Shinya Kitamura
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View article: Lichen planus pigmentosus inversus presenting with clinical features mimicking acanthosis nigricans
Lichen planus pigmentosus inversus presenting with clinical features mimicking acanthosis nigricans Open
Lichen planus pigmentosus (LPP) is recognized as a rare variant of lichen planus, characterized by dermal hyperpigmentation. Specifically, a particular intertriginous variant of LPP is known as lichen planus pigmentosus inversus (LPPI). In…
View article: Eribulin inhibits tumor growth of two novel patient-derived xenograft models of Merkel cell carcinoma
Eribulin inhibits tumor growth of two novel patient-derived xenograft models of Merkel cell carcinoma Open
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with a poor prognosis in advanced cases. While MCC has been reported to be sensitive to chemotherapy and immunotherapy, only about 50% of tumors respond to these …
View article: A familial case of extramammary Paget disease: Analysis of whole-exome sequencing
A familial case of extramammary Paget disease: Analysis of whole-exome sequencing Open
Extramammary Paget disease (EMPD) is a rare, cutaneous malignancy that is most likely to occur in the genital area of the elderly population. Although there have been several reports on familial EMPD, its pathogenic germline mutations have…
View article: Clinical-histopathological features and cancer gene analysis of cutaneous epithelioid angiosarcoma: A report of 4 cases
Clinical-histopathological features and cancer gene analysis of cutaneous epithelioid angiosarcoma: A report of 4 cases Open
Angiosarcoma (AS) is a rare variant of malignant soft tissue sarcoma, representing less than 1% of all soft tissue sarcomas.1 Among the histopathological subtypes of AS, epithelioid angiosarcoma (EAS) is characterized by epithelioid morpho…
View article: Association between weight loss and death in patients with malignant melanoma: A retrospective study of 28 cases
Association between weight loss and death in patients with malignant melanoma: A retrospective study of 28 cases Open
Malignant melanoma (MM) is often associated with a poor prognosis due to metastasis and cancer death. The monitoring of prognostic factors is of vital importance, and among these factors, elevated lactate dehydrogenase (LDH) should be clos…
View article: Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft
Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft Open
Advanced cutaneous squamous cell carcinoma (cSCC) is treated with chemotherapy and/or radiotherapy, but these typically fail to achieve satisfactory clinical outcomes. There have been no preclinical studies to evaluate the effectiveness of…
View article: Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft
Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft Open
Advanced cutaneous squamous cell carcinoma (cSCC) is treated with chemotherapy and/or radiotherapy, but these typically fail to achieve satisfactory clinical outcomes. There have been no preclinical studies to evaluate the effectiveness of…
View article: Ashy dermatosis with a Wagyu beef‐like dermoscopic appearance: Report of two cases
Ashy dermatosis with a Wagyu beef‐like dermoscopic appearance: Report of two cases Open
There have been no reports as to the link between dermoscopic observations and disease activity in ashy dermatosis. We herein report two cases of ashy dermatosis displaying on dermoscopy the so‐called Wagyu beef‐like pattern, consisting of…
View article: Giant basal cell carcinoma of the scrotum: A case report and review of the literature
Giant basal cell carcinoma of the scrotum: A case report and review of the literature Open
Basal cell carcinoma (BCC) is the most common skin cancer. However, BCC on the scrotum is very rare, with an incidence of 0.03%. Giant BCC, in which the tumour is larger than 5 cm, has also been reported as a rare variant. Here, we report …
View article: HER2-Targeted Antibody–Drug Conjugates Display Potent Antitumor Activities in Preclinical Extramammary Paget’s Disease Models: In Vivo and Immunohistochemical Analyses
HER2-Targeted Antibody–Drug Conjugates Display Potent Antitumor Activities in Preclinical Extramammary Paget’s Disease Models: In Vivo and Immunohistochemical Analyses Open
Extramammary Paget’s disease (EMPD) is an adenocarcinoma that develops mainly in the genital region of older adults. The prognosis for advanced EMPD is almost always poor; thus, novel therapeutic strategies need to be developed. HER2-targe…
View article: Cyclin‐dependent kinase 4/6 inhibitors suppress tumor growth in extramammary Paget’s disease
Cyclin‐dependent kinase 4/6 inhibitors suppress tumor growth in extramammary Paget’s disease Open
Extramammary Paget’s disease (EMPD) is a rare adnexal neoplasm commonly seen in the genital areas among the senior population. The prognosis of advanced EMPD is not favorable; thus, the development of potential treatments has long been sou…
View article: Loss of FAM83H promotes cell migration and invasion in cutaneous squamous cell carcinoma via impaired keratin distribution
Loss of FAM83H promotes cell migration and invasion in cutaneous squamous cell carcinoma via impaired keratin distribution Open
Our findings reveal a critical function for FAM83H in regulating keratin distribution, as well as in the migration/invasion of cutaneous SCC, suggesting that FAM83H could be a crucial molecule in the tumorigenesis of cutaneous SCC.
View article: Hidradenitis suppurativa successfully treated with two‐stage surgery under disease control with adalimumab
Hidradenitis suppurativa successfully treated with two‐stage surgery under disease control with adalimumab Open
Hidradenitis suppurativa (HS) is a chronic inflammatory disease whose main pathogenesis is chronic follicular occlusion [1]86.7% of HS patients treated with adalimumab, a monoclonal antibody specific for tumor necrosis factor-α, achieve a …
View article: Type 1 diabetes mellitus in a melanoma patient treated with adjuvant nivolumab therapy
Type 1 diabetes mellitus in a melanoma patient treated with adjuvant nivolumab therapy Open
Although there have been also known that a few cases may develop T1DM during adjuvant use of programmed death-1 inhibitors, its clinical course has not ever been described in detail. This report presents the case of type 1 diabetes mellitu…
View article: Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma
Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma Open
Cutaneous squamous cell carcinoma (SCC) is one of the common cancers in Caucasians, accounting for 20-30% of cutaneous malignancies. The risk of metastasis is low in most patients; however, aggressive SCC is associated with very high morta…
View article: Basal Cell Carcinoma or Trichoblastoma Dermoscopic Examination of Black Macules Developing in the Same Nevus Sebaceus
Basal Cell Carcinoma or Trichoblastoma Dermoscopic Examination of Black Macules Developing in the Same Nevus Sebaceus Open
Nevus sebaceus (NS) is a common congenital birthmark, and various tumors have been reported to develop in NS. Basal cell carcinoma (BCC) seldom occurs in NS, and it is very important to be able to clinicopathologically distinguish BCC from…
View article: Pazopanib-Induced Severe Acute Pancreatitis
Pazopanib-Induced Severe Acute Pancreatitis Open
Pazopanib is an oral angiogenesis inhibitor targeting vascular endothelial growth factor receptors, platelet-derived growth factor receptors, and c-Kit approved for the treatment of renal cell carcinoma and soft tissue sarcoma. Nonselectiv…
View article: Diagnostic pitfall of localized lentigo accompanied by post-inflammatory pigmentation on the palm with a several-month history
Diagnostic pitfall of localized lentigo accompanied by post-inflammatory pigmentation on the palm with a several-month history Open
When dermatologists see acquired and wellcircumscribed pigmented macules on the palm, dorsal hand or forearm of the elderly, they tend to consider blue nevus, hematoma, nevus cell nevus and malignant melanoma as differential diagnoses [1].
View article: A case of myxoid liposarcoma
A case of myxoid liposarcoma Open
症例は29歳，男性。8ヵ月前から生じた右大腿内側の粘液型脂肪肉腫に対して，手術目的に当科に入院した。術前に施行したCTでは薄筋に接して内部の均一な，楕円形の腫瘤を認めた。MRIではT1強調画像で均一な低信号，T2強調像で均一な高信号を認めた。エコーでは境界明瞭で全域に血流の豊富な腫瘤を認め，内部は大小の隔壁で区切られていた。エラストグラフィでは辺縁部で硬く，内部で柔らかい像を認めた。腫瘍細胞は多数の隔壁で区切られており，周囲との境界は明瞭であった。病理所見では大量の粘液基質…