Shirsendu Ghosh
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View article: Synergy between Membrane Topography and Domains to Control Signaling Protein Localization in Mast Cells Facilitates their Activation
Synergy between Membrane Topography and Domains to Control Signaling Protein Localization in Mast Cells Facilitates their Activation Open
Similar to T cells and B cells, mast cell surfaces are dominated by microvilli, and like these other immune cells we showed with microvillar cartography (MVC) that key signaling proteins for RBL mast cells localize to these topographical f…
View article: Control of protein activity by photoinduced spin polarized charge reorganization
Control of protein activity by photoinduced spin polarized charge reorganization Open
Considerable electric fields are present within living cells, and the role of bioelectricity has been well established at the organismal level. Yet much remains to be learned about electric-field effects on protein function. Here, we use p…
View article: Control of protein activity by photoinduced spin polarized charge reorganization
Control of protein activity by photoinduced spin polarized charge reorganization Open
Considerable electric fields are present within living cells, and the role of bioelectricity has been well established at the organismal level. Yet little is known about electric-field effects on protein function. Here we use phototriggere…
View article: CCR7 signalosomes are preassembled on tips of lymphocyte microvilli in proximity to LFA-1
CCR7 signalosomes are preassembled on tips of lymphocyte microvilli in proximity to LFA-1 Open
View article: Substrates Modulate Charge-Reorganization Allosteric Effects in Protein–Protein Association
Substrates Modulate Charge-Reorganization Allosteric Effects in Protein–Protein Association Open
Protein function may be modulated by an event occurring far away from the functional site, a phenomenon termed allostery. While classically allostery involves conformational changes, we recently observed that charge redistribution within a…
View article: Substrates modulate charge-reorganization allosteric effects in protein-protein association
Substrates modulate charge-reorganization allosteric effects in protein-protein association Open
Protein function may be modulated by an event occurring far away from the functional site, a phenomenon termed allostery. While classically allostery involves conformational changes, we recently observed that charge redistribution within a…
View article: Substrates modulate charge-reorganization allosteric effects in\n protein-protein association
Substrates modulate charge-reorganization allosteric effects in\n protein-protein association Open
Protein function may be modulated by an event occurring far away from the\nfunctional site, a phenomenon termed allostery. While classically allostery\ninvolves conformational changes, we recently observed that charge\nredistribution withi…
View article: Substrates modulate charge-reorganization allosteric effects in protein-protein association
Substrates modulate charge-reorganization allosteric effects in protein-protein association Open
Protein function may be modulated by an event occurring far away from the functional site, a phenomenon termed allostery. While classically allostery involves conformational changes, we recently observed that charge redistribution within a…
View article: Long-Range Charge Reorganization as an Allosteric Control Signal in Proteins
Long-Range Charge Reorganization as an Allosteric Control Signal in Proteins Open
A new mechanism of allostery in proteins, based on charge rather than structure, is reported. We demonstrate that dynamic redistribution of charge within a protein can control its function and affect its interaction with a binding partner.…
View article: Microvillar cartography: a super-resolution single-molecule imaging method to map the positions of membrane proteins with respect to cellular surface topography
Microvillar cartography: a super-resolution single-molecule imaging method to map the positions of membrane proteins with respect to cellular surface topography Open
We introduce Microvillar Cartography (MC), a method to map proteins on cellular surfaces with respect to the membrane topography. The surfaces of many cells are not smooth, but are rather covered with various protrusions such as microvilli…
View article: ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation
ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation Open
View article: ERM-Dependent Assembly of T-Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli Prior to Activation
ERM-Dependent Assembly of T-Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli Prior to Activation Open
Summary T-cell surfaces are covered with microvilli, actin-rich and flexible protrusions. We use super-resolution microscopy to show that ≥90% T-cell receptor (TCR) complex molecules TCRαβ and TCRζ, as well as the co-receptor CD4 and the c…
View article: Preferential targeting of i-motifs and G-quadruplexes by small molecules
Preferential targeting of i-motifs and G-quadruplexes by small molecules Open
Ligand-dependent regulation of gene expression has been delineated by targeting i-motifs and G-quadruplexes.
View article: Cover Picture: Fluorescence Dynamics in the Endoplasmic Reticulum of a Live Cell: Time‐Resolved Confocal Microscopy (ChemPhysChem 18/2016)
Cover Picture: Fluorescence Dynamics in the Endoplasmic Reticulum of a Live Cell: Time‐Resolved Confocal Microscopy (ChemPhysChem 18/2016) Open
The Front Cover picture illustrates the study of fluorescence dynamics in the endoplasmic reticulum of live cancer and non-cancer cells by time-resolved confocal microscopy. More information can be found in the Full Paper by K. Bhattachary…
View article: Fluorescence Dynamics in the Endoplasmic Reticulum of a Live Cell: Time‐Resolved Confocal Microscopy
Fluorescence Dynamics in the Endoplasmic Reticulum of a Live Cell: Time‐Resolved Confocal Microscopy Open
The front cover artwork is provided by the group of Prof. Kankan Bhattacharyya. The image shows calcium ion binding/unbinding in the endoplasmic reticulum (ER) region involved complex structural reorganizations. The consequent fluctuations…
View article: Small molecule regulated dynamic structural changes of human G-quadruplexes
Small molecule regulated dynamic structural changes of human G-quadruplexes Open
A carbazole derivative (BTC) regulates the dynamics of unstructured humanc-MYCandh-TELOsequences by folding them into compact quadruplex structures.