Shiro Aoki
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View article: Indicators associated with outcomes of in-hospital ischemic stroke
Indicators associated with outcomes of in-hospital ischemic stroke Open
The conditions underlying IHIS are diverse, with differences in the time from recognition to assessment and varying rates of reperfusion therapy. The D-dimer level was identified as a factor that is independently associated with poor outco…
View article: Vasculitic Neuropathy With Iron Deficiency-Related Chronic Inflammation Followed by Elevated Serum Vascular Endothelial Growth Factor: A POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome Mimic
Vasculitic Neuropathy With Iron Deficiency-Related Chronic Inflammation Followed by Elevated Serum Vascular Endothelial Growth Factor: A POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome Mimic Open
View article: Zilucoplan for Successful Early Weaning From Mechanical Ventilation and Avoiding Tracheostomy in an 85-Year-Old Woman Experiencing Myasthenic Crisis: A Case Report
Zilucoplan for Successful Early Weaning From Mechanical Ventilation and Avoiding Tracheostomy in an 85-Year-Old Woman Experiencing Myasthenic Crisis: A Case Report Open
View article: Usefulness of Myelin Quantification Using Synthetic Magnetic Resonance Imaging for Predicting Outcomes in Patients With Acute Ischemic Stroke
Usefulness of Myelin Quantification Using Synthetic Magnetic Resonance Imaging for Predicting Outcomes in Patients With Acute Ischemic Stroke Open
BACKGROUND: Synthetic magnetic resonance imaging (MRI) is an innovative MRI technology that enables the acquisition of multiple quantitative values, including T1 and T2 values, proton density, and myelin volume, in a single scan. Although …
View article: A Dark Optic Nerve Illuminates the Aspergillosis Diagnosis
A Dark Optic Nerve Illuminates the Aspergillosis Diagnosis Open
View article: Early initiation of intravenous cyclophosphamide and one‐year outcome in super‐refractory cryptogenic‐new onset refractory status epilepticus
Early initiation of intravenous cyclophosphamide and one‐year outcome in super‐refractory cryptogenic‐new onset refractory status epilepticus Open
To explore the potential efficacy of early initiation of intravenous cyclophosphamide (IVCPA), we reviewed consecutive four cases of super‐refractory cryptogenic‐new onset refractory status epilepticus (C‐NORSE) between 2015 and 2023. We c…
View article: Pembrolizumab-associated Neuronopathy with Improved Lower Limb Somatosensory Evoked Potential After Intravenous Methylprednisolone Treatment
Pembrolizumab-associated Neuronopathy with Improved Lower Limb Somatosensory Evoked Potential After Intravenous Methylprednisolone Treatment Open
Cases of neuronopathy associated with immune checkpoint inhibitors (ICIs) have rarely been reported. We herein report a case of ICI-associated neuronopathy. A 54-year-old man underwent chemotherapy for right maxillary sinus cancer. Two mon…
View article: Clinical characteristics and outcomes of acute ischemic stroke in Hiroshima city during the COVID-19 era from HARP study
Clinical characteristics and outcomes of acute ischemic stroke in Hiroshima city during the COVID-19 era from HARP study Open
View article: Clinical manifestations and outcomes associated with a high 2HELPS2B score in patients with acute impaired consciousness
Clinical manifestations and outcomes associated with a high 2HELPS2B score in patients with acute impaired consciousness Open
View article: A case of Parkinson's disease with exacerbation of parkinsonism due to dural arteriovenous fistula
A case of Parkinson's disease with exacerbation of parkinsonism due to dural arteriovenous fistula Open
確定診断されたパーキンソン病の74歳女性に硬膜動静脈瘻(dural arteriovenous fistula: DAVF)によるパーキンソニズムが合併した症例を初めて報告する.7年間のパーキンソン病罹患歴があり,2カ月の経過で薬剤不応性の歩行障害を主体とするパーキンソニズムおよび意識障害が出現し入院した.MRI,MRA/Vで皮質下白質の浮腫性変化や脳静脈環流異常が疑われ,精査の結果,右横−S状静脈洞部DAVFが判明した.入院第5病日に血管内治療を行い血行動態は改善した.術…
View article: Vagus nerve size determined via ultrasonography is associated with white matter lesions in patients with vascular risk factors
Vagus nerve size determined via ultrasonography is associated with white matter lesions in patients with vascular risk factors Open
Purpose The cross-sectional area (CSA) of the cervical vagus nerve (VN), as assessed through ultrasonography, might be linked to autonomic nervous system dysfunction. Hypertension is the primary factor associated with cerebral white matter…
View article: Oral condition at admission predicts functional outcomes and hospital-acquired pneumonia development among acute ischemic stroke patients
Oral condition at admission predicts functional outcomes and hospital-acquired pneumonia development among acute ischemic stroke patients Open
Introduction Oral care is crucial for the prevention of cardiovascular events and pneumonia. However, few studies have evaluated the associations between multidimensional assessments of oral status or functional outcomes and hospital-acqui…
View article: Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary to Cancer Therapy-related Cardiac Dysfunction
Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary to Cancer Therapy-related Cardiac Dysfunction Open
An 11-year-old boy developed cardioembolic stroke (CES) and cancer therapy-related cardiac dysfunction (CTRCD). He originally developed Ewing sarcoma and was treated with high-dose chemotherapy including doxorubicin. On admission, he had s…
View article: Pembrolizumab-associated neuronopathy with improved lower limb somatosensory evoked potential after intravenous methylprednisolone treatment: A case report
Pembrolizumab-associated neuronopathy with improved lower limb somatosensory evoked potential after intravenous methylprednisolone treatment: A case report Open
Background: Peripheral neuropathy associated with immune checkpoint inhibitor (ICI) has been reported in several cases; however, cases of ICI-associated neuronopathy are rare. Herein, we report a case of ICI-associated neuronopathy with ac…
View article: An Early Neurological Indicator of Immune Effector Cell-Associated Neurotoxicity Syndrome
An Early Neurological Indicator of Immune Effector Cell-Associated Neurotoxicity Syndrome Open
View article: Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging
Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging Open
View article: Emergency medical service response for cases of stroke-suspected seizure: A population-based study
Emergency medical service response for cases of stroke-suspected seizure: A population-based study Open
View article: Liver fibrosis index is associated with functional outcome among acute ischemic stroke patients
Liver fibrosis index is associated with functional outcome among acute ischemic stroke patients Open
View article: On-scene time delays for epileptic seizures in developed community-based integrated care system regions
On-scene time delays for epileptic seizures in developed community-based integrated care system regions Open
View article: Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging
Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging Open
Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This report presents a patient who developed PML due to SLE-associated lymphocytopenia. A 60-year-old woman diagnosed with …
View article: Acute amnesic symptoms due to bilateral fornix column infarction: a Case Report
Acute amnesic symptoms due to bilateral fornix column infarction: a Case Report Open
Introduction: The fornix is a part of the Papez circuit and is associated with memory formation. Pure fornix infarction is a very rare type of stroke that causes symptoms such as transient global amnesia (TGA), but the degree of memory imp…
View article: Density spectrum array and difficult to diagnose seizure activity
Density spectrum array and difficult to diagnose seizure activity Open
We present a case with non-convulsive status (NCSE) in which density spectrum array (DSA) illustrated "three little seizures." The conventional EEG was not useful. However, DSA revealed three seizures lasting for 30-40 seconds with a gradu…
View article: Case report: Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C>T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient
Case report: Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C>T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient Open
Mitochondrial trifunctional protein (MTP) deficiency is an autosomal recessive disorder caused by impaired metabolism of long-chain fatty acids (LCFAs). Childhood and late-onset MTP deficiency is characterized by myopathy/rhabdomyolysis an…
View article: On-scene time delays for epileptic seizures in emergencies during a social pandemic: A population-based study
On-scene time delays for epileptic seizures in emergencies during a social pandemic: A population-based study Open
View article: Encephalopathy after COVID-19 vaccination during treatment with nivolumab: A case report
Encephalopathy after COVID-19 vaccination during treatment with nivolumab: A case report Open
View article: Immediate and 6-month seizure outcomes following first and second SARS-CoV2 mRNA vaccinations: A multicenter study with a nationwide survey
Immediate and 6-month seizure outcomes following first and second SARS-CoV2 mRNA vaccinations: A multicenter study with a nationwide survey Open
View article: ‘Raisin bread sign’ feature of pontine autosomal dominant microangiopathy and leukoencephalopathy
‘Raisin bread sign’ feature of pontine autosomal dominant microangiopathy and leukoencephalopathy Open
Pontine autosomal dominant microangiopathy and leukoencephalopathy is one of hereditary cerebral small vessel diseases caused by pathogenic variants in COL4A1 3′UTR and characterized by multiple small infarctions in the pons. We attempted …
View article: Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching
Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching Open
View article: Association between Carotid Wall Shear Stress-Based Vascular Vector Flow Mapping and Cerebral Small Vessel Disease
Association between Carotid Wall Shear Stress-Based Vascular Vector Flow Mapping and Cerebral Small Vessel Disease Open
EPVS has recently been reported as a marker of early SVD imaging, and executive dysfunction is common in vascular cognitive impairment. These results suggested that decreased carotid WSS based on vascular VFM, which can be measured easily,…
View article: A longitudinal seizure outcome following the COVID-19 pandemic in 2020 and 2021: Transient exacerbation or sustainable mitigation
A longitudinal seizure outcome following the COVID-19 pandemic in 2020 and 2021: Transient exacerbation or sustainable mitigation Open