FUKUHARA, Kohei Otsuki, M. Shimotomai , et al. · 2025

Decellularized tissues are used as biomaterials for transplantation. Many decellularized tissues in clinical applications are prepared using surfactants; however, we have developed a new decellularization method that uses subcritical dimet…

Low Dose-Averaged Linear Energy Transfer Contributes to Local Recurrence of Pancreatic Cancer Treated With Carbon Ion Radiation Therapy Open

Soichiro Sakamoto, Takahiro Oike, Daijiro Kobayashi, Yuhei Miyasaka, Makoto Sakai , et al. · 2025

This is the largest study investigating the association between tumor LET_d profiles and LC post-CIRT. The results suggest that low LET_d within the CTV is associated with poor LC in patients with pancreatic cancer trea…

Neutron capture-enhanced proton beam therapy outside the irradiation field: in vitro experiments Open

Shintaro Shiba, Takahiro Shimo, Masashi YAMANAKA, Kazuki Matsumoto, Akihiro Yamano , et al. · 2025

Objective To evaluate the cell-killing effects of neutron capture-enhanced particle therapy (NCEPT) outside the proton beam irradiation (PBI) field. Results Human osteosarcoma cells (MG63) were divided into control and NCEPT groups. Four h…

Long-term Efficacy and Safety of Carbon-ion Radiotherapy for Thoracic Chordoma: A Case Report Open

Daisuke Irie, Shintaro Shiba, Yuhei Miyasaka, Masahiko Okamoto, Yasuhiro Yoshimatsu , et al. · 2025

We observed a favourable local response with manageable toxicity in a patient with thoracic chordoma treated with C-ion RT. Although this is a single-case report, our findings suggest that C-ion RT could be considered a viable treatment op…

Investigating the Secondary Thermal Neutron Intensity of Neutron Capture-Enhanced Proton Therapy Open

Takahiro Shimo, Shintaro Shiba, Hiroyuki Watanabe, Masashi YAMANAKA, Kazuki Matsumoto , et al. · 2025

This study aimed to investigate the distribution of thermal neutron fluence generated during proton-beam therapy (PBT) scanning, focusing on neutrons produced within the body using Monte Carlo simulations (MCSs). MCSs used the Particle and…

Carbon-Ion Radiotherapy as a Local Treatment Option for Hepatocellular Carcinoma With Child-Pugh Class B Cirrhosis Open

Shintaro Shiba, Keisuke Tsuchida, Nobutaka Mizoguchi, Shohei Kawashiro, Satoshi Shima , et al. · 2025

Spot Scanning Proton Beam Therapy for Surgery-inaccessible Hepatocellular Carcinoma: Preliminary Results Open

Yutaka Fujimoto, Sachika Shiraishi, Masashi YAMANAKA, Akihiro Yamano, Kazuki Matsumoto , et al. · 2025

SS-PBT shows promise as a treatment option for surgery-inaccessible hepatocellular carcinoma.

Simultaneous Motion And Noise Estimation with Event Cameras Open

Shintaro Shiba, Guillermo Gallego · 2025

Event cameras are emerging vision sensors whose noise is challenging to characterize. Existing denoising methods for event cameras are often designed in isolation and thus consider other tasks, such as motion estimation, separately (i.e., …

Lumbosacral Plexopathy After Carbon-ion Radiation Therapy for Postoperative Pelvic Recurrence of Rectal Cancer: Subanalysis of a Prospective Observational Study (GUNMA 0801) Open

Takuya Kumazawa, Shintaro Shiba, Yuhei Miyasaka, Masahiko Okamoto, Daijiro Kobayashi , et al. · 2025

Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients Open

S. Suzuki, Shintaro Shiba, Hiroki Tanaka, Masashi YAMANAKA, Kazuki Matsumoto , et al. · 2025

BNCT had a significantly lower LAR compared to PBT and XT. These findings suggest the usefulness of BNCT in pediatric and AYA patients with brain tumors from the perspective of post-irradiation secondary cancer.

Evaluation of the Mini-ridge Filter’s Impact on the Generation of Secondary Radiation in Synchrotron-based Proton Beam Therapy Open

Takahiro Shimo, Shintaro Shiba, Hiroyuki Watanabe, Masashi YAMANAKA, Kazuki Matsumoto , et al. · 2025

Purpose: This study evaluated whether the mini-ridge filter (MRF) used for beam energy optimization in a synchrotron-based proton beam therapy (PBT) affects the generation of secondary neutrons and photons. Materials and Methods: Secondary…

Increased cell killing effect in neutron capture enhanced proton beam therapy Open

Shintaro Shiba, Takahiro Shimo, Masashi YAMANAKA, Takayuki Yagihashi, Makoto Sakai , et al. · 2024

Thermal neutrons generated in the body during proton beam therapy (PBT) can be used to cause boron neutron capture reactions and have recently been proposed as neutron capture enhanced PBT (NCEPBT). However, the cell killing effect of NCEP…

Dosimetric Evaluation of Beam-specific PTV and Worst-case Optimization Methods for Liver Proton Therapy Open

Akihiro Yamano, Tatsuya Inoue, Shintaro Shiba, Takahiro Shimo, Masashi YAMANAKA , et al. · 2024

In SFUD proton therapy for liver cancer, the WCO plans required a longer optimization time but exhibited superior robustness in GTV coverage and sparing of OARs.

FUNDAMENTAL MEASUREMENT OF SOFT ERRORS IN ELECTRONIC DEVICES EXPOSED TO NEUTRONS IN BNCT Open

Takayuki Yagihashi, Shintaro Shiba, Makoto Sakai, Yudai Kawakami, Reika Imazu , et al. · 2024

Evaluating optimal quality assurance and quality control conditions of activation measurements at the accelerator-based boron neutron capture therapy system employing a lithium target Open

S. Suzuki, Takayuki Yagihashi, Kazunori Nitta, Masashi Yamanaka, Naoki Sato , et al. · 2024

Evaluating neutron output is important to ensure proper dose delivery for patients in boron neutron capture therapy (BNCT). It requires efficient quality assurance (QA) and quality control (QC) while maintaining measurement accuracy. This …

Cost-Effectiveness Comparison of Carbon-Ion Radiation Therapy and Transarterial Chemoembolization for Hepatocellular Carcinoma Open

Shohei Okazaki, Kei Shibuya, Shintaro Shiba, Tomoyuki Takura, Tatsuya Ohno · 2024

Proton-beam Therapy for Locally Advanced Hepatocellular Carcinoma With Inferior Vena Cava Tumor Thrombus: Case Report Open

Shintaro Shiba, Sachika Shiraishi, Koichi Tokuuye, Ryosuke Shirata, Motoko Omura · 2024

We observed a favorable local response with manageable toxicities in a patient with locally advanced HCC and IVCTT treated with PBT. While this is a single case report, our findings suggest that PBT could be considered a viable treatment o…

Comparing Efficacy Between Robust and PTV Margin-based Optimizations for Interfractional Anatomical Variations in Prostate Tomotherapy Open

Takayuki Yagihashi, Tatsuya Inoue, Shintaro Shiba, Akihiro Yamano, Masashi YAMANAKA , et al. · 2023

Robust optimization is recommended as it accounts for anatomical variations during treatment regarding target coverage in helical tomotherapy plans for prostate cancer.

Five-year outcomes in carbon-ion radiotherapy for postoperative pelvic recurrence of rectal cancer: A prospective clinical trial (GUNMA 0801) Open

Shintaro Shiba, Masahiko Okamoto, Kei Shibuya, Daijiro Kobayashi, Yuhei Miyasaka , et al. · 2023

Dose Distribution Degradation of Carbon-ion Radiotherapy Caused by Tumor Cell-specific Relative Biological Effectiveness of Osteosarcoma: A Simulation Study Using<i>In Vitro</i>Experimental Results Open

Shintaro Shiba, Motohiro Kawashima, Masahiko Okamoto, Tatsuya Ohno · 2023

We utilized RBE_U2OS to calculate the dose distribution of carbon ion radiotherapy, revealing potential degradation in dose distribution and particularly worsening of the HI.

Impact of delivery time factor on treatment time and plan quality in tomotherapy Open

Takayuki Yagihashi, Tatsuya Inoue, Shintaro Shiba, Akihiro Yamano, Yumiko Minagawa , et al. · 2023

Delivery time factor (DTF) is a new parameter introduced by the RayStation treatment planning system for tomotherapy treatment planning. This study investigated the effects of this factor on various tomotherapy plans. Twenty-five patients …

Carbon‐ion radiotherapy for oligometastatic liver disease: A national multicentric study by the Japan Carbon‐Ion Radiation Oncology Study Group (J‐CROS) Open

Shintaro Shiba, Masaru Wakatsuki, Shingo Toyama, Kazuki Terashima, Hirofumi Uchida , et al. · 2023

Reports on the therapeutic efficacy and safety of carbon‐ion radiotherapy (C‐ion RT) for oligometastatic liver disease are limited, with insufficient evidence. This study aimed to evaluate the clinical outcomes of C‐ion RT for oligometasta…

Carbon-Ion Radiotherapy Combined with Concurrent Chemotherapy for Locally Advanced Pancreatic Cancer: A Retrospective Case Series Analysis Open

Masahiko Okamoto, Shintaro Shiba, Daijiro Kobayashi, Yuhei Miyasaka, Shohei Okazaki , et al. · 2023

Systemic chemotherapy has significantly improved in recent years. In this study. the clinical impact of carbon-ion radiotherapy (CIRT) with concurrent chemotherapy for locally advanced unresectable pancreatic cancer (URPC) was evaluated. M…

Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer Open

Yuan Zhou, Makoto Sakai, Yang Li, Yoshiki Kubota, Masahiko Okamoto , et al. · 2023

Carbon-ion radiotherapy (CIRT) is one of the most effective radiotherapeutic modalities. This study aimed to select robust-beam configurations (BC) by water equivalent thickness (WET) analysis in passive CIRT for pancreatic cancer. The stu…

Comprehensive analysis of Japanese nationwide cohort data of particle beam therapy for pulmonary, liver and lymph node oligometastases: particle beam therapy versus high-precision X-ray radiotherapy Open

Norihiro Aibe, Hiroyuki Ogino, Masaru Wakatsuki, Kei Fujikawa, Satoshi Teramukai , et al. · 2023

Japanese national oncological experts convened to evaluate the efficacy and safety of particle beam therapy (PT) for pulmonary, liver and lymph node oligometastases (P-OM, L-OM and LN-OM, respectively) and to conduct a statistically compar…

Impact of delivery time factor on treatment time and plan quality in tomotherapy Open

Takayuki Yagihashi, Tatsuya Inoue, Shintaro Shiba, Akihiro Yamano, Yumiko Minagawa , et al. · 2023

Background The delivery time factor (DTF) is a new parameter introduced by the RayStation treatment planning system for tomotherapy treatment planning. This study investigated the effects of this factor on various tomotherapy plans. Method…

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