Shiva Irani
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View article: The Role of LINC02381 in Modulating Cisplatin Resistance in Ovarian Cancer: A Bioinformatics Approach
The Role of LINC02381 in Modulating Cisplatin Resistance in Ovarian Cancer: A Bioinformatics Approach Open
Cisplatin resistance presents a significant challenge in cancer therapy, emphasizing the necessity for identifying new regulatory elements that influence drug response. Recent research has revealed the importance of long noncoding RNAs (ln…
View article: Varicocele grade does not correlate with the severity of sperm DNA fragmentation levels nor with the amount of improvement in DNA fragmentation following varicocele repair
Varicocele grade does not correlate with the severity of sperm DNA fragmentation levels nor with the amount of improvement in DNA fragmentation following varicocele repair Open
When counseling infertile men undergoing varicocele repair for elevated SDF, the grade of varicocele may not impact the amount of improvement expected in SDF following repair, suggesting that varicocele patients may be counseled similarly …
View article: Optimization of In-Situ Exosome Enrichment Methodology On-a-Chip to Mimic Tumor Microenvironment Induces Cancer Stemness in Glioblastoma Tumor Model
Optimization of In-Situ Exosome Enrichment Methodology On-a-Chip to Mimic Tumor Microenvironment Induces Cancer Stemness in Glioblastoma Tumor Model Open
Understanding cancer etiology requires replicating the tumor microenvironment (TME), which significantly differs from standard in vitro cultures due to nutrient limitations, acidic pH, and oxidative stress. To address this, a microfluidic …
View article: Investigating the effect of micromolecules and growth factors on the proliferation of pancreatic beta cells derived from the proliferation of human induced pluripotent cells
Investigating the effect of micromolecules and growth factors on the proliferation of pancreatic beta cells derived from the proliferation of human induced pluripotent cells Open
View article: Carboxymethyl Chitosan and Chitosan as a Bioactive Delivery System: A Review
Carboxymethyl Chitosan and Chitosan as a Bioactive Delivery System: A Review Open
The functionality and mechanism of bioactive agents (BA) in treating various diseases have been studied as a progressive route. Designing an effective delivery system for transferring these molecules and components is a major challenge. Fo…
View article: Modulation of satiety hormones by Bacteroides thetaiotaomicron, Bacteroides fragilis and their derivatives
Modulation of satiety hormones by Bacteroides thetaiotaomicron, Bacteroides fragilis and their derivatives Open
Obesity is a complex disorder influenced by various factors, including gut microbiota, which play a crucial role in metabolic regulation. This study is aimed to investigate the effects of Bacteroides thetaiotaomicron and Bacteroides fragil…
View article: Doxorubicin loaded exosomes inhibit cancer-associated fibroblasts growth: in vitro and in vivo study
Doxorubicin loaded exosomes inhibit cancer-associated fibroblasts growth: in vitro and in vivo study Open
View article: Association study of TYMS gene expression with TYMS and ENOSF1 genetic variants in neoadjuvant chemotherapy response of gastric cancer
Association study of TYMS gene expression with TYMS and ENOSF1 genetic variants in neoadjuvant chemotherapy response of gastric cancer Open
Background: The present research was designed to study the associations between genetic variants of TYMS and ENOSF1 genes with TYMS and ENOSF1 gene expression in neoadjuvant chemotherapy response among patients with gastric cancer. Methods…
View article: Bioinformatics-driven Identification of lncRNA LINC02381 in Mediating Cisplatin Resistance via IL-12 Induced Wnt/TCF7 Signaling in Ovarian Cancer
Bioinformatics-driven Identification of lncRNA LINC02381 in Mediating Cisplatin Resistance via IL-12 Induced Wnt/TCF7 Signaling in Ovarian Cancer Open
Cisplatin resistance presents a considerable hurdle in the treatment of ovarian cancer, significantly impacting patient outcomes and limiting the effectiveness of chemotherapy. This study employs advanced bioinformatics techniques-includin…
View article: Exploring the inhibitory potential of xanthohumol on MEK1/2: a molecular docking and dynamics simulation investigation
Exploring the inhibitory potential of xanthohumol on MEK1/2: a molecular docking and dynamics simulation investigation Open
Background and purpose: Xanthohumol (Xn), a small molecule found in Humulus lupulus , has shown promise as an anti-cancer compound. This in silico study was performed to understand the mechanism of action of Xn as a natural compound on MEK…
View article: WS6 and 5-iodotubercidin small molecules and growth factors; TGF, HGF, and EGF synergistically enhance proliferation of β-like human induced pluripotent stem cells (iPSCs)
WS6 and 5-iodotubercidin small molecules and growth factors; TGF, HGF, and EGF synergistically enhance proliferation of β-like human induced pluripotent stem cells (iPSCs) Open
Objectives It has been shown that growth factors and small molecules play an essential role in the proliferation of β cells and insulin production. In this study, we investigated the effects of small molecules (WS6 and 5-iodotubercidin) an…
View article: The NRF2-KEAP1 pathway and epigenetic control in colorectal cancer: A promising prognostic and predictive biomarker
The NRF2-KEAP1 pathway and epigenetic control in colorectal cancer: A promising prognostic and predictive biomarker Open
In colorectal cancer (CRC), important genes in the NRF2/KEAP1 pathway may undergo methylation, yet the exact genes that control this pathway in CRC are not entirely understood. Targeting the NRF2/KEAP1 pathway could be a valuable therapeut…
View article: Bioinformatics Study and Experimental Evaluation of miR-182, and miR-34 Expression Profiles in Tuberculosis and Lung Cancer
Bioinformatics Study and Experimental Evaluation of miR-182, and miR-34 Expression Profiles in Tuberculosis and Lung Cancer Open
Background: Lung cancer is one of the most dangerous cancers and tuberculosis is one of the deadliest infectious diseases in the world. Many studies have confirmed the connection between lung cancer and tuberculosis, and also the microRNAs…
View article: Elucidating the Role of a Shared lncRNA-miRNA-mRNA Network in Exacerbating Parkinson’s Disease Symptoms in the Context of COVID-19 Infection
Elucidating the Role of a Shared lncRNA-miRNA-mRNA Network in Exacerbating Parkinson’s Disease Symptoms in the Context of COVID-19 Infection Open
Background and objectivesParkinson's disease (PD) is a common neurodegenerative disorder with unclear molecular mechanisms. Noncoding RNAs, such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), have been identified as critical regu…
View article: Natural based hydrogels promote chondrogenic differentiation of human mesenchymal stem cells
Natural based hydrogels promote chondrogenic differentiation of human mesenchymal stem cells Open
Background: The cartilage tissue lacks blood vessels, which is composed of chondrocytes and ECM. Due to this vessel-less structure, it is difficult to repair cartilage tissue damages. One of the new methods to repair cartilage damage is to…
View article: Evaluation of Immunohistochemical Expression of Survivin and its Correlation with qRT-PCR Results as a Useful Diagnostic Marker in Gastric Cancer
Evaluation of Immunohistochemical Expression of Survivin and its Correlation with qRT-PCR Results as a Useful Diagnostic Marker in Gastric Cancer Open
Background: Today, survivin is known as one of the most specific cancer proteins; provide unique and practical study opportunities. Clinical value of survivin in gastric cancer (GC) is not yet appointed. To establish the expression level o…
View article: Whole Exome Sequencing of Non-Syndromic Hearing Loss Patients
Whole Exome Sequencing of Non-Syndromic Hearing Loss Patients Open
Background: Hearing loss is the second most common disease after mental retardation in Iran. Autosomal recessive non-syndromic hearing loss (ARNSHL) is an extreme and highly heterogeneous disease, for which more than 70 genes have been ide…
View article: Identification of novel potential drugs and miRNAs biomarkers in lung cancer based on gene co-expression network analysis
Identification of novel potential drugs and miRNAs biomarkers in lung cancer based on gene co-expression network analysis Open
Non–small cell lung cancer (NSCLC) is an important cause of cancer-associated deaths worldwide. Therefore, the exact molecular mechanisms of NSCLC are unidentified. The present investigation aims to identify the miRNAs with predictive valu…
View article: Differential Expression of miR-21-5p, miR-20a-5p, TGF-β1, and TGF-β Receptor 2 in Skin, Serum, and Lung Samples Exposed to Sulfur Mustard
Differential Expression of miR-21-5p, miR-20a-5p, TGF-β1, and TGF-β Receptor 2 in Skin, Serum, and Lung Samples Exposed to Sulfur Mustard Open
Sulfur mustard (SM) or mustard gas is a blister chemical agent that causes pulmonary damage by triggering inflammation and oxidative injury. Alterations in microRNA (miR) transcript levels are found in pulmonary diseases and even inflammat…
View article: Xanthohumol hinders invasion and cell cycle progression in cancer cells through targeting MMP2, MMP9, FAK and P53 genes in three-dimensional breast and lung cancer cells culture
Xanthohumol hinders invasion and cell cycle progression in cancer cells through targeting MMP2, MMP9, FAK and P53 genes in three-dimensional breast and lung cancer cells culture Open
View article: Accelerated reconstruction of rat calvaria bone defect using 3D-printed scaffolds coated with hydroxyapatite/bioglass
Accelerated reconstruction of rat calvaria bone defect using 3D-printed scaffolds coated with hydroxyapatite/bioglass Open
Self-healing and autologous bone graft of calvaraial defects can be challenging. Therefore, the fabrication of scaffolds for its rapid and effective repair is a promising field of research. This paper provided a comparative study on the ab…
View article: Design and evaluation of a skin-on-a-chip pumpless microfluidic device
Design and evaluation of a skin-on-a-chip pumpless microfluidic device Open
View article: Clinical importance of TYMS and ENOSF1 genetic variants and mRNA expression levels in response to chemotherapy in Iranian gastric cancer patients
Clinical importance of TYMS and ENOSF1 genetic variants and mRNA expression levels in response to chemotherapy in Iranian gastric cancer patients Open
Background Genetic variants are powerful tools for predicting the effectiveness of chemotherapy drugs. Thymidylate synthase (TS) is a crucial enzyme in gastric cancer patients given neoadjuvant chemotherapy based on 5-Fluorouracil (5-FU). …
View article: Carboxymethyl Chitosan-Functionalized Polyaniline/Polyacrylonitrile Nano-Fibers for Neural Differentiation of Mesenchymal Stem Cells
Carboxymethyl Chitosan-Functionalized Polyaniline/Polyacrylonitrile Nano-Fibers for Neural Differentiation of Mesenchymal Stem Cells Open
View article: Depletion of CNOT4 modulates the DNA damage responses following ionizing radiation (IR)
Depletion of CNOT4 modulates the DNA damage responses following ionizing radiation (IR) Open
Background: The Ccr4–Not complex (CNOT complex in mammals) is a unique and highly conserved complex with numerous cellular functions. Until now, there has been relatively little known about the importance of the CNOT complex subunits in th…
View article: Significance of microRNA-targeted ErbB signaling pathway genes in cardiomyocyte differentiation
Significance of microRNA-targeted ErbB signaling pathway genes in cardiomyocyte differentiation Open
We determined miRNAs and their target genes in the ErbB signaling pathway in cardiomyocyte development and consequently heart pathophysiology progression.
View article: A metabolism targeting three-pronged attack significantly attenuates breast cancer stem cell related markers toward therapeutic application
A metabolism targeting three-pronged attack significantly attenuates breast cancer stem cell related markers toward therapeutic application Open
Tumor metabolism has provided researchers with a promising window to cancer therapy. The metabolic pathways adopted by cancer cells are different from those of normal cells. Thus, metabolism can be considered a linchpin in targeted cancer …
View article: Investigating the effect of B. thetaiotaomicron and its derivatives on the expression of tlr2 and tlr4 genes in STC-1 cell line
Investigating the effect of B. thetaiotaomicron and its derivatives on the expression of tlr2 and tlr4 genes in STC-1 cell line Open
Investigating the effect of B. thetaiotaomicron and its derivatives on the expression of tlr2 and tlr4 genes in STC-1 cell line
View article: Colchicine of <i>Colchicum autumnale</i>, A Traditional Anti-Inflammatory Medicine, Induces Apoptosis by Activation of Apoptotic Genes and Proteins Expression in Human Breast (MCF-7) and Mouse Breast (4T1) Cell Lines.
Colchicine of <i>Colchicum autumnale</i>, A Traditional Anti-Inflammatory Medicine, Induces Apoptosis by Activation of Apoptotic Genes and Proteins Expression in Human Breast (MCF-7) and Mouse Breast (4T1) Cell Lines. Open
We showed that isolated colchicine from Colchicum autumnale and pure standard colchicines modulate the expression levels of several genes and therefore exerting their anticancer effects on both human (MCF-7) and mouse (4T1) breast c…
View article: Relationship between demographic and pathological characteristics on the 5-year survival rate of gastric cancer patients in Tehran province
Relationship between demographic and pathological characteristics on the 5-year survival rate of gastric cancer patients in Tehran province Open
Background: Gastric cancer (GC) is one of the most common malignancies and is considered as one of the leading causes of cancer deaths worldwide. Despite considerable progress in the disease's control and treatment, the patients' survival …