Jaswinder Singh Maras
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View article: Methionine metabolism shapes immune response against Mycobacterium tuberculosis
Methionine metabolism shapes immune response against Mycobacterium tuberculosis Open
Limited reports have elucidated the role of one-carbon metabolism and its impact on the production of pro-inflammatory cytokines in tuberculosis (TB). In this study, reanalysis of the earlier reported scRNAseq data of alveolar macrophages …
View article: Impaired fungal surveillance with Kennedy pathway activation drives acute liver failure, validated in preclinical models
Impaired fungal surveillance with Kennedy pathway activation drives acute liver failure, validated in preclinical models Open
View article: Microbial Scl1 Activates TGFβR1 receptor kinase signalling to Drive Fibrosis – Inflammation Axis in Alcohol-Associated Liver Disease
Microbial Scl1 Activates TGFβR1 receptor kinase signalling to Drive Fibrosis – Inflammation Axis in Alcohol-Associated Liver Disease Open
Background and Aims Alcohol consumption alters gut microbiota, which can affect metabolism, immune regulation, and signalling pathways and lead to alcohol-associated liver disease (ALD). We investigated how alcohol-associated gut microbiot…
View article: Liver Kinome Profiling Identifies PS1145 as a Potential Therapeutic molecule for amelioration of Systemic Inflammation in Alcohol-related Liver Disease
Liver Kinome Profiling Identifies PS1145 as a Potential Therapeutic molecule for amelioration of Systemic Inflammation in Alcohol-related Liver Disease Open
Background and aims Alcohol-related liver disease (ALD) has high mortality due to systemic inflammation. We analysed liver and monocyte kinome profiles in a chronic ethanol-fed pre-clinical rat model to identify therapeutic targets that co…
View article: Metabolomic Profiling of Ashwagandha ( <i>Withania somnifera</i> ): Linking Bioactive Compounds to Functional Therapeutic Roles
Metabolomic Profiling of Ashwagandha ( <i>Withania somnifera</i> ): Linking Bioactive Compounds to Functional Therapeutic Roles Open
Introduction Withania somnifera (Ashwagandha) is a widely used medicinal plant with established roles in traditional systems of medicine. Known for diverse pharmacological effects, including neuroprotection, hepatoprotection, enhancement o…
View article: Circulating Biomarkers for Therapeutic Response to Immune Checkpoint Inhibitor Therapy in Patients with Advanced Lung Cancer
Circulating Biomarkers for Therapeutic Response to Immune Checkpoint Inhibitor Therapy in Patients with Advanced Lung Cancer Open
Immune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in the treatment of advanced lung cancer (ALC), but not all patients benefit. To identify responders, patient selection, categorization, and the identification of sp…
View article: In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model
In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model Open
Alcohol abstinence modulates protein half-lives through Srebf1-Slc27a5 axis, reducing inflammation, steatosis, and oxidative stress, potentially aiding in alcohol-induced liver damage treatment.
View article: Immune-metabolic shifts in acute liver failure caused by HEV infection during pregnancy and their association with obstetric outcomes
Immune-metabolic shifts in acute liver failure caused by HEV infection during pregnancy and their association with obstetric outcomes Open
Background: Hepatitis-E virus (HEV)-induced liver failure during pregnancy leads to maternal and fetal complications. This study investigates the HEV-associated metabolomic and immunological changes to elucidate the worsening of obstetric…
View article: Albumin Oxidation Signatures Serve as Early Predictors of Adverse Outcomes in Alcoholic Hepatitis
Albumin Oxidation Signatures Serve as Early Predictors of Adverse Outcomes in Alcoholic Hepatitis Open
View article: Metabolomic Profiling of Ashwagandha (Withania Somnifera): Linking Bioactive Compounds to Functional Therapeutic Roles
Metabolomic Profiling of Ashwagandha (Withania Somnifera): Linking Bioactive Compounds to Functional Therapeutic Roles Open
View article: Albuminome in Severe Alcohol Associated Hepatitis is Distinct and Helps Stratify Disease Severity and Early Mortality
Albuminome in Severe Alcohol Associated Hepatitis is Distinct and Helps Stratify Disease Severity and Early Mortality Open
View article: Plasma lipidomics and fungal peptide-based community analysis identifies distinct signatures for early mortality in acute liver failure
Plasma lipidomics and fungal peptide-based community analysis identifies distinct signatures for early mortality in acute liver failure Open
Background/Aims: Acute liver failure (ALF) has high mortality predominantly due to compromised immune system and increased vulnerability to bacterial and fungal infections.Methods: Plasma lipidome and fungal peptide-based community (mycobi…
View article: Bile molecular landscape provides pathological insight and classifies signatures predictive of carcinoma of the gall bladder
Bile molecular landscape provides pathological insight and classifies signatures predictive of carcinoma of the gall bladder Open
View article: Ethanol with thioacetamide murine model of alcoholic liver disease identifies hepatic pathways as targets for the human disease
Ethanol with thioacetamide murine model of alcoholic liver disease identifies hepatic pathways as targets for the human disease Open
Using an ethanol-thioacetamide combination in mice results in a faster establishment of AAH with fibrosis than previously known models. Differential protein expression strongly correlates with pathways found altered in human AAH, thus maki…
View article: Diabetic liver-enriched secretory dipeptidyl peptidase 4 (DPP4) fuels gut inflammation via attenuation of autophagy
Diabetic liver-enriched secretory dipeptidyl peptidase 4 (DPP4) fuels gut inflammation via attenuation of autophagy Open
The recurrent pathological inflammation of the gut is a major concern in diabetic patients. With the failure of anti-inflammatory or diabetic drugs to limit relapse of colon inflammation demands the unearthing of mechanistic details underl…
View article: Circulating bacterial peptides and linked metabolomic signatures are indicative of early mortality in pediatric cirrhosis
Circulating bacterial peptides and linked metabolomic signatures are indicative of early mortality in pediatric cirrhosis Open
Background: Patients with pediatric cirrhosis-sepsis (PC-S) attain early mortality. Plasma bacterial composition, the cognate metabolites, and their contribution to the deterioration of patients with PC-S to early mortality are unknown. We…
View article: A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by<i>Mycobacterium tuberculosis</i>
A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by<i>Mycobacterium tuberculosis</i> Open
Phagosome maturation arrest (PMA) imposed by Mycobacterium tuberculosis ( Mtb ) is a classic tool that helps Mtb evade macrophage anti-bacterial responses. The exclusion of RAB7, a small GTPase, from Mtb -phagosomes underscores PMA. Here w…
View article: Ocimum sanctum Alters the Lipid Landscape of the Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in a Mouse Model
Ocimum sanctum Alters the Lipid Landscape of the Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in a Mouse Model Open
Stroke-like injuries in the brain result in not only cell death at the site of the injury but also other detrimental structural and molecular changes in regions around the stroke. A stroke-induced alteration in the lipid profile interferes…
View article: Analytical Method Development for Evaluation of Pharmacokinetics and Tissue Distribution of Thiourea-Based Antivirals through nLC/MS-MS
Analytical Method Development for Evaluation of Pharmacokinetics and Tissue Distribution of Thiourea-Based Antivirals through nLC/MS-MS Open
Thiourea-based antivirals are organosulfur chemical compounds. Due to their various medicinal uses, including antiviral, antioxidant, and anticancer properties, they are becoming more popular. In this study, pharmacokinetics, Metabolism, b…
View article: Dr.
Dr. Open
Ocimum Sanctum Alters the Lipid Landscape of Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in Mice Model
View article: Dr.
Dr. Open
Ocimum Sanctum Alters the Lipid Landscape of Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in Mice Model
View article: Thiourea Derivatives Rejuvenate Dysfunctional Mitochondria in Chronic Hepatitis B Infection
Thiourea Derivatives Rejuvenate Dysfunctional Mitochondria in Chronic Hepatitis B Infection Open
Chronic hepatitis B (CHB) infection and the Hepatitis B virus X protein (HBx) are major risk factors associated with hepatocellular carcinoma (HCC). In CHB infection, HBx induces mitochondrial dysfunction, exhaustion and impaired function …
View article: Thiourea Derivatives Rejuvenate Mitochondria and Provide Anti-viral Activity Against Chronic Hepatitis B Infection
Thiourea Derivatives Rejuvenate Mitochondria and Provide Anti-viral Activity Against Chronic Hepatitis B Infection Open
Chronic hepatitis B (CHB) infection and the Hepatitis B virus protein X (HBx) are a major risk factor for the development of hepatocellular carcinoma (HCC). In CHB, HBx induces mitochondrial dysfunction, exhaustion and impaired function in…
View article: Metabolic alterations unravel the materno–fetal immune responses with disease severity in pregnant women infected with SARS-CoV-2
Metabolic alterations unravel the materno–fetal immune responses with disease severity in pregnant women infected with SARS-CoV-2 Open
Background Pregnancy being immune compromised state, COVID-19 disease poses high risk of premature delivery and threat to fetus. Plasma metabolome regulates immune cellular responses and we aimed to analyze the plasma secretome, metabolome…
View article: Plasma meta-proteome and metabolome identify novel bacterial peptides and metabolites predictive of poor outcomes in Acute Liver Failure
Plasma meta-proteome and metabolome identify novel bacterial peptides and metabolites predictive of poor outcomes in Acute Liver Failure Open
Background and Aims: Acute liver failure (ALF) has high mortality, probably due to accumulation of microbial and metabolic factors in the circulation. Classification of such factors in plasma (non-invasive) could help in stratification of …
View article: Dr.
Dr. Open
Ocimum Sanctum Alters the Lipid Landscape of Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in Mice Model
View article: SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis
SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis Open
Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here, we show that host sirtuin 2 (SIRT2) inhibition by AGK2 significantly …
View article: Circulating bacterial peptides and linked metabolomic signatures are indicative of early mortality in Paediatric Cirrhosis
Circulating bacterial peptides and linked metabolomic signatures are indicative of early mortality in Paediatric Cirrhosis Open
Introduction: Paediatric Cirrhosis-Sepsis (PC-S) patients attain early mortality. Plasma bacterial composition, the cognate metabolites and their contribution in the deterioration of PC-S patients to early mortality in unknown. We aimed to…
View article: Withaferin A Protects against Primary and Recurrent Tuberculosis by Modulating Mycobacterium-Specific Host Immune Responses
Withaferin A Protects against Primary and Recurrent Tuberculosis by Modulating Mycobacterium-Specific Host Immune Responses Open
Despite being extensive, conventional antituberculosis therapy (ATT) is barely proficient in providing sterile immunity to tuberculosis (TB). Failure to constrain the escalating global TB burden due to the emergence of drug-resistant bacte…
View article: Berberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis
Berberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis Open
Stimulation of naïve T cells during primary infection or vaccination drives the differentiation and expansion of effector and memory T cells that mediate immediate and long-term protection. Despite self-reliant rescue from infection, BCG v…