Shisheng Wang
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View article: Phosphorus speciation, controlling factors, and ecological risk assessment in lagoon sediments: a case study of the Shamei Lagoon, Qionghai, Hainan
Phosphorus speciation, controlling factors, and ecological risk assessment in lagoon sediments: a case study of the Shamei Lagoon, Qionghai, Hainan Open
The Shamei Lagoon in Qionghai, Hainan, is an ecologically significant coastal wetland system that has recently faced increasing ecological risks due to phosphorus (P) pollution. In this study, 22 sediment samples were systematically collec…
View article: Removal of high-concentration fluoride wastewater by calcined hydrated calcium aluminate with a two-step process
Removal of high-concentration fluoride wastewater by calcined hydrated calcium aluminate with a two-step process Open
The hydrated calcium aluminate for fluoride removal of high concentration fluoride-containing wastewater was prepared by thermal activation modification. X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), field emission scanni…
View article: ZQL-4c exerts anti-tumor effects by specifically targeting SCD1 in triple-negative breast cancer both in vitro and in vivo
ZQL-4c exerts anti-tumor effects by specifically targeting SCD1 in triple-negative breast cancer both in vitro and in vivo Open
View article: Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis
Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis Open
These findings suggest that the therapeutic effect of MSCs-exo on NASH may be attributed to the regulation of macrophage M2 polarization through miR-24-3p targeting STING. This provides a scientific basis for future clinical application.
View article: Petrological Characteristics and Controlling Factors of Diagenetic Evolution of Beachrocks in Zhaoshu Island, Xisha Islands
Petrological Characteristics and Controlling Factors of Diagenetic Evolution of Beachrocks in Zhaoshu Island, Xisha Islands Open
View article: Synthesis and evaluation of smart drugs with integrated functions for identifying and treating oxidative microenvironments associated with cellular ferroptosis
Synthesis and evaluation of smart drugs with integrated functions for identifying and treating oxidative microenvironments associated with cellular ferroptosis Open
Ferroptosis is a novel form of cell death driven by oxidative damage, and is implicated in various pathological conditions, including neurodegenerative diseases, retinal damage, and ischemia‐reperfusion injury of organs. Inhibiting ferropt…
View article: Solar irradiance prediction model based on CNN-Bi-LSTM-Attention
Solar irradiance prediction model based on CNN-Bi-LSTM-Attention Open
The instability of solar irradiance can lead to power fluctuations in photovoltaic power generation systems, which can have a negative impact on the stability of the power system network. To address this problem, a new solar irradiance pre…
View article: ICN 2023 TOC
ICN 2023 TOC Open
View article: ZQL-4c exerts antitumor effects by specifically targeting SCD1 in triple-negative breast cancer both in vitro and in vivo
ZQL-4c exerts antitumor effects by specifically targeting SCD1 in triple-negative breast cancer both in vitro and in vivo Open
Breast cancer represents the most prevalent tumor among women and serves as a primary cause of cancer-associated mortality in China. Oleanolic acid, a pentacyclic triterpenoid isolated from various natural plants, has demonstrated a wide r…
View article: Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma
Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma Open
Normal adjacent tissues (NATs) of hepatocellular carcinoma (HCC) differ from healthy liver tissues and their heterogeneity may contain biological information associated with disease occurrence and clinical outcome that has yet to be fully …
View article: Association of serum PCSK9 levels with platelet function in patients with acute coronary syndromes
Association of serum PCSK9 levels with platelet function in patients with acute coronary syndromes Open
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates low-density lipoprotein (LDL) homeostasis and plays a key role in acute coronary syndrome (ACS). The cardioprotective effect of PCSK9 inhibition extends beyond LDL…
View article: Temporal Proteomic and Lipidomic Profiles of Cerulein-Induced Acute Pancreatitis Reveal Novel Insights for Metabolic Alterations in the Disease Pathogenesis
Temporal Proteomic and Lipidomic Profiles of Cerulein-Induced Acute Pancreatitis Reveal Novel Insights for Metabolic Alterations in the Disease Pathogenesis Open
The pathophysiological mechanisms of acute pancreatitis (AP) are complex and have remained a mystery to date, but metabolism is gradually recognized as an important driver of AP onset and development. We used a cerulein-induced AP mouse mo…
View article: Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities
Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities Open
Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cance…
View article: A basic phosphoproteomic-DIA workflow integrating precise quantification of phosphosites in systems biology
A basic phosphoproteomic-DIA workflow integrating precise quantification of phosphosites in systems biology Open
Phosphorylation is one of the most important post-translational modifications (PTMs) of proteins, governing critical protein functions. Most human proteins have been shown to undergo phosphorylation, and phosphoproteomic studies have been …
View article: Integrative Proteomic and Metabolomic Studies Reveal the Crucial Involvement of the Arachidonic Acid-Leukotriene Pathway and Cathepsins in the Progression of PVNS
Integrative Proteomic and Metabolomic Studies Reveal the Crucial Involvement of the Arachidonic Acid-Leukotriene Pathway and Cathepsins in the Progression of PVNS Open
View article: Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application
Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application Open
Human spermatozoa proteomics exposed to some physical, biological or chemical stressors is being explored. However, there is a lack of optimized sample preparation methods to achieve in-depth protein coverage for sperm cells. Meanwhile, it…
View article: Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application
Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application Open
Human spermatozoa proteomics exposed to some physical, biological or chemical stressors is being explored. However, there is a lack of optimized sample preparation methods to achieve in-depth protein coverage for sperm cells. Meanwhile, it…
View article: Proteotype Co-evolution and Diversity in Mammals
Proteotype Co-evolution and Diversity in Mammals Open
Evolutionary profiling has been largely limited to the nucleotide level. Using consistent proteomic methods, we quantified proteomic and phosphoproteomic layers in fibroblasts from 11 common mammalian species, with transcriptomic variabili…
View article: Urine Proteome in Distinguishing Hepatic Steatosis in Patients with Metabolic-Associated Fatty Liver Disease
Urine Proteome in Distinguishing Hepatic Steatosis in Patients with Metabolic-Associated Fatty Liver Disease Open
Background: In patients with metabolic-associated fatty liver disease (MAFLD), hepatic steatosis is the first step of diagnosis, and it is a risk predictor that independently predicts insulin resistance, cardiovascular risk, and mortality.…
View article: Recovery of Flake Graphite from KR Desulfurization Slag
Recovery of Flake Graphite from KR Desulfurization Slag Open
In the desulfurization process of molten iron, the supersaturated carbon dissolved in molten iron precipitates in the form of graphite. In this paper, according to the characteristics of graphite contained in molten iron desulfurization sl…
View article: N‐((1‐(4‐Fluorophenyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl)‐2‐methylene‐3‐oxo‐olean‐12‐en‐28‐amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch‐Akt Signaling Pathway
N‐((1‐(4‐Fluorophenyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl)‐2‐methylene‐3‐oxo‐olean‐12‐en‐28‐amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch‐Akt Signaling Pathway Open
Breast cancer is of the leading causes of cancer‐related deaths and the most frequently diagnosed cancer among females worldwide. Despite advancements in breast cancer therapy, the disease eventually progresses in most patients because of …
View article: Elevated N-Glycosylation Contributes to the Cisplatin Resistance of Non-Small Cell Lung Cancer Cells Revealed by Membrane Proteomic and Glycoproteomic Analysis
Elevated N-Glycosylation Contributes to the Cisplatin Resistance of Non-Small Cell Lung Cancer Cells Revealed by Membrane Proteomic and Glycoproteomic Analysis Open
Chemoresistance is the major restriction on the clinical use of cisplatin. Aberrant changes in protein glycosylation are closely associated with drug resistance. Comprehensive study on the role of protein glycosylation in the development o…
View article: An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression
An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression Open
The “molecular machine” C34 could suppress tumor systemically via unimolecule-mediated sono/immunotherapy.
View article: Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy
Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy Open
View article: [Rapid screening of single guide RNA targeting pig genome and the harvesting of monoclonal cells by microarray seal].
[Rapid screening of single guide RNA targeting pig genome and the harvesting of monoclonal cells by microarray seal]. Open
The emergence of regular short repetitive palindromic sequence clusters (CRISPR) and CRISPR- associated proteins 9 (Cas9) gene editing technology has greatly promoted the wide application of genetically modified pigs. Efficient single guid…
View article: Solidified glomerulosclerosis, identified using single glomerular proteomics, predicts end-stage renal disease in Chinese patients with type 2 diabetes
Solidified glomerulosclerosis, identified using single glomerular proteomics, predicts end-stage renal disease in Chinese patients with type 2 diabetes Open
View article: NLRC4 gene silencing-dependent blockade of NOD-like receptor pathway inhibits inflammation, reduces proliferation and increases apoptosis of dendritic cells in mice with septic shock
NLRC4 gene silencing-dependent blockade of NOD-like receptor pathway inhibits inflammation, reduces proliferation and increases apoptosis of dendritic cells in mice with septic shock Open
Septic shock is one of the most significant health concerns across the world, involving hypo-perfusion and defects in tissue energy. The current study investigates the role of NLR family CARD domain containing protein 4 (NLRC4) in s…
View article: Combination of long-acting TRAIL and tumor cell-targeted photodynamic therapy as a novel strategy to overcome chemotherapeutic multidrug resistance and TRAIL resistance of colorectal cancer
Combination of long-acting TRAIL and tumor cell-targeted photodynamic therapy as a novel strategy to overcome chemotherapeutic multidrug resistance and TRAIL resistance of colorectal cancer Open
Chemotherapeutic multidrug resistance (MDR) is the major hindrance for clinical therapy of colorectal cancer (CRC). Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with selective cytotoxicity might overcome MDR of CRC cells…
View article: Urine Proteome in Patients With Metabolic Associated Fatty Liver Disease
Urine Proteome in Patients With Metabolic Associated Fatty Liver Disease Open
View article: Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins
Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins Open