Shinya Wada
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View article: Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle‐Based Vaccines for Cancer Immunotherapy
Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle‐Based Vaccines for Cancer Immunotherapy Open
Background We have previously developed a gold nanoparticle (GNP)‐based anti‐cancer immunotherapy, termed integrated glyco‐nanovaccine (iGN). The iGN is composed of GNPs conjugated to a synthetic toll‐like receptor (TLR) 7 ligand, an antig…
View article: Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy
Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy Open
These findings underscore the potential of iGN as a strategy to enhance cancer immunotherapy, particularly when used in combination with immune checkpoint blockade, to bolster anti-tumor immune responses and improve therapeutic outcomes.
View article: Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy
Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy Open
Cancer immunotherapy, particularly using immune checkpoint inhibitors, has revolutionized cancer treatment; however, its efficacy remains limited to a subset of patients. Nanoparticles have potential in cancer treatment because they offer …
View article: Enhanced Reduction of Ferredoxin in PGR5-Deficient Mutant of Arabidopsis thaliana Stimulated Ferredoxin-Dependent Cyclic Electron Flow around Photosystem I
Enhanced Reduction of Ferredoxin in PGR5-Deficient Mutant of Arabidopsis thaliana Stimulated Ferredoxin-Dependent Cyclic Electron Flow around Photosystem I Open
The molecular entity responsible for catalyzing ferredoxin (Fd)-dependent cyclic electron flow around photosystem I (Fd-CEF) remains unidentified. To reveal the in vivo molecular mechanism of Fd-CEF, evaluating ferredoxin reduction–oxidati…
View article: Enhanced Reduction of Ferredoxin in PGR5-deficient mutant of<em> Arabidopsis thaliana</em> Stimulated Ferredoxin-dependent Cyclic Electron Flow around Photosystem I
Enhanced Reduction of Ferredoxin in PGR5-deficient mutant of<em> Arabidopsis thaliana</em> Stimulated Ferredoxin-dependent Cyclic Electron Flow around Photosystem I Open
The molecular entity that catalyzes ferredoxin (Fd)-dependent cyclic electron flow around photosystem I (PSI) (Fd-CEF) remains unknown. To elucidate the in vivo molecular mechanism of Fd-CEF, the evaluation of Fd reduction‒oxidation kineti…
View article: Evaluating the Oxidation Rate of Reduced Ferredoxin in Arabidopsis thaliana Independent of Photosynthetic Linear Electron Flow: Plausible Activity of Ferredoxin-Dependent Cyclic Electron Flow around Photosystem I
Evaluating the Oxidation Rate of Reduced Ferredoxin in Arabidopsis thaliana Independent of Photosynthetic Linear Electron Flow: Plausible Activity of Ferredoxin-Dependent Cyclic Electron Flow around Photosystem I Open
The activity of ferredoxin (Fd)-dependent cyclic electron flow (Fd-CEF) around photosystem I (PSI) was determined in intact leaves of Arabidopsis thaliana. The oxidation rate of Fd reduced by PSI (vFd) and photosynthetic linear electron fl…
View article: Higher Reduced State of Fe/S-Signals, with the Suppressed Oxidation of P700, Causes PSI Inactivation in Arabidopsis thaliana
Higher Reduced State of Fe/S-Signals, with the Suppressed Oxidation of P700, Causes PSI Inactivation in Arabidopsis thaliana Open
Environmental stress increases the risk of electron accumulation in photosystem I (PSI) of chloroplasts, which can cause oxygen (O2) reduction to superoxide radicals and decreased photosynthetic ability. We used three Arabidopsis thaliana …
View article: Suppression of chloroplast triose phosphate isomerase evokes inorganic phosphate-limited photosynthesis in rice
Suppression of chloroplast triose phosphate isomerase evokes inorganic phosphate-limited photosynthesis in rice Open
The availability of inorganic phosphate (Pi) for ATP synthesis is thought to limit photosynthesis at elevated [CO2] when Pi regeneration via sucrose or starch synthesis is limited. We report here another mechanism for the occurrence of Pi-…
View article: Identification of a Novel Mutation Exacerbated the PSI Photoinhibition in pgr5/pgrl1 Mutants; Caution for Overestimation of the Phenotypes in Arabidopsis pgr5-1 Mutant
Identification of a Novel Mutation Exacerbated the PSI Photoinhibition in pgr5/pgrl1 Mutants; Caution for Overestimation of the Phenotypes in Arabidopsis pgr5-1 Mutant Open
PSI photoinhibition is usually avoided through P700 oxidation. Without this protective mechanism, excess light represents a potentially lethal threat to plants. PGR5 is suggested to be a major component of cyclic electron transport around …
View article: Physiological Roles of Flavodiiron Proteins and Photorespiration in the Liverwort Marchantia polymorpha
Physiological Roles of Flavodiiron Proteins and Photorespiration in the Liverwort Marchantia polymorpha Open
Against the potential risk in oxygenic photosynthesis, that is, the generation of reactive oxygen species, photosynthetic electron transport needs to be regulated in response to environmental fluctuations. One of the most important regulat…
View article: Photosynthetic Parameters Show Specific Responses to Essential Mineral Deficiencies
Photosynthetic Parameters Show Specific Responses to Essential Mineral Deficiencies Open
In response to decreases in the assimilation efficiency of CO2, plants oxidize the reaction center chlorophyll (P700) of photosystem I (PSI) to suppress reactive oxygen species (ROS) production. In hydro-cultured sunflower leaves experienc…
View article: Intrinsic Fluctuations in Transpiration Induce Photorespiration to Oxidize P700 in Photosystem I
Intrinsic Fluctuations in Transpiration Induce Photorespiration to Oxidize P700 in Photosystem I Open
Upon exposure to environmental stress, the primary electron donor in photosystem I (PSI), P700, is oxidized to suppress the production of reactive oxygen species that could oxidatively inactivate the function of PSI. The illumination of ri…
View article: Photorespiration Coupled With CO2 Assimilation Protects Photosystem I From Photoinhibition Under Moderate Poly(Ethylene Glycol)-Induced Osmotic Stress in Rice
Photorespiration Coupled With CO2 Assimilation Protects Photosystem I From Photoinhibition Under Moderate Poly(Ethylene Glycol)-Induced Osmotic Stress in Rice Open
Photorespiration coupled with CO2 assimilation is thought to act as a defense system against photoinhibition caused by osmotic stress. In the present study, we examined whether such a mechanism is operative for the protection of photosyste…
View article: Photorespiration Enhances Acidification of the Thylakoid Lumen, Reduces the Plastoquinone Pool, and Contributes to the Oxidation of P700 at a Lower Partial Pressure of CO2 in Wheat Leaves
Photorespiration Enhances Acidification of the Thylakoid Lumen, Reduces the Plastoquinone Pool, and Contributes to the Oxidation of P700 at a Lower Partial Pressure of CO2 in Wheat Leaves Open
The oxidation of P700 in photosystem I (PSI) is a robust mechanism that suppresses the production of reactive oxygen species. We researched the contribution of photorespiration to the oxidation of P700 in wheat leaves. We analyzed the effe…
View article: CHK1 Inhibitor-Based Checkpoint Abrogation: A Classic, Yet New Therapeutic Approach in Advanced Cancer
CHK1 Inhibitor-Based Checkpoint Abrogation: A Classic, Yet New Therapeutic Approach in Advanced Cancer Open
Recent advances in small molecule kinase inhibitors have markedly improved patient survival in various types of cancer. Most of these successes can be attributed to the concept of “targeting driver oncogenes,” as in the case of tyrosine ki…
View article: Oxidation of P700 Induces Alternative Electron Flow in Photosystem I in Wheat Leaves
Oxidation of P700 Induces Alternative Electron Flow in Photosystem I in Wheat Leaves Open
Oxygen (O2)-evolving photosynthetic organisms oxidize the reaction center chlorophyll, P700, in photosystem I (PSI) to suppress the production of reactive oxygen species. The oxidation of P700 is accompanied by alternative electron flow in…
View article: Responses of the Photosynthetic Electron Transport Reactions Stimulate the Oxidation of the Reaction Center Chlorophyll of Photosystem I, P700, under Drought and High Temperatures in Rice
Responses of the Photosynthetic Electron Transport Reactions Stimulate the Oxidation of the Reaction Center Chlorophyll of Photosystem I, P700, under Drought and High Temperatures in Rice Open
It is of interest how photosynthetic electron transport (PET) reactions respond to excess light energy caused by the combination of drought stress and high temperatures. Since such information is scarcely available for photosystem I (PSI),…
View article: Vacuolar Protein Degradation via Autophagy Provides Substrates to Amino Acid Catabolic Pathways as an Adaptive Response to Sugar Starvation in Arabidopsis thaliana
Vacuolar Protein Degradation via Autophagy Provides Substrates to Amino Acid Catabolic Pathways as an Adaptive Response to Sugar Starvation in Arabidopsis thaliana Open
The vacuolar lytic degradation of proteins releases free amino acids that plants can use instead of sugars for respiratory energy production. Autophagy is a major cellular process leading to the transport of proteins into the vacuole for d…
View article: Flavodiiron Protein Substitutes for Cyclic Electron Flow without Competing CO<sub>2</sub> Assimilation in Rice
Flavodiiron Protein Substitutes for Cyclic Electron Flow without Competing CO<sub>2</sub> Assimilation in Rice Open
Flavodiiron protein (FLV) mediates photoreduction of O2 to H2O. It is conserved from cyanobacteria to gymnosperms but not in angiosperms. The introduction of a moss (Physcomitrella patens) FLV (PpFLV) gene into Arabidopsis (Arabidopsis tha…
View article: Autophagy Supports Biomass Production and Nitrogen Use Efficiency at the Vegetative Stage in Rice
Autophagy Supports Biomass Production and Nitrogen Use Efficiency at the Vegetative Stage in Rice Open
Much of the nitrogen in leaves is distributed to chloroplasts, mainly in photosynthetic proteins. During leaf senescence, chloroplastic proteins, including Rubisco, are rapidly degraded, and the released nitrogen is remobilized and reused …
View article: Establishment of Monitoring Methods for Autophagy in Rice Reveals Autophagic Recycling of Chloroplasts and Root Plastids during Energy Limitation
Establishment of Monitoring Methods for Autophagy in Rice Reveals Autophagic Recycling of Chloroplasts and Root Plastids during Energy Limitation Open
Autophagy is an intracellular process leading to vacuolar or lysosomal degradation of cytoplasmic components in eukaryotes. Establishment of proper methods to monitor autophagy was a key step in uncovering its role in organisms, such as ye…