Shiqun Sun
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View article: Association between low-density lipoprotein cholesterol and coronary plaque progression in non-dialysis chronic kidney disease: a retrospective cohort study
Association between low-density lipoprotein cholesterol and coronary plaque progression in non-dialysis chronic kidney disease: a retrospective cohort study Open
This study aimed to investigate the characteristics of coronary plaque progression in non-dialysis chronic kidney disease (CKD) patients, particularly focusing on the association between low-density lipoprotein cholesterol (LDL-C) levels a…
View article: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study
DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study Open
Background While DNA methylation ( DNAm )‐based algorithms of aging show promise for predicting age‐related diseases, their comparative utility for incident cardiovascular disease ( CVD ) remains underexplored. We aimed to systematically c…
View article: Identification of cross-talk pathways and PANoptosis-related genes in periodontitis and atherosclerosis by bioinformatics analysis and machine learning
Identification of cross-talk pathways and PANoptosis-related genes in periodontitis and atherosclerosis by bioinformatics analysis and machine learning Open
This study reveals the joint mechanism between PD and AS associated with PANoptosis. Analyzing the four core genes and immune cells may provide new therapeutic directions for the pathogenesis of PD combined with AS.
View article: Associations of DNA Methylation Algorithms of Aging With Cardiovascular Disease and Mortality Risk Among US Older Adults
Associations of DNA Methylation Algorithms of Aging With Cardiovascular Disease and Mortality Risk Among US Older Adults Open
Background Several DNA methylation (DNAm) algorithms have recently emerged as robust predictors of aging and adverse health outcomes in older adults, offering valuable insights into cardiovascular disease (CVD) risk stratification. However…
View article: Causal relationship between vitamin D and stress urinary incontinence: Two-sample Mendelian randomization study
Causal relationship between vitamin D and stress urinary incontinence: Two-sample Mendelian randomization study Open
Observational studies have found an association between vitamin D and stress urinary incontinence (SUI); however, this conclusion remains controversial, and the causal relationship is unclear. This study aimed to investigate the causal rel…
View article: Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy
Catalase‐Encapsulated Nanoparticles via Surface Radical Polymerization for Periodontitis Therapy Open
Periodontitis is a prevalent chronic inflammatory disease characterized by oxidative stress and excessive production of reactive oxygen species (ROS), leading to the destruction of periodontal tissues. Despite existing treatments, the mana…
View article: P0142 CD47-SIRPα Contributes to the Microenvironment of Stricturing Crohn's Disease by Mediating the Crosstalk between Macrophages and Stromal cells: “Eat Me” or “Don't Eat Me”
P0142 CD47-SIRPα Contributes to the Microenvironment of Stricturing Crohn's Disease by Mediating the Crosstalk between Macrophages and Stromal cells: “Eat Me” or “Don't Eat Me” Open
Background Intestinal fibrosis is a common complication of Crohn’s disease (CD), but no anti-fibrotic therapy is currently available. Collagen deposition, the pathological characteristics of intestinal fibrosis, is driven by an imbalance b…
View article: Associations of DNA methylation algorithms of aging with cardiovascular disease and mortality risk among US older adults
Associations of DNA methylation algorithms of aging with cardiovascular disease and mortality risk among US older adults Open
Recently, several DNA methylation (DNAm) algorithms have emerged as strong predictors of adverse health outcomes in older adults, offering insights into cardiovascular disease (CVD) risk stratification. Using data from the National Health …
View article: NRF3-mediated mitochondrial superoxide promotes cardiomyocyte apoptosis and impairs cardiac functions by suppressing Pitx2
NRF3-mediated mitochondrial superoxide promotes cardiomyocyte apoptosis and impairs cardiac functions by suppressing Pitx2 Open
Background Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte apoptosis. Nrf3 (Nuclear factor erythroid 2-related factor 3) has an established role in regulating redox signaling and t…
View article: Thrombus aspiration is associated with improved platelet inhibition rate following dual antiplatelet therapy in acute myocardial infarction patients
Thrombus aspiration is associated with improved platelet inhibition rate following dual antiplatelet therapy in acute myocardial infarction patients Open
In conclusion, clinicians should exercise heightened attention towards the bleeding risk among patients undergoing PCI concomitant with Thrombus Aspiration postoperatively.
View article: Liraglutide does not increase heart rate of diabetic patients during acute myocardial infarction
Liraglutide does not increase heart rate of diabetic patients during acute myocardial infarction Open
Background Glucagon‐like peptide 1 receptor agonists have been shown to reduce all‐cause and cardiovascular mortality in patients with Type 2 diabetes mellitus (T2DM). The probable increase in heart rate hinders its early usage in acute my…
View article: TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage
TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage Open
Clinical application of doxorubicin (DOX) is heavily hindered by DOX cardiotoxicity. Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response (DDR), although the mechanism(s) involved remains to …
View article: Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy
Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy Open
Mitochondrial dysfunction is suggested to be a major contributor for the progression of heart failure (HF). Here we examined the role of syntaxin 17 (STX17) in the progression of HF. Cardiac-specific Stx17 knockout manifested cardiac dysfu…
View article: Regulation of osteoclast differentiation and inflammatory signaling by TCF8 in periodontitis
Regulation of osteoclast differentiation and inflammatory signaling by TCF8 in periodontitis Open
Objectives The aim of this study was to explore the potential role of zinc‐finger homeodomain transcription factor (TCF8) in osteoclastogenesis and inflammation during periodontitis. Materials and Methods Rats with periodontitis were induc…
View article: UBE2L3 promotes squamous cell carcinoma progression in the oral cavity and hypopharynx via activating the NF‐κB signaling by increasing IκBα degradation
UBE2L3 promotes squamous cell carcinoma progression in the oral cavity and hypopharynx via activating the NF‐κB signaling by increasing IκBα degradation Open
Oral squamous cell carcinoma (OSCC) and hypopharyngeal squamous cell carcinoma (HSCC) are representative of head and neck squamous cell carcinoma (HNSCC) and the molecular pathogenesis has not been completely clarified. Ubiquitin‐conjugati…
View article: NCAPG, mediated by miR-378a-3p, regulates cell proliferation, cell cycle progression, and apoptosis of oral squamous cell carcinoma through the GSK-3β/β-catenin signaling
NCAPG, mediated by miR-378a-3p, regulates cell proliferation, cell cycle progression, and apoptosis of oral squamous cell carcinoma through the GSK-3β/β-catenin signaling Open
Exploring the molecular mechanism of oral squamous cell carcinoma (OSCC) pathogenesis is of great significance for its improvement and therapy. Non-structural maintenance of chromatin condensin I complex subunit G (NCAPG) is responsible fo…
View article: YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma
YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with poor prognosis and the development of HNSCC is a complex process. Some research have found that YEATS domain-containing 2 (YEATS2) is highly expre…
View article: Deletion of the E3 ubiquitin ligase, Parkin, exacerbates chronic alcohol intake‐induced cardiomyopathy through an Ambra1‐dependent mechanism
Deletion of the E3 ubiquitin ligase, Parkin, exacerbates chronic alcohol intake‐induced cardiomyopathy through an Ambra1‐dependent mechanism Open
Background and Purpose Chronic alcohol consumption contributes to contractile dysfunction and unfavourable geometric changes in myocardium, accompanied by altered autophagy and disturbed mitochondrial homeostasis. The E3 ubiquitin ligase P…
View article: Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy
Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy Open
Doxorubicin is a valuable antineoplastic drug although its clinical use is greatly hindered by its severe cardiotoxicity with dismal target therapy available. Luteolin is a natural product extracted from vegetables and fruits with a wide r…
View article: TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury
TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury Open
Rationale: Ischemic heart disease remains a primary threat to human health, while its precise etiopathogenesis is still unclear. TBC domain family member 15 (TBC1D15) is a RAB7 GTPase-activating protein participating in the regulation of m…
View article: 318 Autophagy-related protein p62 expression is associated with clinicopathologic features and prednisone plus ctx induction treatment efficacy in lupus nephritis
318 Autophagy-related protein p62 expression is associated with clinicopathologic features and prednisone plus ctx induction treatment efficacy in lupus nephritis Open
Background and aims Previous studies found autophagy contributes to the pathogenesis of systemic lupus erythematosus (SLE). Whether autophagy is involved in lupus nephritis (LN) is not elucidated. P62 is a specific substrate that is degrad…
View article: Use of Both Serum Cystatin C and Creatinine as Diagnostic Criteria for Contrast‐Induced Acute Kidney Injury and Its Clinical Implications
Use of Both Serum Cystatin C and Creatinine as Diagnostic Criteria for Contrast‐Induced Acute Kidney Injury and Its Clinical Implications Open
Background Contrast‐induced acute kidney injury ( CI ‐ AKI ) was traditionally defined as an increase in serum creatinine ( sC r) after contrast media exposure. Recently, serum cystatin C ( sCyC ) has been proposed as an alternative to det…
View article: Comparison of Effects of Different Statins on Contrast‐Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings
Comparison of Effects of Different Statins on Contrast‐Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings Open
Statins are a promising new strategy to prevent contrast‐induced acute kidney injury (CI‐AKI). In this study we compared the ameliorative effect of different statins in a rat model of CI‐AKI. Sprague‐Dawley rats were divided into five grou…
View article: Xuezhikang ameliorates contrast media-induced nephropathy in rats via suppression of oxidative stress, inflammatory responses and apoptosis
Xuezhikang ameliorates contrast media-induced nephropathy in rats via suppression of oxidative stress, inflammatory responses and apoptosis Open
XZK's therapeutic effect is similar, or even better than atorvastatin at the same effectual dose in some parts.
View article: Circulating MicroRNA‐188, ‐30a, and ‐30e as Early Biomarkers for Contrast‐Induced Acute Kidney Injury
Circulating MicroRNA‐188, ‐30a, and ‐30e as Early Biomarkers for Contrast‐Induced Acute Kidney Injury Open
Background Contrast‐induced acute kidney injury ( CI ‐ AKI ) is typically defined by an increase in serum creatinine after intravascular administration of contrast medium. Because creatinine is an unreliable indicator of acute changes in k…