Shinya Imada YOU? Author Swipe

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Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis Open

Omid Omrani, Christiane Brenner, Feyza Cansiz, Shinya Imada, Jonas Rösler , et al. · 2025

Ageing dampens the regenerative potential of intestinal epithelium across species including humans, yet the underlying causes remain elusive. Here we characterized the temporal dynamics of regeneration following injury induced by 5-fluorou…

Leveraging platinum-protein interactions to overcome chemoresistance Open

Fang Wang, Jonathan Braverman, George Eng, Ozen Leylek, Nicholas L. Petrone , et al. · 2025

The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism Open

Ahmed Rattani, Cora E. Anderson, William V. Trim, Esteban Garita, Shinya Imada , et al. · 2025

APC, the core scaffold of the Wnt destruction complex, targets the transcriptional co-activator β-catenin for proteolysis. There is no convincing evidence that APC directs degradation of other substrates. Using a reconstituted cytosolic ex…

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics Open

Inbal Avraham‐Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada , et al. · 2025

While advances in single cell genomics have helped to chart the cellular components of tumor ecosystems, it has been more challenging to characterize their specific spatial organization and functional interactions. Here, we combine single …

Author response: Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics Open

Inbal Avraham‐Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada , et al. · 2025

Polyamines buffer labile iron to suppress ferroptosis Open

Pushkal Sharma, Heather R. Keys, Sebastian Müller, Ivan S. Pires, R. S. Mansell , et al. · 2025

Summary Polyamines are essential and evolutionarily conserved metabolites present at millimolar concentrations in mammalian cells. Cells tightly regulate polyamine homeostasis through complex feedback mechanisms, yet the precise role neces…

Genetically encoded fluorescent reporter for polyamines Open

Pushkal Sharma, Colin Y. Kim, Heather R. Keys, Shinya Imada, Anna Joseph , et al. · 2025

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics Open

Inbal Avraham‐Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada , et al. · 2025

While advances in single cell genomics have helped to chart the cellular components of tumor ecosystems, it has been more challenging to characterize their specific spatial organization and functional interactions. Here, we combine single …

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics Open

Inbal Avraham‐Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada , et al. · 2025

While advances in single cell genomics have helped to chart the cellular components of tumor ecosystems, it has been more challenging to characterize their specific spatial organization and functional interactions. Here, we combine single …

Author response: Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics Open

Inbal Avraham‐Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada , et al. · 2025

Genetically encoded fluorescent reporter for polyamines Open

Pushkal Sharma, Colin Y. Kim, Heather R. Keys, Shinya Imada, Anna Joseph , et al. · 2024

Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson’s disease and …

Short-term post-fast refeeding enhances intestinal stemness via polyamines Open

Shinya Imada, Saleh Khawaled, Heaji Shin, Sven W. Meckelmann, Charles A. Whittaker , et al. · 2024

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis Open

Alberto E. Minetti, Omid Omrani, Christiane Brenner, Gabriele Allies, Shinya Imada , et al. · 2024

Aging hampers the regenerative potential of intestinal epithelium across species including humans, yet the underlying causes remain elusive. Here, using proteomic and metabolomic profiling of intestinal tissues together with functional ass…

SOX17 enables immune evasion of early colorectal adenomas and cancers Open

Norihiro Goto, Peter M.K. Westcott, Saori Goto, Shinya Imada, Martin S. Taylor , et al. · 2024

Correction: Inulin diet uncovers complex diet-microbiota-immune cell interactions remodeling the gut epithelium Open

Renan Oliveira Corrêa, Pollyana Ribeiro Castro, José Luís Fachi, Vinícius Dias Nirello, Salma El-Sahhar , et al. · 2023

Inulin diet uncovers complex diet-microbiota-immune cell interactions remodeling the gut epithelium Open

Renan Oliveira Corrêa, Pollyana Ribeiro Castro, José Luís Fachi, Vinícius Dias Nirello, Salma El-Sahhar , et al. · 2023

Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells Open

Shijie He, Peng Lei, Wenying Kang, Priscilla Cheung, Tao Xu , et al. · 2023

Post-fast refeeding enhances intestinal stem cell-mediated regeneration and tumourigenesis through mTORC1-dependent polyamine synthesis Open

Shinya Imada, Heaji Shin, Saleh Khawaled, Sven W. Meckelmann, Charles A. Whittaker , et al. · 2023

For more than a century, fasting regimens have improved health, lifespan, and tissue regeneration in diverse organisms, including humans. However, how fasting and post-fast refeeding impact adult stem cells and tumour formation has yet to …

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics Open

Inbal Avraham‐Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada , et al. · 2022

While advances in single cell genomics have helped to chart the cellular components of tumor ecosystems, it has been more challenging to characterize their specific spatial organization and functional interactions. Here, we combine single …

Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury Open

Norihiro Goto, Saori Goto, Shinya Imada, Sahar Hosseini, Vikram Deshpande , et al. · 2022

Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation Open

Benjamin E. Mead, Kazuki Hattori, Lauren Levy, Shinya Imada, Norihiro Goto , et al. · 2022

The cellular composition of barrier epithelia is essential to organismal homoeostasis. In particular, within the small intestine, adult stem cells establish tissue cellularity, and may provide a means to control the abundance and quality o…

Lymphatics constitute a novel component of the intestinal stem cell niche Open

Norihiro Goto, Shinya Imada, Vikram Deshpande, Ömer Yılmaz · 2022

SUMMARY Intestinal stem cells (ISCs) depend on niche factors for their proper function. However, the source of these ISC niche factors and how they support ISCs remain controversial due to their redundant expression patterns. Here, we repo…

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity Open

Miyeko Mana, Amanda M. Hussey, Constantine N. Tzouanas, Shinya Imada, Yesenia Barrera Millan , et al. · 2021

Stiffness Regulates Intestinal Stem Cell Fate Open

Shijie He, Peng Lei, Wenying Kang, Priscilla Cheung, Tao Xu , et al. · 2021

Little is known about how the fibrotic gut stiffening caused by inflammatory bowel diseases (IBD) directs the fate of intestinal stem cells (ISCs). To address this question we first developed a novel long-term culture of quasi-3D gut organ…

Stiffness Regulates Intestinal Stem Cell Fate Open

Shijie He, Peng Lei, Wenying Kang, Priscilla Cheung, Tao Xu , et al. · 2021

Summary Does fibrotic gut stiffening caused by inflammatory bowel diseases (IBD) direct the fate of intestinal stem cells (ISCs)? To address this question we first developed a novel long-term culture of quasi-3D gut organoids plated on hyd…

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet Open

Chia‐Wei Cheng, Moshe Biton, Adam L. Haber, Nuray Gündüz, George Eng , et al. · 2019

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet Open

Chia‐Wei Cheng, Nuray Gündüz, George Eng, Surya Tripathi, Gizem Calibasi‐Kocal , et al. · 2019

Role of lysophosphatidic acid in proliferation and differentiation of intestinal epithelial cells Open

Tasuku Konno, Takenori Kotani, Jajar Setiawan, Yuka Nishigaito, Naoki Sawada , et al. · 2019

Intestinal epithelial cells (IECs) are regenerated continuously from intestinal stem cells (ISCs) near the base of intestinal crypts in order to maintain homeostasis and structural integrity of intestinal epithelium. Epidermal growth facto…

Central bisectionectomy for hepatocellular carcinoma in a patient with indocyanine green excretory defect associated with reduced expression of the liver transporter Open

Shinya Imada, Tsuyoshi Kobayashi, Azusa Kitao, Osamu Matsui, Masakazu Hashimoto , et al. · 2016

In this case, we present a case of hepatectomy for HCC in a patient with ICG excretory defect, which may be attributable to a congenital disorder of OATP1B3 expression; however, an ICG excretory defect did not seem to have any effect on th…

Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis Open

Shinya Imada, Yoji Murata, Takenori Kotani, Masaki Hatano, Chunxiao Sun , et al. · 2016

Proper regulation of epithelial cell turnover is important for the structural integrity and homeostasis of various tissues, including the intestine. Here we show that ablation of Csk, a negative regulator of Src family kinases (SFKs), spec…

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