Shixian Hu
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View article: Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits
Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits Open
Our study largely expands the compositional and functional landscape of the human gut microbiome, providing a crucial resource for studying the role of gut microbiome for regional health disparities.
View article: The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution
The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution Open
Here, we introduce the Chinese Gut Viral Reference (CGVR) set, consisting of 120,568 viral genomes from 3234 deeply sequenced fecal samples collected nationwide, covering 72,751 viral operational taxonomic units (vOTUs), nearly 90% of whic…
View article: Gut microbiota mediates trafficking of intestinal T cells to the brain to exacerbate neuroinflammation after ischemic stroke
Gut microbiota mediates trafficking of intestinal T cells to the brain to exacerbate neuroinflammation after ischemic stroke Open
Ischemic stroke disrupts neuroimmune homeostasis, leading to pronounced neurological impairment, yet the cellular mechanisms remain incompletely defined. Here, we construct a high-resolution spatiotemporal immune atlas of infarcted brain r…
View article: Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease
Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease Open
Intestinal stricture remains one of the most challenging complications in Crohn's disease, and its underlying mechanisms are poorly understood. Accumulating evidence suggests that gut microbiota is significantly altered in stenotic intesti…
View article: Integrating multi-omics data to reveal the host-microbiota interactome in inflammatory bowel disease
Integrating multi-omics data to reveal the host-microbiota interactome in inflammatory bowel disease Open
Numerous studies have accelerated the knowledge expansion on the role of gut microbiota in inflammatory bowel disease (IBD). However, the precise mechanisms behind host-microbe cross-talk remain largely undefined, due to the complexity of …
View article: Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing
Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing Open
Aim Masticatory dysfunction due to tooth loss is a potentially modifiable risk for mortality, but the pathway behind that remains to be investigated. This prospective study aimed to examine the role of diet and ageing in the associations b…
View article: Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study
Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study Open
Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research has primarily focused on differential abundances, our study highlights the role of non‐di…
View article: P0765 Insights into personalized biologic therapy with infliximab and ustekinumab: The predictive role of IL12P40 levels for mucosal healing outcomes
P0765 Insights into personalized biologic therapy with infliximab and ustekinumab: The predictive role of IL12P40 levels for mucosal healing outcomes Open
Background Current consensus guidelines recommend the early initiation of biologic therapies for managing Crohn’s disease (CD). Among the first-line options, infliximab (IFX) and ustekinumab (UST) have shown significant efficacy. However, …
View article: Dissecting the causal association of periodontitis with biological aging and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis
Dissecting the causal association of periodontitis with biological aging and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis Open
This study presents compelling genetic evidence supporting a causal relationship between periodontitis and accelerated aging. Further research is required to validate these findings and investigate the underlying mechanisms.
View article: An atlas of the shared genetic architecture between atopic and gastrointestinal diseases
An atlas of the shared genetic architecture between atopic and gastrointestinal diseases Open
Comorbidity among atopic diseases (ADs) and gastrointestinal diseases (GIDs) has been repeatedly demonstrated by epidemiological studies, whereas the shared genetic liability remains largely unknown. Here we establish an atlas of the share…
View article: Gene expression profiling in PBMCs for acute rejection in lung transplant recipients reveals myeloid responses
Gene expression profiling in PBMCs for acute rejection in lung transplant recipients reveals myeloid responses Open
The acute rejection (AR) diagnosis depends on transbronchial biopsy, which is semi-invasive and not easily performed . Our study used the Nanostring gene expression technology on PBMCs obtained from lung transplant recipients (LTRs) to sea…
View article: Genome-wide meta-analysis associates donor-recipient non-HLA genetic mismatch with acute cellular rejection post-liver transplantation
Genome-wide meta-analysis associates donor-recipient non-HLA genetic mismatch with acute cellular rejection post-liver transplantation Open
Background: Acute cellular rejection (ACR) remains a common complication causing significant morbidity post-liver transplantation. Non–human leukocyte antigen (non-HLA) mismatches were associated with an increased risk of ACR in kidney tra…
View article: Intestinal somatic mutations in inflammatory bowel disease patients are enriched in very early onset IBD and primary immunodeficiency genes
Intestinal somatic mutations in inflammatory bowel disease patients are enriched in very early onset IBD and primary immunodeficiency genes Open
The genetic predisposition of Inflammatory bowel disease (IBD) in the germline is well-established, while the potential role of somatic mutations in IBD remains underexplored. We aim to identify somatic mutations in intestinal mucosa and s…
View article: Multi‐Omics Biomarkers for Predicting Efficacy of Biologic and Small‐Molecule Therapies in Adults With Inflammatory Bowel Disease: A Systematic Review
Multi‐Omics Biomarkers for Predicting Efficacy of Biologic and Small‐Molecule Therapies in Adults With Inflammatory Bowel Disease: A Systematic Review Open
The heterogeneity and suboptimal efficacy of biological treatments and small molecule drugs necessitate their precise selection based on biomarkers that predict therapeutic responses in inflammatory bowel disease. Recent studies have ident…
View article: Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits
Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits Open
Background A comprehensive and representative reference database is crucial for accurate taxonomic and functional profiling of the human gut microbiome in population-level studies. However, with 70% of current microbial reference data deri…
View article: Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn’s disease
Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn’s disease Open
Intestinal fibrosis is the primary cause of disability in patients with Crohn’s disease (CD), yet effective therapeutic strategies are currently lacking. Here, we report a multiomics analysis of gut microbiota and fecal/blood metabolites o…
View article: Developing a Machine-Learning Prediction Model for Infliximab Response in Crohn’s Disease: Integrating Clinical Characteristics and Longitudinal Laboratory Trends
Developing a Machine-Learning Prediction Model for Infliximab Response in Crohn’s Disease: Integrating Clinical Characteristics and Longitudinal Laboratory Trends Open
Background Achieving long-term clinical remission in Crohn’s disease (CD) with antitumor necrosis factor α (anti-TNF-α) agents remains challenging. Aims This study aims to establish a prediction model based on patients’ clinical characteri…
View article: Phospholipid metabolism-related genotypes of PLA2R1 and CERS4 contribute to nonobese MASLD
Phospholipid metabolism-related genotypes of PLA2R1 and CERS4 contribute to nonobese MASLD Open
Background: Abnormal phospholipid metabolism is linked to metabolic dysfunction–associated steatotic liver disease (MASLD) development and progression. We aimed to clarify whether genetic variants of phospholipid metabolism modify these re…
View article: Fundamental transport mechanism of mucin-2 ER-to-Golgi trafficking identifies source of ER stress in inflammatory bowel disease
Fundamental transport mechanism of mucin-2 ER-to-Golgi trafficking identifies source of ER stress in inflammatory bowel disease Open
The intestinal mucous layer relies on mucin-2 secretion. While the mucin-2 secretory pathway has been studied, endoplasmic reticulum (ER) to Golgi apparatus (Golgi) trafficking remains poorly understood. The size of mucin-2 exceeds the cap…
View article: Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content
Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content Open
Genetic susceptibility to metabolic associated fatty liver disease (MAFLD) is complex and poorly characterized. Accurate characterization of the genetic background of hepatic fat content would provide insights into disease etiology and cau…
View article: Crohn’s Disease–Associated Pathogenic Mutation in the Manganese Transporter ZIP8 Shifts the Ileal and Rectal Mucosal Microbiota Implicating Aberrant Bile Acid Metabolism
Crohn’s Disease–Associated Pathogenic Mutation in the Manganese Transporter ZIP8 Shifts the Ileal and Rectal Mucosal Microbiota Implicating Aberrant Bile Acid Metabolism Open
Background A pathogenic mutation in the manganese transporter ZIP8 (A391T; rs13107325) increases the risk of Crohn’s disease. ZIP8 regulates manganese homeostasis and given the shared need for metals between the host and resident microbes,…
View article: P241 Systemic redox status associates with disease activity and clinical phenotypes in Inflammatory Bowel Disease
P241 Systemic redox status associates with disease activity and clinical phenotypes in Inflammatory Bowel Disease Open
Background Oxidative stress is a key pathophysiological mechanism in inflammatory bowel diseases (IBD). Systemic levels of oxidative stress are reflected by reduced levels of free thiols (FT) in circulating proteins, especially those in al…
View article: Temporal colonization and metabolic regulation of the gut microbiome in neonatal oxen at single nucleotide resolution
Temporal colonization and metabolic regulation of the gut microbiome in neonatal oxen at single nucleotide resolution Open
The colonization of microbes in the gut is key to establishing a healthy host-microbiome symbiosis for newborns. We longitudinally profiled the gut microbiome in a model consisting of 36 neonatal oxen from birth up to 2 months postpartum a…
View article: P301 Distinct plasma proteomic biomarkers associate with disease progression in patients with Inflammatory Bowel Diseases
P301 Distinct plasma proteomic biomarkers associate with disease progression in patients with Inflammatory Bowel Diseases Open
Background Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are characterized by complex pathophysiology, phenotypic heterogeneity and disease progression. Patients with IBD show distinct shift…