Sirong He
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View article: <i>Legionella pneumophila</i> Effector Protein LegU1 Mediates the Ubiquitination of Endoplasmic Reticulum Chaperone BiP
<i>Legionella pneumophila</i> Effector Protein LegU1 Mediates the Ubiquitination of Endoplasmic Reticulum Chaperone BiP Open
The facultative intracellular pathogen Legionella pneumophila, which causes Legionnaires' disease, translocates over 300 effector proteins into the host cell. By hijacking numerous host cellular signaling pathways, these effectors p…
View article: Bispecific antibody research and development among China, the United States and Europe
Bispecific antibody research and development among China, the United States and Europe Open
View article: Gene Editing in Ganoderma lucidum: Development, Challenges, and Future Prospects
Gene Editing in Ganoderma lucidum: Development, Challenges, and Future Prospects Open
As an emerging and innovative technology, gene-editing technology has been widely applied in crop breeding, human disease treatment, animal model research, drug and vaccine development, and microbial engineering. We mainly introduce the de…
View article: Associations of serum lipids with comorbidity of hypertension and diabetes among Chinese older adults: a population-based cohort study
Associations of serum lipids with comorbidity of hypertension and diabetes among Chinese older adults: a population-based cohort study Open
View article: Structure, ingredient, and function-based biomimetic scaffolds for accelerated healing of tendon-bone interface
Structure, ingredient, and function-based biomimetic scaffolds for accelerated healing of tendon-bone interface Open
View article: Investigating the Pharmacological Mechanisms of Total Flavonoids from Eucommia ulmoides Oliver Leaves for Ischemic Stroke Protection
Investigating the Pharmacological Mechanisms of Total Flavonoids from Eucommia ulmoides Oliver Leaves for Ischemic Stroke Protection Open
The aim of this study was to explore how the total flavonoids from Eucommia ulmoides leaves (EULs) regulate ischemia-induced nerve damage, as well as the protective effects mediated by oxidative stress. The cell survival rate was significa…
View article: Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT signaling of CD4+ cells
Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT signaling of CD4+ cells Open
As an inflammatory disease with a disrupted immune system, cytokine disorders in atopic dermatitis (AD) are closely related to the abnormal activation of JAK-STAT signal pathway. The critical relevance of the JAK-STAT signaling pathway to …
View article: Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery
Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery Open
Based on the current available evidence, fibrin sealant use may result in little to no difference in the rate of POPF in people undergoing distal pancreatectomy. The evidence is very uncertain about the effect of fibrin sealant use on the …
View article: Design, Synthesis and Biological Evaluation of Multi-Target Anti-Cancer Agent PYR26
Design, Synthesis and Biological Evaluation of Multi-Target Anti-Cancer Agent PYR26 Open
This study investigates the synthesis of a new compound, PYR26, and the multi-target mechanism of PYR26 inhibiting the proliferation of HepG2 human hepatocellular carcinoma cells. PYR26 significantly inhibits the growth of HepG2 cells (p <…
View article: CTLA4Ig/VISTAIg combination therapy selectively induces CD4<sup>+</sup> T cell‐mediated immune tolerance by targeting the SOCS1 signaling pathway in porcine islet xenotransplantation
CTLA4Ig/VISTAIg combination therapy selectively induces CD4<sup>+</sup> T cell‐mediated immune tolerance by targeting the SOCS1 signaling pathway in porcine islet xenotransplantation Open
T cell inhibitory receptors can regulate the proliferation or function of T cells by binding to their ligands and present a unique opportunity to manage destructive immune responses during porcine islet xenotransplantation. We applied ex v…
View article: Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2α by miR-96-5p
Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2α by miR-96-5p Open
View article: <p>Multifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets</p>
Multifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets Open
Islet transplantation is regarded as the most promising treatment for type 1 diabetes (T1D). However, the function of grafted islet could be damaged on account of transplant rejection and/or hypoxia several years later after transplantatio…
View article: MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma
MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma Open
View article: LINC00963 targeting miR‐128‐3p promotes acute kidney injury process by activating JAK2/STAT1 pathway
LINC00963 targeting miR‐128‐3p promotes acute kidney injury process by activating JAK2/STAT1 pathway Open
The role of long non‐coding RNAs (lncRNAs) in kidney diseases has been gradually discovered in recent years. LINC00963, as an lncRNA, was found to be involved in chronic renal failure. However, the role and molecular mechanisms of LINC0096…
View article: Age-specific differential changes on gut microbiota composition in patients with major depressive disorder
Age-specific differential changes on gut microbiota composition in patients with major depressive disorder Open
Emerging evidence has shown the age-related changes in gut microbiota, but few studies were conducted to explore the effects of age on the gut microbiota in patients with major depressive disorder (MDD). This study was performed to identif…
View article: Duct-to-mucosa pancreaticojejunostomy for the prevention of postoperative pancreatic fistula following pancreaticoduodenectomy
Duct-to-mucosa pancreaticojejunostomy for the prevention of postoperative pancreatic fistula following pancreaticoduodenectomy Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the benefits and harms of duct‐to‐mucosa pancreaticojejunostomy for the reconstruction of pancreatic digestive continuity in participants und…
View article: Continuous veno-venous hemofiltration for severe acute pancreatitis
Continuous veno-venous hemofiltration for severe acute pancreatitis Open
The quality of the current evidence is very low or low. For both comparisons addressed in this review, data are sparse. It is unclear whether CVVH has any effect on mortality or complications in patients with severe acute pancreatitis. It …
View article: Heparinized silk fibroin hydrogels loading FGF1 promote the wound healing in rats with full-thickness skin excision
Heparinized silk fibroin hydrogels loading FGF1 promote the wound healing in rats with full-thickness skin excision Open
View article: <p>Prognostic Values Of Preoperative Serum CEA And CA125 Levels And Nomograms For Young Breast Cancer Patients</p>
Prognostic Values Of Preoperative Serum CEA And CA125 Levels And Nomograms For Young Breast Cancer Patients Open
Preoperative serum CEA and CA125 levels could be the independent prognostic factors for OS, and the nomograms including these two variables provide more personal forecasts information to help physicians optimize treatment for young breast …
View article: Prophylactic abdominal drainage for pancreatic surgery
Prophylactic abdominal drainage for pancreatic surgery Open
The use of surgical drains has been considered mandatory after pancreatic surgery. The role of prophylactic abdominal drainage to reduce postoperative complications after pancreatic surgery is controversial.
View article: MicroRNA-410-3p attenuates gemcitabine resistance in pancreatic ductal adenocarcinoma by inhibiting HMGB1-mediated autophagy
MicroRNA-410-3p attenuates gemcitabine resistance in pancreatic ductal adenocarcinoma by inhibiting HMGB1-mediated autophagy Open
Gemcitabine-based chemotherapy is the most common treatment option for pancreatic ductal adenocarcinoma (PDAC). However, it offers little therapeutic value in many cases due to the rapid development of chemoresistance. MicroRNAs (miRNAs) h…
View article: A preclinical evaluation of alternative site for islet allotransplantation
A preclinical evaluation of alternative site for islet allotransplantation Open
The bone marrow cavity (BMC) has recently been identified as an alternative site to the liver for islet transplantation. This study aimed to compare the BMC with the liver as an islet allotransplantation site in diabetic monkeys. Diabetes …
View article: HMGB1 translocation and release mediate cigarette smoke–induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway
HMGB1 translocation and release mediate cigarette smoke–induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway Open
We performed studies to determine the role of high-mobility group box 1 (HMGB1) in cigarette smoke (CS)–induced pulmonary inflammation. After mice were exposed to five cigarettes four times a day for 3 d, toll-like receptor 4 (TLR4) expres…
View article: Prophylactic abdominal drainage for pancreatic surgery
Prophylactic abdominal drainage for pancreatic surgery Open
It was unclear whether routine abdominal drainage had any effect on the reduction of mortality at 30 days, or postoperative complications after pancreatic surgery. Moderate-quality evidence suggested that routine abdominal drainage probabl…