Shirley Lidechi
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View article: Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations
Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations Open
Background The InBios SCoV-2 Detect™ IgG ELISA (InBios) and the in-house KWTRP ELISA (KWTRP) have both been used in the estimation of SARS-CoV-2 seroprevalence in Kenya. Whereas the latter has been validated extensively using local samples…
View article: Factors associated with laboratory-confirmed SARS-Cov-2 infection among patients with severe respiratory illness (SRI): Findings from the COVID-19 vaccine effectiveness evaluation in Kenya and Mali, 2022–2023
Factors associated with laboratory-confirmed SARS-Cov-2 infection among patients with severe respiratory illness (SRI): Findings from the COVID-19 vaccine effectiveness evaluation in Kenya and Mali, 2022–2023 Open
Older adults and HIV patients were at increased-risk of SARS-CoV-2 infection consistent with WHO guidelines highlighting the need for targeted prevention and management strategies focused on them.
View article: High prevalence of varicella zoster virus infection among persons with suspect mpox cases during a mpox outbreak in Kenya, 2024
High prevalence of varicella zoster virus infection among persons with suspect mpox cases during a mpox outbreak in Kenya, 2024 Open
During a mpox outbreak in Kenya, 61% of patients suspected of infection tested positive for varicella zoster virus, which causes a rash similar to the mpox rash. Expanding laboratory capacity during the outbreak enhanced disease intelligen…
View article: Profile: The Kenya Multi-Site Serosurveillance (KEMIS) collaboration
Profile: The Kenya Multi-Site Serosurveillance (KEMIS) collaboration Open
The Kenya Multi Site Serosurveillance (KEMIS) collaboration set out to implement an integrated, nationally representative, population-based program of serological surveillance for past infection for a number of important infectious disease…
View article: Early warning and response systems for respiratory disease outbreaks: lessons learnt from cluster-associated cases of acute respiratory illnesses in Gilgil subcounty, Nakuru County, Kenya, 2021
Early warning and response systems for respiratory disease outbreaks: lessons learnt from cluster-associated cases of acute respiratory illnesses in Gilgil subcounty, Nakuru County, Kenya, 2021 Open
Investigating acute respiratory illnesses (ARIs) is difficult due to non-specific symptoms, varied health-seeking behaviors, and resource limitations; yet early detection is critical to global health security. Kenya's Ministry of Health (M…
View article: Impact of HIV Infection and Malaria Parasitemia on Inactivated Influenza Vaccine Immunogenicity in Pregnant Women and Trans-Placental Antibody Transfer
Impact of HIV Infection and Malaria Parasitemia on Inactivated Influenza Vaccine Immunogenicity in Pregnant Women and Trans-Placental Antibody Transfer Open
View article: The cost of care for children hospitalized with respiratory syncytial virus (RSV) associated lower respiratory infection in Kenya
The cost of care for children hospitalized with respiratory syncytial virus (RSV) associated lower respiratory infection in Kenya Open
View article: Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations
Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations Open
Background The InBios SCoV-2 Detect TM IgG ELISA (InBios) and the in-house KWTRP ELISA (KWTRP) have both been used in the estimation of SARS-CoV-2 seroprevalence in Kenya. Whereas the latter has been validated extensively using local samp…
View article: Profile: The Kenya Multi-Site Serosurveillance (KEMIS) collaboration
Profile: The Kenya Multi-Site Serosurveillance (KEMIS) collaboration Open
The Kenya Multi Site Serosurveillance (KEMIS) collaboration set out to implement an integrated, nationally representative, population-based program of serological surveillance for past infection for a number of important infectious disease…
View article: Heterogenous transmission and seroprevalence of SARS-CoV-2 in two demographically diverse populations with low vaccination uptake in Kenya, March and June 2021
Heterogenous transmission and seroprevalence of SARS-CoV-2 in two demographically diverse populations with low vaccination uptake in Kenya, March and June 2021 Open
Background: SARS-CoV-2 has extensively spread in cities and rural communities, and studies are needed to quantify exposure in the population. We report seroprevalence of SARS-CoV-2 in two well-characterized populations in Kenya at two time…
View article: Replication Data for: Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations
Replication Data for: Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations Open
This is a replication dataset for the manuscript titled "Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations." The SARS-CoV-2 serop…
View article: Heterogenous transmission and seroprevalence of SARS-CoV-2 in two demographically diverse populations with low vaccination uptake in Kenya, March and June 2021
Heterogenous transmission and seroprevalence of SARS-CoV-2 in two demographically diverse populations with low vaccination uptake in Kenya, March and June 2021 Open
Background: SARS-CoV-2 has extensively spread in cities and rural communities, and studies are needed to quantify exposure in the population. We report seroprevalence of SARS-CoV-2 in two well-characterized populations in Kenya at two time…
View article: Comparative analysis of SARS-CoV-2 detection methods using stool, blood, and nasopharyngeal swab samples
Comparative analysis of SARS-CoV-2 detection methods using stool, blood, and nasopharyngeal swab samples Open
the choice of an appropriate SARS-CoV-2 diagnostic, screening, and surveillance test should be guided by the specific study needs and a rational approach for optimal results.
View article: High seroprevalence of Immunoglobulin G (IgG) and IgM antibodies to SARS-CoV-2 in asymptomatic and symptomatic individuals amidst vaccination roll-out in western Kenya
High seroprevalence of Immunoglobulin G (IgG) and IgM antibodies to SARS-CoV-2 in asymptomatic and symptomatic individuals amidst vaccination roll-out in western Kenya Open
The population’s antibody response is a key factor in comprehending SARS-CoV-2 epidemiology. This is especially important in African settings where COVID-19 impact, and vaccination rates are relatively low. This study aimed at characterizi…
View article: High seroprevalence of Immunoglobulin G (IgG) and IgM antibodies to SARS-CoV-2 in asymptomatic and symptomatic individuals amidst vaccination roll-out in western Kenya
High seroprevalence of Immunoglobulin G (IgG) and IgM antibodies to SARS-CoV-2 in asymptomatic and symptomatic individuals amidst vaccination roll-out in western Kenya Open
Background The population’s antibody response is a key factor in comprehending SARS-CoV-2 epidemiology. This is especially important in African settings where COVID-19 impact, and vaccination rates are relatively low. This study aimed at c…
View article: The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020
The burden of influenza among Kenyan pregnant and postpartum women and their infants, 2015–2020 Open
Background In tropical Africa, data about influenza‐associated illness burden are needed to assess potential benefits of influenza vaccination among pregnant women. We estimated the incidence of influenza among pregnant women and their inf…
View article: Effect of Time Since Death on Multipathogen Molecular Test Results of Postmortem Specimens Collected Using Minimally Invasive Tissue Sampling Techniques
Effect of Time Since Death on Multipathogen Molecular Test Results of Postmortem Specimens Collected Using Minimally Invasive Tissue Sampling Techniques Open
Background We used postmortem minimally invasive tissue sampling (MITS) to assess the effect of time since death on molecular detection of pathogens among respiratory illness–associated deaths. Methods Samples were collected from 20 deceas…
View article: The Burden of Influenza among Kenyan Pregnant and postpartum Women and their Infants, 2015--2020
The Burden of Influenza among Kenyan Pregnant and postpartum Women and their Infants, 2015--2020 Open
Objective: To describe the burden of influenza among pregnant women and their young infants. Design: Prospective cohort study. Setting: Rural western Kenya. Population: Pregnant women below 31 weeks of gestation and their infants aged 6 mo…
View article: The Burden of Influenza Among Kenyan Pregnant and Postpartum Women and Their Infants, 2015–2020
The Burden of Influenza Among Kenyan Pregnant and Postpartum Women and Their Infants, 2015–2020 Open
View article: The Impact of Maternal Human Immunodeficiency Virus Infection on the Burden of Respiratory Syncytial Virus Among Pregnant Women and Their Infants, Western Kenya
The Impact of Maternal Human Immunodeficiency Virus Infection on the Burden of Respiratory Syncytial Virus Among Pregnant Women and Their Infants, Western Kenya Open
Background Respiratory syncytial virus (RSV) is an important cause of respiratory illness worldwide; however, burden data on mother–infant pairs remain sparse in sub-Saharan Africa, where human immunodeficiency virus (HIV) is prevalent. We…
View article: Detection of pandemic influenza A/H1N1/pdm09 virus among pigs but not in humans in slaughterhouses in Kenya, 2013–2014
Detection of pandemic influenza A/H1N1/pdm09 virus among pigs but not in humans in slaughterhouses in Kenya, 2013–2014 Open
View article: Seroprevalence of influenza A virus in pigs and low risk of acute respiratory illness among pig workers in Kenya
Seroprevalence of influenza A virus in pigs and low risk of acute respiratory illness among pig workers in Kenya Open
View article: Comparison of respiratory pathogen yields from Nasopharyngeal/Oropharyngeal swabs and sputum specimens collected from hospitalized adults in rural Western Kenya
Comparison of respiratory pathogen yields from Nasopharyngeal/Oropharyngeal swabs and sputum specimens collected from hospitalized adults in rural Western Kenya Open
Molecular diagnostic methods are becoming increasingly available for assessment of acute lower respiratory illnesses (ALRI). However, nasopharyngeal/oropharyngeal (NP/OP) swabs may not accurately reflect etiologic agents from the lower res…
View article: A diagnostic and epidemiologic investigation of acute febrile illness (AFI) in Kilombero, Tanzania
A diagnostic and epidemiologic investigation of acute febrile illness (AFI) in Kilombero, Tanzania Open
This study is the first to employ two syndromic TaqMan Array Cards for the simultaneous survey of 57 different organisms to better characterize the type and prevalence of detected agents among febrile patients. Additionally, we provide an …
View article: Evaluation of a TaqMan Array Card for Detection of Central Nervous System Infections
Evaluation of a TaqMan Array Card for Detection of Central Nervous System Infections Open
Infections of the central nervous system (CNS) are often acute, with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that m…