Shiro Fukuda
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View article: <i>Hox</i> – <i>Meis</i> -relayed topographical genetic switch underlies cardiopharyngeal neural crest diversification, revealed by multimodal analysis
<i>Hox</i> – <i>Meis</i> -relayed topographical genetic switch underlies cardiopharyngeal neural crest diversification, revealed by multimodal analysis Open
Neural crest cells (NCCs) are multipotent migratory cells essential for cardiac development, yet the lineage trajectories and gene regulatory networks (GRNs) underlying their intracardiac differentiation remain unclear. Here, we integrate …
View article: Safety of Anesthesia With Dexmedetomidine for Muscle and Nerve Biopsy – A Review of 100 Cases
Safety of Anesthesia With Dexmedetomidine for Muscle and Nerve Biopsy – A Review of 100 Cases Open
Pain during muscle and nerve biopsies is a distressing complication for patients. Dexmedetomidine, an α2-adrenoreceptor agonist, has analgesic as well as sedative effects and causes less respiratory depression. This study aimed to clarify …
View article: AB019. Detailed analysis of DNA hydroxymethylation observed with the malignant progression of IDH-mutant gliomas
AB019. Detailed analysis of DNA hydroxymethylation observed with the malignant progression of IDH-mutant gliomas Open
This study elucidates the importance of region-specific DNA hydroxymethylation in the MP of IDH-mt astrocytomas, suggesting its potential impact on gene expression relevant to cancer malignancy. Our findings propose a complex interplay bet…
View article: Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S6 contains results from the analysis of DNA methylation in SETD2 mutated and BAP1 inactivated samples.
View article: Table S7 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S7 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S7 contains microbe screening results.
View article: Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Supplementary materials and methods, as well as supplementary figures S1-S7.
View article: Table S1 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S1 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S1 contains cohort description, Master Patient Table and MutSigCV results.
View article: Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S4 includes immune signature and iCluster results.
View article: Table S2 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S2 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S2 contains BAP1 analysis results, as well as detailed lists of YY1 and IRF8 target genes.
View article: Table S5 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S5 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S5 contains detailed miRs and lncRNAs results.
View article: Table S3 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S3 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S3 contains the karyotypes of 16 genome-wide LOH MPM cases from the BWH cohort.
View article: Table S3 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S3 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S3 contains the karyotypes of 16 genome-wide LOH MPM cases from the BWH cohort.
View article: Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S4 includes immune signature and iCluster results.
View article: Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1
View article: Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Supplementary materials and methods, as well as supplementary figures S1-S7.
View article: Table S5 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S5 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S5 contains detailed miRs and lncRNAs results.
View article: Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1
View article: Table S7 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S7 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S7 contains microbe screening results.
View article: Table S2 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S2 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S2 contains BAP1 analysis results, as well as detailed lists of YY1 and IRF8 target genes.
View article: Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S6 contains results from the analysis of DNA methylation in SETD2 mutated and BAP1 inactivated samples.
View article: Table S1 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S1 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S1 contains cohort description, Master Patient Table and MutSigCV results.
View article: Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Table S1 shows Clinical features. Table S2 shows Patient/sample information and NGS statistics. Table S3 shows Methylation status of CpG sites of WNT targets with CTNNB1 mutation. Table S4 shows Chromosomal aberrations.
View article: Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Supplementary Figure legends
View article: Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Figure S1 shows Histological findings of stepwise hepatocarcinogenesis and somatic substitution patterns. Figure S2 shows Activation of WNT targets. Figure S3 shows Homozygous deletion in 4q and 16q. Figure S4 shows Circos plot and transcr…
View article: Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Supplementary Figure legends
View article: Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Figure S1 shows Histological findings of stepwise hepatocarcinogenesis and somatic substitution patterns. Figure S2 shows Activation of WNT targets. Figure S3 shows Homozygous deletion in 4q and 16q. Figure S4 shows Circos plot and transcr…
View article: Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Table S1 shows Clinical features. Table S2 shows Patient/sample information and NGS statistics. Table S3 shows Methylation status of CpG sites of WNT targets with CTNNB1 mutation. Table S4 shows Chromosomal aberrations.
View article: Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Cancer develops through the accumulation of genetic and epigenetic aberrations. To identify sequential molecular alterations that occur during the development of hepatocellular carcinoma (HCC), we compared 52 early and 108 overt HCC sample…
View article: Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Cancer develops through the accumulation of genetic and epigenetic aberrations. To identify sequential molecular alterations that occur during the development of hepatocellular carcinoma (HCC), we compared 52 early and 108 overt HCC sample…
View article: Cardiac neural crest lineage diversity and underlying gene regulatory networks revealed by multimodal analysis
Cardiac neural crest lineage diversity and underlying gene regulatory networks revealed by multimodal analysis Open
Neural crest cells (NCCs), a multipotent stem cell population, contribute to cardiac development as a source of the outflow septum, vascular smooth muscle and semilunar valves. However, genetic programs underlying lineage diversification o…