Explanipedia

High-Fat Feeding Alters Circulating Triglyceride Composition: Roles of FFA Desaturation and ω-3 Fatty Acid Availability Open

Tong Shen, Youngtaek Oh, Shinwu Jeong, Suengmok Cho, Oliver Fiehn , et al. · 2024

Hypertriglyceridemia is a risk factor for type 2 diabetes and cardiovascular disease (CVD). Plasma triglycerides (TGs) are a key factor for assessing the risk of diabetes or CVD. However, previous lipidomics studies have demonstrated that …

Regulatory Effects of GPR158 Overexpression in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways Open

María Fernanda Suárez, Tatsuo Itakura, Satyabrata Pany, Shinwu Jeong, Shravan K. Chintala , et al. · 2023

Elevated intraocular pressure (IOP), the major risk factor for glaucoma, is caused by decreased outflow through the trabecular meshwork (TM). The pathophysiology of ocular hypertension has been linked to stress pathways, including fibrosis…

Recombinant Human Clusterin Seals Damage to the Ocular Surface Barrier in a Mouse Model of Ophthalmic Preservative-Induced Epitheliopathy Open

Shravan K. Chintala, Jinhong Pan, Sandeep Satapathy, Rebecca Condruti, Zixuan Hao , et al. · 2023

There is a significant unmet need for therapeutics to treat ocular surface barrier damage, also called epitheliopathy, due to dry eye and related diseases. We recently reported that the natural tear glycoprotein CLU (clusterin), a molecula…

Clusterin, other extracellular chaperones, and eye disease Open

Mark R. Wilson, Sandeep Satapathy, Shinwu Jeong, M. Elizabeth Fini · 2021

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) are localized in the nucleus of retinal Müller glial cells and modulated by cytokines and oxidative stress Open

Eun-Jin Lee, Mengmei Zheng, Cheryl M. Craft, Shinwu Jeong · 2021

Matrix metalloproteinases (MMPs) are involved in the pathology of numerous inflammatory retinal degenerations, including retinitis pigmentosa (RP). Our previous work revealed that intravitreal injections with tissue inhibitor of metallopro…

Assessment of inner retinal oxygen metrics and thickness in a mouse model of inherited retinal degeneration Open

Mansour Rahimi, Sophie Leahy, Nathanael Matei, Norman P. Blair, Shinwu Jeong , et al. · 2021

Therapeutic Potential of the Molecular Chaperone and Matrix Metalloproteinase Inhibitor Clusterin for Dry Eye Open

M. Elizabeth Fini, Shinwu Jeong, Mark R. Wilson · 2020

Evidence is presented herein supporting the potential of the natural homeostatic glycoprotein CLU (clusterin) as a novel therapeutic for the treatment of dry eye. This idea began with the demonstration that matrix metalloproteinase MMP9 is…

GPR158 Modulates Expression of Genes Associated with Extracellular Matrix (ECM) Deposition in Trabecular Meshwork Cells Open

María F. Suárez, Satyabrata Pany, Tatsuo Itakura, Shinwu Jeong, M. Elizabeth Fini · 2020

Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse Open

M. Elizabeth Fini, Shinwu Jeong, Haiyan Gong, Rafael Martínez-Carrasco, Nora Laver , et al. · 2019

Photoreceptor Survival Factor, Clusterin, is Enriched in Human Retinal Pigment Epithelial Exosomes Open

Shinwu Jeong, Andrew Vargas, Kyra L. Yamamoto, Eun-Jin Lee, Cheryl M. Craft · 2019

GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure Open

Tatsuo Itakura, Andrew R. Webster, Shravan K. Chintala, Yuchen Wang, José M. González , et al. · 2019

Purpose: GPR158 is a newly characterized family C G-protein-coupled receptor, previously identified in functional screens linked with biological stress, including one for susceptibility to ocular hypertension/glaucoma induced…

Dynasore protects the ocular surface against damaging oxidative stress Open

Andrew R. Webster, Shravan K. Chintala, Jasmine Kim, Michelle Ngan, Tatsuo Itakura , et al. · 2018

Water soluble "vital" dyes are commonly used clinically to evaluate health of the ocular surface; however, staining mechanisms remain poorly understood. Recent evidence suggests that sublethal damage stimulates vital dye uptake by individu…

Clusterin from human clinical tear samples: Positive correlation between tear concentration and Schirmer strip test results Open

Valerie Yu, Dhruva Bhattacharya, Andrew R. Webster, Aditi Bauskar, Charles W. Flowers , et al. · 2018

Targeting of Dynamin, an Essential Regulator of Endocytosis, Protects the Ocular Surface against Oxidative Stress Open

Andrew R. Webster, Shravan K. Chintala, Joseph T. Barr, Noorjahan Panjwani, Pablo Argüeso , et al. · 2018

Contents Open

L Lee, Dana K. Andersen, Reiko Ashida, William R. Brugge, M Canto , et al. · 2017

Galectin-1 ameliorates dry eye disease Open

Paula Kataguiri, Wei‐Sheng Chen, Zhiyi Cao, Victor G. Sendra, Pedram Hamrah , et al. · 2016

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine Open

M. Elizabeth Fini, Stephen G. Schwartz, Xiaoyi Gao, Shinwu Jeong, Nitin Patel , et al. · 2016

A cell‐based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair Open

Gabriel M. Gordon, Adriana J. LaGier, C. Ponchel, Aditi Bauskar, Tatsuo Itakura , et al. · 2015

The goal of this study was to develop and validate a simple but quantitative cell‐based assay to identify compounds that might be used pharmaceutically to give tissue repair a more regenerative character. The cornea was used as the model, …

GPR158 subcellular localization in PCa cell lines and PHPECs. Open

Nitin Patel, Tatsuo Itakura, Shinwu Jeong, Chun‐Peng Liao, Pradip Roy‐Burman , et al. · 2015

Subcellular protein fractionation was carried out in LNCaP, C4-2B, PC-3 and DU145 cells, as well as PHPECs. The amount of protein loaded for each fraction is indicated on the panels. Western blotting was performed using anti-ICD GPR158 ant…

Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye Open

Aditi Bauskar, Wendy J. Mack, Jérôme Mauris, Pablo Argüeso, Martin Heur , et al. · 2015

Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU leve…

Loss of CD147 results in impaired epithelial cell differentiation and malformation of the meibomian gland Open

Jérôme Mauris, Julia Dieckow, Stefan Schob, Benjamin Pulli, Mark P. Hatton , et al. · 2015

Meibomian gland dysfunction is a leading cause of ocular surface disease. However, little is known about the regulatory processes that control the development and maintenance of this sebaceous gland. Here, we identify a novel function for …

Identification of a Novel Mucin Gene<i>HCG22</i>Associated With Steroid-Induced Ocular Hypertension Open

Shinwu Jeong, Nitin Patel, Christopher K. Edlund, Jaana Hartiala, Dennis J. Hazelett , et al. · 2015

Identification of two independent QTLs that could affect expression of the HCG22 mucin gene product via two different mechanisms (transcription or secretion) is highly suggestive of a role in steroid-induced OH.

Expression and Functional Role of Orphan Receptor GPR158 in Prostate Cancer Growth and Progression Open

Nitin Patel, Tatsuo Itakura, Shinwu Jeong, Chun‐Peng Liao, Pradip Roy‐Burman , et al. · 2015

Prostate cancer (PCa) is the second-leading cause of cancer-related mortality, after lung cancer, in men from developed countries. In its early stages, primary tumor growth is dependent on androgens, thus generally can be controlled by and…

Chondrogenesis in scleral stem/progenitor cells and its association with form-deprived myopia in mice. Open

Pei‐Chang Wu, Chia‐Ling Tsai, Gabriel M. Gordon, Shinwu Jeong, Tatsuo Itakura , et al. · 2015

Based on the concept of stem cells possessing multipotent differentiation potentials, scleral chondrogenesis induced by SSPCs may play a role in myopia development. The increased expressions of the cartilage-associated proteins Col2 and α-…

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