Explanipedia

Process Parameter Screening Through Fractional Factorial Design for the Synthesis of Gold Nanoparticles Open

Harshilkumar Jani, Ketan M. Ranch, Vijay R. Chidrawar, Popat Mohite, Sudarshan Singh · 2025

Nanoparticles (NPs) of noble metals such as gold have garnered significant attention due to their novel optical and catalytic properties, their theranostic properties, as they are biocompatible, and they attract considerable interest in a …

Palm oil mill waste: A review on ecological improvement goals advancement and prospects Open

Pooja V. Nagime, Vijay R. Chidrawar, Shradhanjali Singh, Sheeba Shafi, Sudarshan Singh · 2025

Articulating the multifaceted potential applications of inulin: A review Open

Popat Mohite, Abhijeet Puri, Shubham Munde, Nitin Ade, Dipak S. Thorat , et al. · 2025

Starch Science Advancement: Isolation Techniques, Modification Strategies, and Multifaceted Applications Open

Abhijeet Puri, Popat Mohite, Aakansha Ramole, Sonali Verma, M. S. Kamble , et al. · 2025

Starch is one of the most abundant biopolymers in nature and is widely utilized across various industries, including food, pharmaceuticals, textiles, and packaging. Its attractiveness stems from its renewability, biodegradability, versatil…

Correction: Biomaterials-based biofilters from sugarcane waste: an eco-friendly way to clean water and manage nutrients Open

Dipak S. Thorat, Sudarshan Singh, Yogesh V. Ushir, Karishma Tiwari, Shekhar kokate , et al. · 2025

Polymeric Nanoparticles for Targeted Lung Cancer Treatment: Review and Perspectives Open

Devesh U. Kapoor, Sonu Gandhi, Sambhavi Swarn, Bhupendra G. Prajapati, Supang Khondee , et al. · 2025

Lung cancer remains a foremost cause of cancer-related impermanence globally, demanding innovative and effective therapeutic strategies. Polymeric nanoparticles (NPs) have turned up as a promising transport system for drugs due to their bi…

Redefining Risk, Biomarkers, and Precision Therapy for Hereditary Ovarian Cancer: A Review Open

Ambika Nand Jha, Vinay Gaikwad, Ashok Kumar Gupta, Taufik Mulla, Dave Drashti , et al. · 2025

The early 1990s marked a pivotal era in oncology with the elucidation of the molecular etiology of hereditary cancers, fundamentally transforming our understanding of genetic susceptibility. Ovarian cancer (OC) remains the most fatal gynec…

Development, Molecular Docking, and Anti-Anemia Potential of Polyherbal Formulation Open

Deepak Bharati, Sakshi Nirhali, Abhijeet Puri, Popat Mohite, Sudarshan Singh · 2025

Anemia remains a widespread public health concern, and the search for interventions demonstrating potent anti-anemic activity is critical for reducing its impact among high-risk populations. Conventional iron therapies are associated with …

Value-added-peanut shell as potential source for biofilters: an eco-friendly way to clean water and manage nutrients Open

Dipak S. Thorat, Yogesh V. Ushir, Sudarshan Singh · 2025

Nowadays water pollution is a significant threat to both human health and the environment. This water contamination is caused by urbanisation, industrialisation, and population increase. Due to this problem, there is a need to develop eco-…

Bioactive Compound-Fortified Nanomedicine in the Modulation of Reactive Oxygen Species and Enhancement of the Wound Healing Process: A Review Open

Popat Mohite, Abhijeet Puri, Shubham Munde, Nitin Ade, Aarati Budar , et al. · 2025

Wound healing is a complex biological process that involves the regulation of reactive oxygen species (ROS), which play a critical role in cellular signaling and tissue repair. While the dual nature of ROS means that maintaining controlled…

Phytochemical Characterization, Bioactivities, and Nanoparticle-Based Topical Gel Formulation Development from Four Mitragyna speciosa Varieties Open

Pimporn Anantaworasakul, Weeraya Preedalikit, Phunsuk Anantaworasakul, Sudarshan Singh, Aekkhaluck Intharuksa , et al. · 2025

Mitragyna speciosa (kratom) is a traditional medicinal plant rich in bioactive alkaloids and phenolics, known for their antioxidant and anti-aging properties. This study aimed to develop nanoparticle-based topical gels from ethanolic extra…

Recent Advances in Synthetic Approaches for 1,3,4-Oxadiazole Derivatives: A Comprehensive Review on Therapeutic Applications Open

Tejashree Khamkar, R.M. Kadam, Sachin S. Mali, Babaso Udugade, Sudarshan Singh · 2025

1,3,4-Oxadiazoles are a vital class of nitrogen-containing five-membered heterocycles that have drawn considerable attention due to their diverse pharmacological properties. These compounds exhibit a broad spectrum of biological activities…

Endoplasmic Reticulum Stress and Liver Cancer: Regulation Through Natural Products Open

Nidhi Sharma, Meenakshi Gupta, Mridul Guleria, Mona Anand, Arprita Malhan , et al. · 2025

Cancer is the prime cause of mortality and morbidity globally that demands a proactive strategy for the cure. Despite the availability of several anticancer management approaches and drugs, the treatment remains unsatisfactory due to assoc…

Enhanced Topical Delivery of Methotrexate via Transferosome-Loaded Microneedle Array Patch: Formulation, Optimization, and In Vitro–In Vivo Assessment Open

Snehal Shinde, Anil Kumar Singh, Vijay R. Chidrawar, Amarjitsing Rajput, Sudarshan Singh · 2025

Background: Conventional approaches in treating psoriasis demonstrate several complications. methotrexate (MTX) has been frequently used for its efficacy in managing moderate to severe psoriasis. However, MTX acts as an antagonist in regul…

Biomaterial-Based Additive Manufactured Composite/Scaffolds for Tissue Engineering and Regenerative Medicine: A Comprehensive Review Open

Jigar Vyas, Nensi Raytthatha, Puja Vyas, Bhupendra G. Prajapati, Pimpon Uttayarat , et al. · 2025

Additive manufacturing (AM), also referred to as three-dimensional printing/printed (3DP), has emerged as a transformative approach in the current design and manufacturing of various biomaterials for the restoration of damaged tissues insi…

Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review Open

Min He, Jun Hu, J. S. Deng, Xueqiang Chen, A. K. Singh , et al. · 2025

The intricacies of skin conditions and the limitation of traditional therapeutic strategies make dermal treatment fairly difficult. Recent advancements in nanotechnology field have demonstrated promise in dealing such problems, specificall…

Modified thiomer-based nanomedicines in management of ocular complications: a review Open

Biswajit Basu, S. Mallick, Suman Dhauria, A. Das, Sudarshan Singh · 2025

Thiomer-based nanomedicines provide a diverse approach to delivering ophthalmic drugs and controlling problems. The review digs into the development, characterization, and use of thiomer and modified thiomer-based nanomedicines. It emphasi…

Biomaterials-based biofilters from sugarcane waste: an eco-friendly way to clean water and manage nutrients Open

Dipak S. Thorat, Sudarshan Singh, Yogesh V. Ushir, Karishma Tiwari, Shekhar kokate , et al. · 2025

Water pollution is a huge problem for both the environment and living creature health, thus there is an urgent need to develop practical and environmentally friendly techniques to manage and clean it up. This review analyses the possibilit…

Stimuli-Responsive Self-Healing Ionic Gels: A Promising Approach for Dermal and Tissue Engineering Applications Open

Deepanjan Datta, Viola Colaco, Sony Priyanka Bandi, Namdev Dhas, Leela Sai Lokesh Janardhanam , et al. · 2025

The rapid increase in the number of stimuli-responsive polymers, also known as smart polymers, has significantly advanced their applications in various fields. These polymers can respond to multiple stimuli, such as temperature, pH, solven…

Cellulose-Based Nanofibers Infused with Biotherapeutics for Enhanced Wound-Healing Applications Open

Deepanjan Datta, Sony Priyanka Bandi, Viola Colaco, Namdev Dhas, Suprio Shantanu Saha , et al. · 2025

Nanofibers fabricated from various materials such as polymers, carbon, and semiconductors have been widely used for wound healing and tissue engineering applications due to their excellent nontoxic, biocompatible, and biodegradable propert…

Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review Open

Popat Mohite, Abhijeet Puri, Shubham Munde, Roshan Dave, Showkhiya Khan , et al. · 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing drug solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechno…

Investigation of a Thermoresponsive In Situ Hydrogel Loaded with Nanotriphala: Implications for Antioxidant, Anti-Inflammatory, and Antimicrobial Therapy in Nasal Disorders Open

Rungsinee Phongpradist, Chuda Chittasupho, Sudarshan Singh, Julalak Chorachoo Ontong, Sarin Tadtong , et al. · 2025

Oxidative stress plays a crucial role in chronic nasal disorders, contributing to inflammation, tissue damage, and impaired mucosal function, highlighting the need for targeted therapies. Recent advancements in nasal drug delivery systems …

Smart healthcare: Artificial intelligences impact on drug development and patient care Open

Sachin Mendhi, Krutika Sawarkar, Amruta Shete, Kuldeep Vinchurkar, Sachin S. Mali , et al. · 2025

The integration of artificial intelligence (AI) into healthcare has catalyzed significant advancements in drug development and patient care, revolutionizing traditional methodologies. This review explores the multifaceted impact of AI on c…

Revisiting the potential of natural antimicrobial peptides against emerging respiratory viral disease: a review Open

Neelakanta Sarvashiva Kiran, Sudarshan Singh, Chandrashekar Yashaswini, Bhupendra G. Prajapati · 2025

This review assesses the antiviral capabilities of antimicrobial peptides (AMPs) against SARS-CoV-2 and other respiratory viruses, focussing on their therapeutic potential. AMPs, derived from natural sources, exhibit promising antiviral pr…

Optimization of Rosa AlbaFlower Extract Loaded Solid Lipid Nanoparticle using Box–Behnken Design for Enhanced Bioavailability Open

Ajay Singh, Shradhanjali Singh, Paras Gupta, Shanti Bhushan Mishra, Amit Singh , et al. · 2025

Indomethacin-incorporated microemulsion-laden contact lenses for improved ocular drug delivery and therapeutic efficacy Open

Kashvi Panchal, Y. Patel, Harshilkumar Jani, Mittal Dalal, Vijay R. Chidrawar , et al. · 2025

Conventional eye drops are associated with several limitations, including rapid drug clearance and low bioavailability, with only about 5% of the administered drug reaching the cornea to demonstrate therapeutic efficacy.

Thermosensitive In Situ Ophthalmic Gel for Effective Local Delivery and Antifungal Activity of Ketoconazole Nanoparticles Open

Chutima Chaiwut, Sarin Tadtong, Puriputt Akachaipaibul, Jutamas Jiaranaikulwanitch, Sudarshan Singh , et al. · 2024

Fungal keratitis is a severe ocular infection caused by pathogenic fungi, leading to potential vision loss if untreated. Current antifungal treatments face limitations such as low solubility, poor corneal penetration, and limited therapeut…

Quercetin Reduced and Stabilized Gold Nanoparticle/Al3+: A Rapid, Sensitive Optical Detection Nanoplatform for Fluoride Ion Open

Titilope John Jayeoye, Roselina Panghiyangani, Sudarshan Singh, Nongnuj Muangsin · 2024

In this contribution, facile synthesis of gold nanoparticles (AuNPs) at ambient conditions is reported based on the use of the polyphenolic compound quercetin (QT) as the reducing and stabilizing agent at room temperature (RT). Under alkal…

Biocompatible Coating of Medical Devices for Protection Against Biofilms Open

Popat Mohite, Shubham Munde, Md. Jamir Uddin, Anil Pawar, Sudarshan Singh · 2024

Biofilm formation on surgical device surfaces is a major health issue that leads to higher rates of illness and death and significantly increases healthcare management costs. Conventional antimicrobial treatments do not work well on biofil…

Hydrogel-Forming Microneedles in the Management of Dermal Disorders Through a Non-Invasive Process: A Review Open

Popat Mohite, Abhijeet Puri, Shubham Munde, Nitin Ade, Ashwini Kumar , et al. · 2024

Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (H…

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