Shiru Chen
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View article: CAPMix: Robust Time Series Anomaly Detection Based on Abnormal Assumptions with Dual-Space Mixup
CAPMix: Robust Time Series Anomaly Detection Based on Abnormal Assumptions with Dual-Space Mixup Open
Time series anomaly detection (TSAD) is a vital yet challenging task, particularly in scenarios where labeled anomalies are scarce and temporal dependencies are complex. Recent anomaly assumption (AA) approaches alleviate the lack of anoma…
View article: Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma
Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma Open
Our study revealed that SCAFs were strongly correlated with cancer stemness in HCC. A novel machine learning model based on senescent CAF-related genes was constructed to accurately predict prognosis in HCC patients. Furthermore, CTHRC1 wa…
View article: Anti-CTGF/PD-1 bispecific antibody Y126S restrains desmoplastic and immunosuppressive microenvironment in pancreatic cancer
Anti-CTGF/PD-1 bispecific antibody Y126S restrains desmoplastic and immunosuppressive microenvironment in pancreatic cancer Open
Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic and immunosuppressive tumor microenvironment (TME), limiting the efficacy of immune checkpoint inhibitors such as anti-programmed cell death 1 (PD-1). Me…
View article: PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is characterized by cancer cells surrounded by affluent stromal components, which may underlie their limited response to various therapeutic interventions, including immunotherapy. Inflammatory cance…
View article: Serum CA19-9 and CEA levels, serum CAT, GSH, oxidised glutathione levels, 8-dihidro-2'-deoksiguanosina and F2-isoprostanes levels in colorectal cancer patients and Lactobacillus: A randomised double-blind controlled trial
Serum CA19-9 and CEA levels, serum CAT, GSH, oxidised glutathione levels, 8-dihidro-2'-deoksiguanosina and F2-isoprostanes levels in colorectal cancer patients and Lactobacillus: A randomised double-blind controlled trial Open
Background: Oxidative stress (OS) plays a crucial role in colorectal cancer (CRC) progression. Lactobacillus has been proposed as a potential modulator of OS. This randomised controlled trial aimed to evaluate the effects of Lactobacillus …
View article: Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer
Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer Open
New-onset diabetes (NOD) is a common condition among patients with pancreatic adenocarcinoma (PAAD) and is related to poor clinical outcomes. The potential impact of NOD on PAAD progression and the tumor microenvironment remains unclear. H…
View article: PHIR: A Platform Solution of Data-Driven Health Monitoring for Industrial Robots
PHIR: A Platform Solution of Data-Driven Health Monitoring for Industrial Robots Open
The large-scale application of industrial robots has created a demand for more intelligent and efficient health monitoring, which is more efficiently met by data-driven methods due to the surge in data and the advancement of computing tech…
View article: Complex Cd–Pb Multigenerational Exposure Improves the Growth and Food Utilization of the Cutworm Spodoptera litura
Complex Cd–Pb Multigenerational Exposure Improves the Growth and Food Utilization of the Cutworm Spodoptera litura Open
Concurrent exposure to cadmium (Cd) and lead (Pb) is prevalent in the environment, but information on the long-term impacts of complex Cd–Pb exposure on herbivorous insects, especially at low doses, is scant. We studied the effects of comp…
View article: The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma
The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma Open
Background Cancer-associated fibroblasts (CAFs), an important component of the tumor microenvironment (TME), play crucial roles in tumor stemness. It has been shown in various cancer studies that stanniocalcin-1 (STC1) is secreted by CAFs,…
View article: The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma
The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma Open
Background Cancer associated fibroblasts (CAFs), an important component of the tumor microenvironment (TME), play crucial roles in tumor stemness. Stanniocalcin-1 (STC1) was found secreted by CAFs in various cancers, but its main source an…
View article: The role of B cells in COVID-19 infection and vaccination
The role of B cells in COVID-19 infection and vaccination Open
B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the …