Shinya Toyokuni
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View article: Dual lipid modulation overcomes ferroptosis resistance in high-risk neuroblastoma
Dual lipid modulation overcomes ferroptosis resistance in high-risk neuroblastoma Open
Ferroptosis—an iron-dependent form of cell death triggered by phospholipid peroxidation—has emerged as a promising therapeutic avenue in cancer treatment. Although neuroblastoma (NB) has been identified as a ferroptosis susceptible cancer,…
View article: L-ascorbate prevents non-alcoholic steatohepatitis-based hepatocarcinogenesis in Sod1/Prdx4 double-knockout mice
L-ascorbate prevents non-alcoholic steatohepatitis-based hepatocarcinogenesis in Sod1/Prdx4 double-knockout mice Open
Superoxide dismutase 1 (Sod1) and peroxiredoxin 4 (Prdx4) double knockout (DKO) causes symptoms similar to non-alcoholic steatohepatitis (NASH) even at younger ages. This study revealed that DKO mice exhibited high mortality, and surviving…
View article: Iron-catalyzed oxidative stress compromises cancer promotional effect of BRCA2 haploinsufficiency through mitochondria-targeted ferroptosis
Iron-catalyzed oxidative stress compromises cancer promotional effect of BRCA2 haploinsufficiency through mitochondria-targeted ferroptosis Open
View article: Terrestrial iron sulfide minerals induce distinct regulation of intracellular redox homeostasis and iron assimilation
Terrestrial iron sulfide minerals induce distinct regulation of intracellular redox homeostasis and iron assimilation Open
Repeated exposure to airborne terrestrial natural minerals may cause pneumoconiosis and lung cancer, among which iron sulfide is identified as an aggravating factor. In the biological system, iron-sulfur cluster is an inorganic cofactor th…
View article: Lunar life drives jawbone formation
Lunar life drives jawbone formation Open
View article: L-Ascorbate Prevents Non-Alcoholic Steatohepatitis-Based Hepatocarcinogenesis in <em>Sod1</em>/<em>Prdx4</em> Double-Knockout Mice
L-Ascorbate Prevents Non-Alcoholic Steatohepatitis-Based Hepatocarcinogenesis in <em>Sod1</em>/<em>Prdx4</em> Double-Knockout Mice Open
Oxidative stress as well as endoplasmic reticulum (ER) stress are the major underlying factors that promote non-alcoholic steatohepatitis (NASH), which eventually leads to hepatocarcinogenesis. Knockout (KO) of superoxide dismutase 1 (Sod1…
View article: Susceptibility of <i>Brca1</i><sup>(<i>L63X/+</i>)</sup> rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer
Susceptibility of <i>Brca1</i><sup>(<i>L63X/+</i>)</sup> rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer Open
BRCA1 is one of the causative genes for hereditary breast and ovarian cancer syndrome with a high risk of early‐onset breast cancer. Whereas olaparib (OLA), an inhibitor of poly‐ADP‐ribose polymerase, has been applied as adjuvant therapy t…
View article: Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages
Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages Open
The maintenance of cellular redox balance is crucial for cell survival and homeostasis and is disrupted with aging. Selenoproteins, comprising essential antioxidant enzymes, raise intriguing questions about their involvement in hematopoiet…
View article: Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats
Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats Open
View article: Decoding the molecular enigma behind asbestos and fibrous nanomaterial-induced carcinogenesis
Decoding the molecular enigma behind asbestos and fibrous nanomaterial-induced carcinogenesis Open
Objectives: The natural fibrous mineral, asbestos, has been useful in industry for many centuries. In the 1960s, epidemiology recognized the association between asbestos exposure and mesothelioma, and in 1987 the International Agency for R…
View article: Lifelong Thioredoxin Insufficiency Promotes Chronic Kidney Disease Through Mitochondrial Dysfunction, Regulated Cell Death, and Inflammation in Txn1 Mutant Rats
Lifelong Thioredoxin Insufficiency Promotes Chronic Kidney Disease Through Mitochondrial Dysfunction, Regulated Cell Death, and Inflammation in Txn1 Mutant Rats Open
View article: Extracellular Fine Fiber-Induced Carcinogenesis and Its Prevention
Extracellular Fine Fiber-Induced Carcinogenesis and Its Prevention Open
Cancer, dysregulated proliferation of basically monoclonal autologous cells causing destruction of the preexistent normal structure, has been present from the ancient days.
View article: Iron-Catalyzed Oxidative Stress Cancels Cancer Promotional Effect of Brca2 Haploinsufficiency Through Mitochondria-Targeted Ferroptosis
Iron-Catalyzed Oxidative Stress Cancels Cancer Promotional Effect of Brca2 Haploinsufficiency Through Mitochondria-Targeted Ferroptosis Open
View article: Selective Killing of Human Breast Cancer Cells by Plasma‐Treated L‐Arginine Solution
Selective Killing of Human Breast Cancer Cells by Plasma‐Treated L‐Arginine Solution Open
l ‐arginine is a nonessential amino acid that plays an important role in normal immune function and can be used as an adjuvant treatment for cancers. The antitumor effect of nonequilibrium atmospheric pressure plasma treated l ‐arginine so…
View article: Homozygous slc25a20 zebrafish mutant reveals insights into carnitine-acylcarnitine translocase deficiency pathogenesis
Homozygous slc25a20 zebrafish mutant reveals insights into carnitine-acylcarnitine translocase deficiency pathogenesis Open
View article: Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract
Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract Open
The human lens is composed of a monolayer of lens epithelial cells (LECs) and elongated fibers that align tightly but are separated by the plasma membrane. The integrity of the lens plasma membrane is crucial for maintaining lens cellular …
View article: Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease
Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease Open
View article: Ferroptosis in health and disease
Ferroptosis in health and disease Open
View article: Fatal COVID-19 pulmonary disease involves ferroptosis
Fatal COVID-19 pulmonary disease involves ferroptosis Open
SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-depend…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: A viral FLIP protein, E8, exogenously-expressed in the mesenchymal lineage of mice leads to bone malformations, lipoatrophy, and muscular atrophy
A viral FLIP protein, E8, exogenously-expressed in the mesenchymal lineage of mice leads to bone malformations, lipoatrophy, and muscular atrophy Open
The equine herpesvirus 2 E8 protein is a member of the viral FLIP family, and as such, it is a potent inhibitor of death receptor-induced apoptosis in cultured cells. To extend our study of the effects of E8 to animals, we generated a mous…
View article: Association of poly(<i>rC</i>)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria
Association of poly(<i>rC</i>)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria Open
Iron is essential for all the lives and mitochondria integrate iron into heme and Fe-S clusters for diverse use as cofactors. Here, we screened mitochondrial proteins in KU812 human chronic myelogenous leukemia cells by glutathione S-
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis Open
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell …
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: A guideline on the molecular ecosystem regulating ferroptosis
A guideline on the molecular ecosystem regulating ferroptosis Open
View article: Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models
Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models Open
Extracellular vesicles (EVs) are complex structures that transport various DNA, RNA, and protein. Recently, new EV secretion mechanisms have been identified through the iron regulatory system in mammalian cells. We revealed that ferroptosi…
View article: Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation
Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation Open
Epstein-Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus that is causally associated with several malignancies. In addition to latent factors, lytic replication contributes to cancer development. In this study, we examined w…
View article: <i> Brca2 <sup>(p.T1942fs/+)</sup> </i> dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells
<i> Brca2 <sup>(p.T1942fs/+)</sup> </i> dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells Open
Pathogenic variants of BRCA1/2 constitute hereditary breast and ovarian cancer (HBOC) syndrome, and BRCA1/2 mutant is a risk for various cancers. Whereas the clinical guideline for HBOC patients has been organized for the the…
View article: Heat-treated and/or lysozyme-treated <i>Enterococcus faecalis</i> (FK-23) improves the progression of renal disease in a unilateral ischemia-reperfusion injury rat model
Heat-treated and/or lysozyme-treated <i>Enterococcus faecalis</i> (FK-23) improves the progression of renal disease in a unilateral ischemia-reperfusion injury rat model Open
The prevalence of chronic kidney disease (CKD) is increasing owing to the elderly population. Here, we investigated the effects of heat-treated Enterococcus faecalis (FK-23) and lysozyme-treated FK-23 (LFK) on the progression of CKD…